Enlightenment

• “Candel is focused on delivering key value drivers to maximize the impact of its assets and to create substantial value to patients and other stakeholders.
• In 2023, we received Fast Track Designation from the FDA for CAN-2409, our most advanced product candidate, for both NSCLC and pancreatic cancer.
• This platform is open for collaborations with external partners.”
  The Company's strategic prioritization of programs highlights Candel Therapeutics' commitment to operational excellence and efficiency.
• This approach positions the Company for sustained success in the current dynamic market for new cancer therapeutics.

• NWTN exhibit to feature augmented reality interactive experience that guides visitors through the entire clean energy value chain and highlights how NWTN and its partners aim to develop solutions from energy generation to energy storage, and energy utilization.
• DUBAI, UAE, Nov. 27, 2023 /PRNewswire/ -- NWTN Inc. (Nasdaq: NWTN), an eco-conscious mobility technology company bringing passenger-centric green premium mobility solutions to the world ("NWTN" or the "Company"), today announced plans to exhibit, with its partners, technologies for the entire clean energy value chain during COP28 UAE from November 30, 2023 to December 12, 2023 in Dubai, United Arab Emirates.
• The exhibit will feature a unique augmented reality interactive experience that guides visitors through the entire clean energy value chain story, from energy generation to energy storage and energy utilization.
• NWTN is working with its partners to provide and facilitate the clean energy and technology solutions required for rapidly growing economies like the UAE.

• “We aim to leverage artificial intelligence and machine learning to expedite various aspects of drug discovery and development,” said Paul Peter Tak, MD, PhD, FMedSci, President and Chief Executive Officer of Candel.
• “Tumor resistance to immunotherapy is driven by multiple mechanisms, which are heterogeneous in nature,” said Francesca Barone, MD, PhD, Chief Scientific Officer at Candel.
• “The Alpha-201-macro1 preclinical data presented today support the utility of local delivery of an immunologically active, multimodal agent as a potential alternative to systemic therapy.
• We are excited to leverage the enLIGHTEN™ Discovery Platform to optimize the immunostimulatory payload of this agent for activation of innate immune surveillance with the goal of maximizing its therapeutic potential.”
  Further details from the posters are available on the Candel website at: www.candeltx.com/media

• No account of the modern era – not just modern thought – could ignore him.
• But like any major thinker, there are risks in summaries – some of which give us clues about Rousseau himself.
• Although he is known as a social and political philosopher, Rousseau’s creative output does not resemble that of a contemporary “theorist”.
• These are now conventional tropes, but they were only emerging at the time Rousseau was writing.

Natural or artificial

• Rousseau had shot to fame a decade earlier, after winning an essay competition advertised in the literary magazine Mercure de France.
• Where much philosophical discussion had been centred around the distinction between the “natural” and the “supernatural”, Rousseau opposed the natural to the artificial.
• He argued that what we ordinarily think of as civilisational progress creates – and then aims to satisfy – new and artificial vices, serving our vanity and not our natural needs.
• In fact, he proposed there were many good reasons to think they were greater in both.
• Read more:
  Guide to the Classics: Voltaire’s Candide — a darkly satirical tale of human folly in times of crisis

Society and inequality

• Developing these ideas, in 1754, Rousseau wrote his Discourse on the Origin and Basis of Inequality Among Men.
• In it, he attempted a thought experiment which imagined what humans may have been like in a “pre-civilisational” state.
• Rousseau was aware that this act of imagination was speculative and he could not be sure of its results.
• He held that inequality was artificial.

Education and politics

• The first was the institution of a new kind of education; the second was reorienting politics towards a new moral foundation.
• In Émile, or On Education (1862), Rousseau wrote a treatise on education in the form of a bildungsroman – the first and likely the last of its kind.
• He sought to outline the conditions of a good education, which he thought should be based on lived experience and the development of individual character, not rote learning, mechanical memorisation, or even the reading of books.
• As for moral education, young people should learn about the consequences of their actions.
• Rousseau’s terminology has oriented discussions of morality, self-development and politics from the 18th century to the counterculture of the 1960s, the New Age movement of the 1980s, and beyond.

Deism and human nature

• According to Rousseau, we know what we know of God from Nature and Reason alone.
• In Rousseau, Judge of Jean-Jacques (1776), Rousseau addresses this question directly, and in typically Rousseauian fashion:
  whence could the painter and apologist of human nature have taken his model, if not from his own heart?
• He has described this nature just as he felt it within himself.
• whence could the painter and apologist of human nature have taken his model, if not from his own heart?
• He has described this nature just as he felt it within himself.