Memory consolidation

"Ebb and Flow" Brain Mechanism That Drives Learning Identified

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Mercoledì, Agosto 9, 2023

NEW YORK, Aug. 9, 2023 /PRNewswire/ -- Researchers have long thought that rewards like food or money encourage learning in the brain by causing the release of the "feel-good" hormone dopamine, known to reinforce storage of new information. Now, a new study in rodents describes how learning still occurs in the absence of an immediate incentive.

Key Points: 
  • Now, a new study in rodents describes how learning still occurs in the absence of an immediate incentive.
  • Rewards were thought to promote learning by simultaneously triggering an increase in dopamine and a decrease in acetylcholine.
  • This sudden hormone imbalance is believed to open a window of opportunity for brain cells to adjust to new circumstances and form memories for later use.
  • Known as neuroplasticity, this process is a major feature of learning as well as recovery after injury.

Translational Research Describes an Epigenetic Approach for Regulating Fear-Memory

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Lunedì, Agosto 22, 2022

PHILADELPHIA, Aug. 22, 2022 /PRNewswire/ -- EpiVario, Inc., an emerging biotech company developing novel therapeutics for memory-related psychiatric disorders, today highlighted preclinical research findings that could lead to a treatment approach for PTSD. Published in Proceedings of the National Academy of Sciences (PNAS), and co-authored by the academic co-founders of EpiVario, the study demonstrates that fear memories can be controlled through the enzyme acetyl-CoA synthetase 2 (ACSS2). The team also confirmed that a small molecule inhibitor against ACSS2 can block the epigenetic process required for the consolidation of stress and fear memories. 

Key Points: 
  • The team also confirmed that a small molecule inhibitor against ACSS2 can block the epigenetic process required for the consolidation of stress and fear memories.
  • Investigational small molecule compounds were provided by EpiVario, which is developing ACSS2 inhibitors as a therapeutic for memory related neuropsychiatric disorders.
  • "These new results are exciting, as they validate our earlier discovery that ACSS2 is critical for activating genes during the creation of fear memories.
  • These memories are attenuated via epigenetic regulation through the target enzyme acetyl-coA synthetase 2 (ACSS2), which regulates consolidation of fear and drug-craving memories.

CSE Bulletin: Consolidation - Peak Fintech Group Inc. (PKK)

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Martedì, Luglio 27, 2021

Toronto, Ontario--(Newsfile Corp. - Le 27 juillet/July 2021) - Peak Fintech Group Inc. has announced a consolidation of its issued and outstanding common shares on the basis of one (1) post-consolidation common share for every two (2) pre-consolidation common shares.

Key Points: 
  • Toronto, Ontario--(Newsfile Corp. - Le 27 juillet/July 2021) - Peak Fintech Group Inc. has announced a consolidation of its issued and outstanding common shares on the basis of one (1) post-consolidation common share for every two (2) pre-consolidation common shares.
  • As a result, the outstanding shares of the company will be reduced to approximately 80,480,171 common shares.
  • Dealers are reminded to check or re-enter their orders as necessary taking into account the share consolidation.
  • Peak Fintech Group Inc. a annonc une consolidation de ses actions ordinaires mises et en circulation sur la base d'une (1) action ordinaire post-consolidation pour deux (2) actions ordinaires pr-consolidation.

CSE Bulletin: Consolidation - Monterey Minerals Inc. (MREY)

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Venerdì, Luglio 23, 2021

Toronto, Ontario--(Newsfile Corp. - le 23 juillet/July 2021) Monterey Minerals Inc. has announced a consolidation of its issued and outstanding common shares on the basis of one (1) post-consolidation common share for every eighty (80) pre-consolidation common shares.

Key Points: 
  • Toronto, Ontario--(Newsfile Corp. - le 23 juillet/July 2021) Monterey Minerals Inc. has announced a consolidation of its issued and outstanding common shares on the basis of one (1) post-consolidation common share for every eighty (80) pre-consolidation common shares.
  • Please note that all open orders will be cancelled at the close of business on July 23, 2021.
  • Dealers are reminded to re-enter their orders taking into account the share consolidation.
  • Monterey Minerals Inc. a annonc une consolidation de ses actions ordinaires mises et en circulation sur la base d'une (1) action ordinaire post-consolidation pour quatre-vingts (80) actions ordinaires pr-consolidation.

CSE Bulletin: Consolidation - Evolving Gold Corp. (EVG)

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Martedì, Luglio 20, 2021

Toronto, Ontario--(Newsfile Corp. - le 20 juillet/July 2021) Evolving Gold Corp. has announced a consolidation of its issued and outstanding common shares on the basis of one (1) post-consolidation common share for every ten (10) pre-consolidation common shares.

Key Points: 
  • Toronto, Ontario--(Newsfile Corp. - le 20 juillet/July 2021) Evolving Gold Corp. has announced a consolidation of its issued and outstanding common shares on the basis of one (1) post-consolidation common share for every ten (10) pre-consolidation common shares.
  • Please note that all open orders will be cancelled at the close of business on July 21, 2021.
  • Dealers are reminded to re-enter their orders taking into account the share consolidation.
  • Evolving Gold Corp. a annonc une consolidation de ses actions ordinaires mises et en circulation sur la base d'une (1) action ordinaire post-consolidation pour dix (10) actions ordinaires pr-consolidation.

New Zealand Energy Corp. Announces Proposed Share Consolidation

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Martedì, Giugno 22, 2021

Forward-Looking Information: This news release contains "forward-looking information" within the meaning of applicable Canadian securities legislation.

Key Points: 
  • Forward-Looking Information: This news release contains "forward-looking information" within the meaning of applicable Canadian securities legislation.
  • All statements, other than statements of historical fact, included herein are forward-looking information.
  • In particular, this news release contains forward-looking information regarding: the proposed Consolidation.
  • These assumptions include, but are not limited to: the receipt of all necessary approvals for the Consolidation.

CSE Bulletin: Consolidation - New Wave Holdings Corp. (SPOR)

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Venerdì, Giugno 18, 2021

Toronto, Ontario--(Newsfile Corp. - le 17 juin/June 2021) - New Wave Holdings Corp. has announced a consolidation of its issued and outstanding common shares on the basis of one (1) post-consolidation common share for every twenty (20) pre-consolidation common shares.

Key Points: 
  • Toronto, Ontario--(Newsfile Corp. - le 17 juin/June 2021) - New Wave Holdings Corp. has announced a consolidation of its issued and outstanding common shares on the basis of one (1) post-consolidation common share for every twenty (20) pre-consolidation common shares.
  • As a result, the outstanding shares of the company will be reduced to approximately 5,984,245 common shares.
  • Please note that all open orders will be cancelled at the close of business on June 17, 2021.
  • New Wave Holdings Corp. a annonc une consolidation de ses actions ordinaires mises et en circulation sur la base d'une (1) action ordinaire post-consolidation pour vingt (20) actions ordinaires pr-consolidation.

CSE Bulletin: Consolidation - Sentinel Resources Corp. (SNL)

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Giovedì, Maggio 27, 2021

Toronto, Ontario--(Newsfile Corp. - le 27 mai/May 2021) Sentinel Resources Corp. has announced a consolidation of its issued and outstanding common shares on the basis of one (1) post-consolidation common share for every three (3) pre-consolidation common shares.

Key Points: 
  • Toronto, Ontario--(Newsfile Corp. - le 27 mai/May 2021) Sentinel Resources Corp. has announced a consolidation of its issued and outstanding common shares on the basis of one (1) post-consolidation common share for every three (3) pre-consolidation common shares.
  • Please note that all open orders will be cancelled at the close of business on May 28, 2021.
  • Sentinel Resources Corp. a annonc un regroupement de ses actions ordinaires mises et en circulation sur la base d'une (1) action ordinaire post-consolidation pour trois (3) actions ordinaires pr-consolidation.
  • Il est rappel aux concessionnaires de ressaisir leurs commandes en tenant compte de la consolidation des actions.

Alpha Peak Announces Completion of Share Consolidation and Name Change

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Lunedì, Maggio 3, 2021

b'VANCOUVER, British Columbia, May 03, 2021 (GLOBE NEWSWIRE) -- Alpha Peak Capital Inc. (formerly, Alpha Peak Leisure Inc.) (\xe2\x80\x9cAlpha Peak\xe2\x80\x9d or the\xc2\xa0\xe2\x80\x9cCompany\xe2\x80\x9d)\xc2\xa0is pleased to announce that it has altered its notice of articles to change its name to "Alpha Peak Capital Inc." (the "Name Change") and has consolidated its issued and outstanding common shares (the "Common Shares") on the basis of ten (10) pre-consolidation Common Shares for one (1) post-consolidation Common Share (the "Consolidation").

Key Points: 
  • b'VANCOUVER, British Columbia, May 03, 2021 (GLOBE NEWSWIRE) -- Alpha Peak Capital Inc. (formerly, Alpha Peak Leisure Inc.) (\xe2\x80\x9cAlpha Peak\xe2\x80\x9d or the\xc2\xa0\xe2\x80\x9cCompany\xe2\x80\x9d)\xc2\xa0is pleased to announce that it has altered its notice of articles to change its name to "Alpha Peak Capital Inc." (the "Name Change") and has consolidated its issued and outstanding common shares (the "Common Shares") on the basis of ten (10) pre-consolidation Common Shares for one (1) post-consolidation Common Share (the "Consolidation").
  • The Name Change and Consolidation were approved by shareholders of the Company at its annual and special meeting held on April 15, 2021 and came into effect today, on May 3, 2021.
  • A new CUSIP number for the post-consolidation Common Shares has been obtained to replace the previous CUSIP number.\nFollowing the Consolidation, the Company has 7,207,709 Common Shares outstanding.
  • No fractional Common Shares have been issued pursuant to the Consolidation and any fractional shares that would have otherwise been issued have been rounded to the nearest whole Common Share.

Gold Rush Announces Consolidation and Name Change to Allied Copper Corp

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Lunedì, Aprile 5, 2021

Toronto, Ontario--(Newsfile Corp. - April 5, 2021) - Gold Rush Cariboo Corp. (TSXV: GDBO) (OTC: SGRWF) ("Gold Rush" or the "Company") is pleased to announce that it has filed articles of amendment to change its name to "Allied Copper Corp." (the "Name Change") and consolidate its issued and outstanding common shares (the "Common shares") on the basis of fifteen (15) pre-consolidation Common Shares for one (1) post-consolidation Common Share (the "Consolidation").

Key Points: 
  • Toronto, Ontario--(Newsfile Corp. - April 5, 2021) - Gold Rush Cariboo Corp. (TSXV: GDBO) (OTC: SGRWF) ("Gold Rush" or the "Company") is pleased to announce that it has filed articles of amendment to change its name to "Allied Copper Corp." (the "Name Change") and consolidate its issued and outstanding common shares (the "Common shares") on the basis of fifteen (15) pre-consolidation Common Shares for one (1) post-consolidation Common Share (the "Consolidation").
  • The Name Change and Consolidation were approved by shareholders of the Company at its annual and special meeting held on December 2, 2020.
  • The Common Shares are expected to commence trading on the exchange on a consolidated basis under the new name "Allied Copper Corp." on or about April 9, 2021, under the Company's new symbol "CPR".
  • Letters of transmittal with respect to the Name Change and Consolidation are being mailed out to the Company's registered shareholders.