Gametogenesis

Revolutionary Elephant iPSC Milestone Reached in Colossal’s Woolly Mammoth Project

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Mercoledì, Marzo 6, 2024

Colossal Biosciences (“Colossal”), the world’s first de-extinction company, announces today that their Woolly Mammoth team has achieved a global-first iPSC (induced pluripotent stem cells) breakthrough.

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Colossal Biosciences (“Colossal”), the world’s first de-extinction company, announces today that their Woolly Mammoth team has achieved a global-first iPSC (induced pluripotent stem cells) breakthrough.
This milestone advancement was one of the primary early goals of the mammoth project, and supports the feasibility of future multiplex ex utero mammoth gestation.
Invaluable for Colossal’s Woolly Mammoths, these cells can be multiplex-edited and differentiated to study cold adaptation traits like woolly hair growth and fat storage in cellular and organoid models.
“In the past, a multitude of attempts to generate elephant iPSCs have not been fruitful.

How to grow rhinos in a lab: the science that could save an endangered species

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Domenica, Agosto 13, 2023

With the death of last male in 2018 and with only two females alive, the species is functionally extinct.

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With the death of last male in 2018 and with only two females alive, the species is functionally extinct.
In one of its research lines, the BioRescue team collects mature eggs – scientifically called oocytes – from one of the only two northern white females.
These eggs will be fertilised with frozen sperm that were collected from several northern white male rhinos before their death.
These techniques would not only save the northern white rhinoceros, but also other rhino species, related species with a common ancestor, and all other creatures in need.

Different approaches

Parallel initiatives focusing on different conservation approaches are indispensable to ensure the future of this species.
These supporting cells provide signals and components essential for the development of the eggs.
This would bypass atresia, which is the degradation of follicles that occurs during a natural hormonal cycle.
Due to a scarcity of tissues from endangered species, we are using the pig as a large animal model.
This will give us more in-depth knowledge on how to approach egg creation from stem cells already present in the animal, termed endogenous stem cells.

What next?

Researchers now know that samples of the northern white rhino individuals currently stored in biobanks have enough genetic variability to establish a viable and sustainable population.
This is becoming a reality that gives us hope, motivation and energy to save the northern white rhino.

Colossal Biosciences Secures $150M Series B and Announces Plan to De-Extinct the Iconic Dodo

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Martedì, Gennaio 31, 2023

Hardware, Health Technology, Environmental, Social and Governance (ESG), Technology, Stem Cells, Professional Services, Environment, Environmental Issues, Genetics, Agriculture, Natural Resources, Biotechnology, Science, Software, Research, Health, Gene editing, Synthetic biology, Protein engineering, Colossal Biosciences, United States Air Force Scientific Advisory Board, Save the Elephants, Partnership, Animoca Brands, Multimedia, IUCN Red List, Genome, International Elephant Foundation, Gametogenesis, Cornell Lab of Ornithology, Elephant, Computational biology, George Church, Series, Ecosystem, University, Jim Breyer, Reading, Baylor College of Medicine, Genomics, Mammoth, DNA, Life, Classroom, Bird, Hope, Biology, Genetic engineering, Permafrost, Carbon, Embryology, Dodo, B cell, Duane, Laboratory, Forrest Galante, EEHV, USIT, CRISPR, Biofuel, Biodiversity, Woolly mammoth, University of Alaska Fairbanks, Management, Hunting, Antibiotics, Thylacine, Colossal

View the full release here: https://www.businesswire.com/news/home/20230131005411/en/

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View the full release here: https://www.businesswire.com/news/home/20230131005411/en/
Dr. Beth Shapiro, Ph.D. (Lead Paleogeneticist and Colossal Scientific Advisory Board Member) and Ben Lamm (Colossal Co-Founder and CEO).
Since launching in September 2021, Colossal has raised $225M in total funding.
Colossal is on a mission to reverse these staggering statistics through genetic rescue techniques and its de-extinction toolkit.
Colossal creates innovative technologies for species restoration, critically endangered species protection and the repopulation of critical ecosystems that support the continuation of life on Earth.

TruDiagnostic and North Carolina State University collaborate to fully characterize all imprinting control regions and make testing available on a novel Imprintome epigenetic methylation array.

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Lunedì, Ottobre 24, 2022

For most genes, we inherit two working copies -- one from mom and one from dad. But with imprinted genes, we inherit only one working copy. Depending on the gene, either the copy from mom or the copy from dad is epigenetically silenced.

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LEXINGTON, Ky., Oct. 24, 2022 /PRNewswire/ -- This month, North Carolina State University and TruDiagnostic take the next step in their investigation into the human imprintome with an exclusive license agreement to any diagnostic techniques utilizing imprintome control regions.
Depending on the gene, either the copy from mom or the copy from dad is epigenetically silenced.
This represents the first time in history that these imprint regulatory regions of the genome were fully identified in humans.
Annie Prestrud MPH, TruDiagnotic's Grant and Research Director added; "We encourage anyone working on methylation diagnostics to consider using this Human Imprintome Array."