Wistar Institute

Wistar Research Identifies Mechanisms for Selective Multiple Sclerosis Treatment Strategy

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火曜日, 5月 28, 2024
Wistar, EBV, PML, Bangladesh Technical Education Board, Phenotype, Nature Microbiology, Nervous system, Patient, Data collection, Wistar Institute, TAF, Sclerosis, Immune system, Travel, FOXP1, Disease, DSM-IV codes, Multiple sclerosis, Epstein–Barr virus infection, SLCL, Liebermann, Neuron, Collaborative writing, Gene, Immortalised cell line, Cell, Manuscript, IL-6, Brain, Inflammation, R01, Vaccine

Though researchers know that EBV can contribute to the development of MS, the exact mechanisms by which it does so aren’t completely understood.

Key Points: 
  • Though researchers know that EBV can contribute to the development of MS, the exact mechanisms by which it does so aren’t completely understood.
  • As a whole, the group’s findings suggested a mechanism of lytic EBV in MS that promoted inflammation and disease.
  • TAF also significantly reduced the expression of inflammatory cytokines like IL-6 in the SLCLs from the patients with active MS.
  • The funders had no role in study design; data collection and analysis; decision to publish; or preparation of the manuscript.

The Wistar Institute Awarded Second National Science Foundation Grant to Expand Award-winning STEM Training Program

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火曜日, 5月 14, 2024
Ellen, EXceed, Faculty, BTT, Employment, ATE, National Science Foundation, Wistar Institute, Science, Workforce, NSF, CCP, Research, Student, Curriculum, Tri-state, BRT, Knowledge, Biotechnology, Community College of Philadelphia, Community college, Nursing

PHILADELPHIA, PA, May 14, 2024 (GLOBE NEWSWIRE) -- PHILADELPHIA — (May 14, 2024) — The Wistar Institute was awarded a $649,971 grant from the National Science Foundation (NSF) to support the continued expansion of its award-winning Biomedical Technician Training (BTT) Pre-apprenticeship Program .

Key Points: 
  • PHILADELPHIA, PA, May 14, 2024 (GLOBE NEWSWIRE) -- PHILADELPHIA — (May 14, 2024) — The Wistar Institute was awarded a $649,971 grant from the National Science Foundation (NSF) to support the continued expansion of its award-winning Biomedical Technician Training (BTT) Pre-apprenticeship Program .
  • The grant supports Wistar’s reach to community colleges in New Jersey and Delaware who may have limited or no access to hands-on laboratory training and internships.
  • “As the Greater Philadelphia Region’s life science sector continues to expand, there is greater demand for laboratory technicians in both academic and industry labs,” said Dario Altieri, M.D.
  • , president and CEO, director of the Ellen and Ronald Caplan Cancer Center , and the Robert and Penny Fox Distinguished Professor of The Wistar Institute.

Wistar Scientists Discover New Immunosuppressive Mechanism in Brain Cancer

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金曜日, 5月 3, 2024
Cell, National Cancer Institute, Macrophage, Sapienza University of Rome, Genome, Glucose, Wistar Institute, Gene, Brain, Tumor microenvironment, Wistar, Metabolomics, Neuroscience, Immunity, Ben, Medical research, Microglia, Research, Proteomics, Immunology, Histone, Malignancy, Gene expression, Neoplasm, Aurelia, Cancer, Collaborative writing, DSM-IV codes, Prognosis, Immunosuppression, Immunotherapy, Duke School, Disease, GLUT1, Patient, Metabolism, Immune system, Angelica, Vaccine

The lab’s discovery was published in the paper, “ Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma ,” in the journal Immunity.

Key Points: 
  • The lab’s discovery was published in the paper, “ Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma ,” in the journal Immunity.
  • Indeed, monocyte-derived macrophages, but not microglia, blocked the activity of T cells (immune cells that destroy tumor cells), in preclinical models and patients.
  • Glioblastoma is inherently dangerous due to its location in the brain and its immunosuppressive tumor microenvironment, which renders glioblastoma resistant to promising immunotherapies.
  • Note: The work detailed in this publication was initiated at The H. Lee Moffitt Cancer Center during Dr. Veglia’s time there and continued at Wistar.

IMUNON Reports 2023 Financial Results and Provides Business Update

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木曜日, 3月 28, 2024
Transfer, Ovarian cancer, Immunotherapy, Patient, Lung, Vaccine, Good manufacturing practice, Sale, CMC, IND, Bangladesh Technical Education Board, IPR, Investment, Clinical trial, Neoplasm, Research, Primate, DNA, NOL, MD Anderson Cancer Center, Trial of the century, ITT, Safety, MRD, Interim, Silicon Valley Bank, Vaccination, Food, CMOS, Elsevier, CD8, Drug discovery, SVB, CRS, University, Death, SARS-CoV-2, Earnings call, Lassa mammarenavirus, PFS, Immunoglobulin G, FDA, OS, CD4, Temperature, Progression-free survival, COVID-19, Mouse, Messenger, Human, Wistar Institute, Hospital

LAWRENCEVILLE, N.J., March 28, 2024 (GLOBE NEWSWIRE) -- IMUNON, Inc. (NASDAQ: IMNN), a clinical-stage drug-development company focused on developing DNA-mediated immuno-oncology therapies and next-generation vaccines, today reported financial results for the year ended December 31, 2023. The Company also provided an update on its clinical development programs with IMNN-001, a DNA-based interleukin-12 (IL-12) immunotherapy in Phase 2 clinical development for the treatment of first-line, locally advanced-stage ovarian cancer, and on its PlaCCine modality, a proprietary mono- or multi-cistronic DNA plasmid and a synthetic DNA delivery technology for the expression of pathogen antigens in preclinical studies for the development of next-generation vaccines.

Key Points: 
  • “We remain on track to report topline results mid-year from the OVATION 2 Study with IMNN-001 in advanced ovarian cancer.
  • In September 2023, the Company announced interim PFS and OS data with IMNN-001 in its OVATION 2 Study.
  • The Company is hosting a conference call to provide a business update, discuss 2023 financial results and answer questions at 10:00 a.m. Eastern time today.
  • To participate in the call, please dial 866-777-2509 (Toll-Free/North America) or 412-317-5413 (International/Toll) and ask for the IMUNON 2023 Earnings Call.

PCOM, The Wistar Institute Announce Cancer Biology Graduate Program

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水曜日, 3月 20, 2024
Wistar Institute, Drug discovery, Patient, PCOM, Research, News, Cancer, Doctor of Philosophy, Faculty, Student, Drug development, Biomedical sciences, School

Program aimed at advancing research and cultivating the next generation of leaders in the fight against cancer.

Key Points: 
  • Program aimed at advancing research and cultivating the next generation of leaders in the fight against cancer.
  • , Wistar President and CEO, director of its Ellen and Ronald Caplan Cancer Center and the Robert and Penny Fox Distinguished Professor.
  • The Cancer Biology Graduate Program—jointly administered by Wistar and PCOM—will train individuals for a successful academic or industrial career in cancer biology and drug development.
  • At the conclusion of their studies, successful candidates will be granted a Ph.D. in cancer biology from PCOM.

Independent Lab Confirms Immunogenicity and Protection with IMUNON’s IMNN-101 in a Live Virus Challenge Against SARS-CoV-2 Variant XBB.1.5

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木曜日, 2月 29, 2024
Wistar Institute, SARS-CoV-2, Messenger, FDA, Food, Vaccine, Vaccination, Immunoglobulin G, Bangladesh Technical Education Board, Primate, DNA, Mouse

LAWRENCEVILLE, N.J., Feb. 29, 2024 (GLOBE NEWSWIRE) -- IMUNON, Inc. (NASDAQ: IMNN), a clinical-stage drug-development company focused on developing non-viral DNA-mediated immunotherapy and next-generation vaccines, announces positive results from a live virus challenge study conducted for IMUNON by the Wistar Institute with IMNN-101 against the SARS-CoV-2 variant XBB.1.5. This study was conducted using the clinical vector that IMUNON intends to bring into its Phase 1 study during the second quarter and showed IMNN-101 immunogenicity and protective activity in a live viral mouse challenge.

Key Points: 
  • The SARS-CoV-2 XBB.1.5 variant was declared as the variant of concern for the 2023-2024 vaccine by the U.S. Food and Drug Administration (FDA) Vaccines and Related Biological Products Advisory Committee.
  • IMUNON has reported that intramuscular administration of a single dose of IMNN-101 in mice produced IgG neutralizing antibody and T-cell responses.
  • Challenging the mice with live virus 21 days after the second vaccination showed complete protection.
  • Protection in non-human primates was greater than 95%, which is comparable to mRNA.

Wistar Scientists Discover Link Between Leaky Gut and Accelerated Biological Aging

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金曜日, 2月 23, 2024
Methylation, Dysbiosis, Culture, Penn Center, Health, Bacteria, University, Subtypes of HIV, Life Length, Wistar Institute, Bangladesh Technical Education Board, Ileum, Infection, NIH, AIDS, Glass, Metabolomics, Nucleotide, DSM-IV codes, Biomedical Research, HIV/AIDS research, Wistar, University of Pittsburgh, DNA, Immune system, National Institutes of Health, Leiden University Medical Center, Weill Cornell Medicine, Hannum, Research, Inflammation, Blood, Ageing, Cancer, Cell biology, Microbiome, Rush University, HIV, DNA methylation, Vaccine

Dr. Abdel-Mohsen investigates what drives this rapid aging and how to create ways to slow down biological aging and improve health.

Key Points: 
  • Dr. Abdel-Mohsen investigates what drives this rapid aging and how to create ways to slow down biological aging and improve health.
  • A prime suspect in this aging puzzle is the gut microbiome and its potential leakage into the bloodstream.
  • The Abdel-Mohsen lab investigates how gut leakage can impact the immune system and lead to chronic inflammation, which may accelerate aging.
  • Their analysis revealed a significant connection between disrupted gut microbiomes, increased intestinal permeability (leaky gut), and faster biological aging.

Award-Winning Biotech Training Program to Begin Recruitment with New Employer Partner in Life Sciences

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水曜日, 1月 17, 2024
Senior, Wistar Institute, Philadelphia Naval Shipyard, Chamber, Navy, BTT, Literacy, PIDC, Commerce, Partnership, Biomedical Research, Biotechnology, Curriculum, Molecular biology, Interview, GED, Shipyard, Navy Yard, Management

This workforce development training will support the talent needs of the rapidly growing cell and gene therapy manufacturing organization.

Key Points: 
  • This workforce development training will support the talent needs of the rapidly growing cell and gene therapy manufacturing organization.
  • "Our partnership with VintaBio marks an exciting era of Life Science development in Philadelphia.
  • “Where other companies at a similar stage may focus on degreed talent, VintaBio is widening its talent pool to include candidates who complete our training program.
  • Hiring local talent is advantageous at every stage of a company life cycle and we applaud VintaBio for recognizing this and taking action."

Immunitas Therapeutics Appoints Annalisa D'Andrea, Ph.D., as Chief Scientific Officer

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木曜日, 1月 18, 2024
Patient, SRI International, Therapy, Research, Bangladesh Technical Education Board, CSO, Biotechnology, Science, Discovery, University, History, Cancer, Drug discovery, Immunology, Inflammation, Toll-like receptor 9, Wistar Institute, Roche, Pharmaceutical industry

WALTHAM, Mass., Jan. 18, 2024 /PRNewswire/ -- Immunitas Therapeutics ("Immunitas"), a clinical stage precision immunotherapy company committed to discovering and developing novel, differentiated therapeutics for patients with cancer, today announced the appointment of Annalisa D'Andrea, Ph.D., as Chief Scientific Officer (CSO). Dr. D'Andrea has more than 25 years of basic and translational research and development expertise in both large and small pharmaceutical and biotech settings.

Key Points: 
  • Dr. D'Andrea brings more than 25 years of research and development experience to the company, expanding executive leadership team to advance pipeline
    WALTHAM, Mass., Jan. 18, 2024 /PRNewswire/ -- Immunitas Therapeutics ("Immunitas"), a clinical stage precision immunotherapy company committed to discovering and developing novel, differentiated therapeutics for patients with cancer, today announced the appointment of Annalisa D'Andrea, Ph.D., as Chief Scientific Officer (CSO).
  • Dr. D'Andrea brings to Immunitas a strong history of success in immunology therapeutic development, having led products from target selection through clinical evaluation.
  • "Annalisa's leadership and deep drug development expertise has proven invaluable as we advanced our growing pipeline of novel precision immuno-oncology therapeutics over the past several months," said Amanda Wagner, Chief Executive Officer of Immunitas.
  • "We are excited to welcome her as our full-time Chief Scientific Officer.

Wistar Scientists Identify Esophageal Cancer Biomarkers

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水曜日, 12月 6, 2023
RNA, Wistar Institute, Ferroptosis, Collaborative writing, RNA-Seq, National Cancer Institute, Biomedical Research, Culture, Mechanics, Tumor microenvironment, Ellen, Virus, ESCA, Messenger, Prognosis, Health, Ageing, Incidence, Neoplasm, Cancer, International Society, University, University of Pennsylvania, Ecology, Gene expression, Gene, Biomarker, Machine learning, Cell, Patient, Qi, Iron, NCI, Bacteriophage, Esophageal cancer, Carnegie Mellon University

Philadelphia, PA, Dec. 06, 2023 (GLOBE NEWSWIRE) -- Wistar scientists have developed a new tool that can help identify cancer-associated microbes by using machine learning technology.

Key Points: 
  • Philadelphia, PA, Dec. 06, 2023 (GLOBE NEWSWIRE) -- Wistar scientists have developed a new tool that can help identify cancer-associated microbes by using machine learning technology.
  • Under the leadership of Dr. Noam Auslander — assistant professor in the Ellen and Ronald Caplan Cancer Center’s Molecular & Cellular Oncogenesis Program — the group has analyzed short read RNA-sequencing data to detect biomarkers for esophageal carcinoma, or ESCA.
  • Since 1972, the Institute has held National Cancer Institute (NCI)-designated Cancer Center status.
  • Wistar scientists are dedicated to solving some of the world’s most challenging problems in the field of cancer and immunology, advancing human health through early-stage discovery and training the next generation of biomedical researchers.