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ProQR Announces Preclinical Proof of Concept Data for AX-0810 Axiomer™ RNA Editing Program Targeting NTCP for Cholestatic Diseases

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水曜日, 5月 8, 2024

LEIDEN, Netherlands & CAMBRIDGE, Mass., May 08, 2024 (GLOBE NEWSWIRE) -- ProQR Therapeutics NV (Nasdaq: PRQR) (ProQR), a company dedicated to changing lives through transformative RNA therapies, today announced new preclinical data for its proprietary Axiomer™ RNA editing technology platform, including the first preclinical proof of concept data for its AX-0810 pipeline program for cholestatic diseases targeting NTCP.

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LEIDEN, Netherlands & CAMBRIDGE, Mass., May 08, 2024 (GLOBE NEWSWIRE) -- ProQR Therapeutics NV (Nasdaq: PRQR) (ProQR), a company dedicated to changing lives through transformative RNA therapies, today announced new preclinical data for its proprietary Axiomer™ RNA editing technology platform, including the first preclinical proof of concept data for its AX-0810 pipeline program for cholestatic diseases targeting NTCP.
“In our AX-0810 program targeting NTCP for cholestatic diseases, we have demonstrated preclinical proof of concept showing that Axiomer RNA editing oligonucleotides can have a meaningful effect on levels of serum biomarker bile acid.
ProQR is developing its AX-0810 program targeting NTCP for Cholestatic Diseases and plans to advance the program to the clinic in late 2024/early 2025.
AX-1412 preclinical proof of concept data and translational data to be reported in H2 2024, with program to advance to the clinic in late 2024/early 2025.

Meta-Analysis of Data from Trials of Machine Perfusion Technologies in Liver Transplantation Demonstrates Clinical Advantages of Hypothermic Oxygenated Machine Perfusion (HOPE), according to Bridge to Life Ltd.

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水曜日, 5月 1, 2024

CHICAGO, May 1, 2024 /PRNewswire/ -- Hypothermic oxygenated machine perfusion (HOPE) of livers awaiting transplantation provides significantly greater outcomes than normothermic machine perfusion (NMP) and ice-box static cold storage (SCS), according to a Cochrane review and meta-analysis of seven clinical trials. The analysis, Machine perfusion in liver transplantation; Cochrane review and meta-analysis, by Samuel James Tingle, MD, et al, Newcastle University, Translational and Clinical Research Institute, Newcastle, United Kingdom; Freeman Hospital, Institute of Transplantation, Newcastle, United Kingdom; Newcastle University, NIHR Blood and Transplant Research Unit, Newcastle, United Kingdom Newcastle University, Translational and Clinical Research Institute, Newcastle, United Kingdom, was shown today in a late-breaker session during The 2024 International Congress of the International Liver Transplantation Society (ILTS) in Houston, Texas.

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CHICAGO, May 1, 2024 /PRNewswire/ -- Hypothermic oxygenated machine perfusion (HOPE) of livers awaiting transplantation provides significantly greater outcomes than normothermic machine perfusion (NMP) and ice-box static cold storage (SCS), according to a Cochrane review and meta-analysis of seven clinical trials.
The analysis included seven randomized trials (1024 transplant recipients from 1301 randomized/included livers); four compared end-ischemic hypothermic oxygenated perfusion (HOPE) with SCS, and three compared normothermic machine perfusion (NMP) with SCS.
Machine perfusion (MP) is a novel method for organ graft preservation before transplantation.
In hypothermic oxygenated perfusion (HOPE), donor livers are perfused through the portal vein with a cold (4 °C), acellular, oxygenated fluid at low vascular pressures.

Two Independent Studies Representing Largest Real-World Experience with Hypothermic Oxygenated Machine Perfusion (HOPE) Reinforce Significant Benefits in Liver Preservation Before Transplantation, according to Bridge to Life Ltd.

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木曜日, 4月 18, 2024

CHICAGO, April 18, 2024 /PRNewswire/ -- Two major presentations collectively representing the largest real-world data experience with HOPE are being presented during the European Liver and Intestine Transplant Association (ELITA) Summit meeting in Madrid, Spain.

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The study, 100 Hypothermic Oxygenated Perfusion liver transplants in a Portuguese centre, was conducted by Júlio Constantino, MD et al.
In the study, conducted between August 2020 and July 2023, HOPE was used effectively in 100 liver transplants.
Data were used from the donor, graft and receptor, as well as data from the intraoperative and postoperative period.
Study investigators also analyzed the development of non-anastomotic biliary stricture (NAS), after excluding arterial complication patients and biliary cast syndrome.

Marine Corps Exchange Embarks on a Global ERP and Inventory Management Transformation with Jesta I.S. and the Cloud

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水曜日, 3月 13, 2024

is thrilled to announce that Marine Corps Community Services (MCCS) has selected Jesta I.S.’s foundational Merchandising ERP for the digital transformation of its Marine Corps Exchange (MCX) stores, totalling more than 160 worldwide.

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is thrilled to announce that Marine Corps Community Services (MCCS) has selected Jesta I.S.’s foundational Merchandising ERP for the digital transformation of its Marine Corps Exchange (MCX) stores, totalling more than 160 worldwide.
The modern architecture of Jesta’s Merchandising ERP will also help MCX realize resilient cloud operations and facilitate the adaptability of future technology enhancements.
Currently headquartered in Quantico, VA, the Marine Corps Exchange was founded in 1897 with the opening of the first store at the Marine Barracks in Boston, MA.
“With Jesta’s Merchandising ERP, the foundation of Jesta’s Vision Retail Management Suite, the Marine Corps Exchange has obtained robust capabilities to unify enterprise data, which ensures data integrity.

JPMorgan Chase Earns 20 Greenwich Excellence and Share Leader Awards for US Small Business and Middle Market Banking

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水曜日, 2月 21, 2024

JPMorgan Chase announced today it has received top honors in the prestigious 2023 Greenwich Excellence Awards, including two Greenwich Share Leader distinctions for achieving #1 market share for U.S. Small Business and #1 market share for U.S. Middle Market Banking.1 Overall, the firm earned a combined 20 awards for its best-in-class customer experience provided to small and middle market businesses.

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JPMorgan Chase announced today it has received top honors in the prestigious 2023 Greenwich Excellence Awards, including two Greenwich Share Leader distinctions for achieving #1 market share for U.S. Small Business and #1 market share for U.S. Middle Market Banking.1 Overall, the firm earned a combined 20 awards for its best-in-class customer experience provided to small and middle market businesses.
In the same cash management category, small business clients ranked the bank highly for its overall digital experience, and middle market banking clients expressed great satisfaction for the bank’s cash management overall, resulting in national and regional recognitions.
Both small and middle market banking clients expressed that they would be likely to recommend JPMorgan Chase.
“Chase for Business serves more than 6 million small business clients across the country.

BofA the Preeminent Leader in Greenwich Digital Transformation Benchmarking Study

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火曜日, 1月 30, 2024

CHARLOTTE, N.C., Jan. 30, 2024 /PRNewswire/ -- Bank of America has received top scores in the annual Coalition Greenwich Digital Transformation Benchmarking Study in recognition of ongoing enhancement of its CashPro® platform. CashPro is the company's digital banking platform accessed by more than 40,000 corporate and commercial clients around the world to manage their treasury, trade and credit operations and perform self-service requests. Highlights from this year's study include:

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Innovations Within the CashPro® Platform Lead to Top Scores Within Digital Channels, Payments & Treasury Management Categories
CHARLOTTE, N.C., Jan. 30, 2024 /PRNewswire/ -- Bank of America has received top scores in the annual Coalition Greenwich Digital Transformation Benchmarking Study in recognition of ongoing enhancement of its CashPro® platform.
1 score in this annual study for its leadership in Digital Channels, for the second consecutive year.
Within the award's U.S. Large Corporate Banking category, Bank of America was recognized for excellence in Overall Digital Experience.
Coalition Greenwich is a leading provider of strategic benchmarking, analytics and data intelligence to the financial services and investment industries.

Enterprise Portal Market Sees Major Growth with Demand for Data-Driven Decision-Making and Seamless Collaboration

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金曜日, 1月 5, 2024

Content management, ECM, Research, Prevalence, Knowledge, Organization, Traction, Machine learning, Portal vein, Enterprise content management, Data management, Intelligence, Communication, Sales

The digital landscape is witnessing a formidable shift as organizations globally turn to Enterprise Portals for streamlined operations and enhanced collaborative efficiency.

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The digital landscape is witnessing a formidable shift as organizations globally turn to Enterprise Portals for streamlined operations and enhanced collaborative efficiency.
A comprehensive analysis has been added to a renowned market research repository, offering in-depth insights into the Global Enterprise Portal Market's size, shares, trends, opportunities, and forecast between 2018 and 2028.
Adoption of enterprise portal solutions is on the rise, spearheaded by the necessity for advanced data management, efficient remote work environments, and tools for data-centric decision-making.
The fresh addition to the research repository promises a wealth of knowledge for businesses and stakeholders looking to understand the evolving Enterprise Portal Market.

Ruppert Properties Unveils Newly Redesigned Company Website

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火曜日, 10月 31, 2023

Digital, Family, Perpetual Real Estate Services, Inc. v. Michaelson Properties, Inc., Leasehold estate, Senior, News, SEO, Portal vein, Property management, Online shopping, Retail, Wellspring

FREDERICK, Md., Oct. 31, 2023 /PRNewswire-PRWeb/ -- Ruppert Properties, a leader in the real estate development and management industry, is delighted to announce the launch of its newly redesigned website. The comprehensive redesign aims to offer visitors a more intuitive online experience that utilizes modern design and interactive resources for clients, partners, and stakeholders alike.

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FREDERICK, Md., Oct. 31, 2023 /PRNewswire-PRWeb/ -- Ruppert Properties, a leader in the real estate development and management industry, is delighted to announce the launch of its newly redesigned website.
- Kate Layman, VP, Ruppert Properties
"Our website is often our first opportunity to leave an impression and we wanted this site to place the same importance on quality and service that we strive for in every other aspect of our operation", said Kate Layman, Vice President of Ruppert Properties.
Key elements of the redesigned website include:
Modern and Engaging Design – Rooted in Ruppert's recognizable brand, the design and layout has been optimized for easy navigation and accessibility across various devices.
Ruppert Properties is a family and employee-owned company that invests, owns and manages flex, industrial and office properties throughout the Baltimore/Washington metropolitan region.

Sernova Announces Positive Ongoing Interim Phase 1/2 Clinical Data for the Cell Pouch System™ for Type 1 Diabetes Trial at the 2023 IPITA, IXA, and CTRMS Joint Congress

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金曜日, 10月 27, 2023

Transplant, Cohort study, Patient, Portal vein, Glycated hemoglobin, Dentistry, Pharmaceutical industry

Enrollment in Cohort A, which utilizes the 8-channel Cell Pouch, is complete with post-transplant data available for periods of follow-up ranging from 6 months to 3.5 years.

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Enrollment in Cohort A, which utilizes the 8-channel Cell Pouch, is complete with post-transplant data available for periods of follow-up ranging from 6 months to 3.5 years.
In Cohort B, 6 of the planned 7 patients have been implanted with the higher capacity 10-channel Cell Pouch, without complications.
Among the 6 patients that have been implanted, 5 have completed at least one of the two protocol-defined islet transplants to Cell Pouch.
“Having recently advanced the trial into Cohort B, using our higher capacity 10-channel Cell Pouch, we are already seeing positive signals for both safety and efficacy.

New Acronis CyberApp Standard Accelerates Ecosystem Growth and Partner Success

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木曜日, 10月 12, 2023

Cloud, Member of the Scottish Parliament, GMT, Corporation, Automation, Risk, Software as a service, Partnership, MDF, Research, Marketing, Acronis, IDC, Portal vein, LastPass, Learning, Partner, Online shopping, PAX8

SCHAFFHAUSEN, Switzerland, Oct. 12, 2023 (GLOBE NEWSWIRE) -- Acronis, the global leader in cyber protection, today announced the Acronis CyberApp Standard a groundbreaking integration technology.

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SCHAFFHAUSEN, Switzerland, Oct. 12, 2023 (GLOBE NEWSWIRE) -- Acronis, the global leader in cyber protection, today announced the Acronis CyberApp Standard a groundbreaking integration technology.
Acronis CyberApp Standard is the only framework that allows vendors to deeply integrate into the Acronis platform with natively incorporated vendor workloads, alerts, widgets, and reports.
Acronis CyberApp Standard offers vendors a unique, no-touch digital experience and complete application lifecycle management, unlike other platforms.
"We are excited to make the CyberApp Standard available to all vendors and open up the Acronis partner ecosystem with over 20,000 service providers and millions of business customers.