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Inozyme Pharma Announces Positive Topline Data from Ongoing Phase 1/2 Trials of INZ-701 in Adults with ABCC6 Deficiency (PXE) and ENPP1 Deficiency

Retrieved on: 
Lundi, avril 8, 2024
Patient, Cerebrovascular disease, Stroke, Accelerated approval (FDA), European Medicines Agency, Doctor of Philosophy, Osteomalacia, PROMIS, Therapy, Conditional, Natural history, CTX, Pros, ADAS, Risk, DSM-IV codes, Cohort, Aes, Alkaline phosphatase, Rickets, EMA, PXE, Safety, Epilepsy, Clinical trial, Food, Hospital, Disability, BSAP, Cardiovascular disease, Disease, PD, Paresis, Consultant, Hypophosphatemia, Fatigue, Survivor, Sclera, FDA, Observational study, Pyrophosphate, Choroid, Incidence, Retina, Biomarker, Life, Event, Medical imaging

BOSTON, April 08, 2024 (GLOBE NEWSWIRE) -- Inozyme Pharma, Inc. (Nasdaq: INZY) (“the Company” or “Inozyme”), a clinical-stage rare disease biopharmaceutical company developing novel therapeutics for the treatment of pathologic mineralization and intimal proliferation, today announced positive topline safety, pharmacokinetic (PK), pharmacodynamic (PD) and exploratory efficacy data from the Company’s ongoing Phase 1/2 clinical trials of INZ-701 in adults with ABCC6 Deficiency (PXE, pseudoxanthoma elasticum) and ENPP1 Deficiency.

Key Points: 
  • “We are excited by the excellent safety and preliminary efficacy profile of INZ-701 in adults with ABCC6 Deficiency,” said Douglas A. Treco, Ph.D., CEO of Inozyme Pharma.
  • The patients were assigned to three dose cohorts of INZ-701: 0.2 mg/kg (n=3), 0.6 mg/kg (n=3), and 1.8 mg/kg (n=4).
  • For trial design details, please see the section entitled “INZ-701 in ABCC6 Deficiency Phase 1/2 Clinical Trial Design” below.
  • For trial design details, please see the section entitled “INZ-701 in ENPP1 Deficiency Phase 1/2 Clinical Trial Design” below.

Applied Therapeutics to Present Results from Phase 3 ARISE-HF Study in Diabetic Cardiomyopathy at ACC 2024

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Jeudi, avril 4, 2024
Diabetic cardiomyopathy, Patient, Journal, Diabetes, American College, Treatment, Therapy, Safety, ACC, JACC, Pharmaceutical industry

The presentation at ACC will also include important data on progression to overt heart failure and other secondary outcome measures.

Key Points: 
  • The presentation at ACC will also include important data on progression to overt heart failure and other secondary outcome measures.
  • AT-001 treatment prevented progression to overt heart failure in patients with DbCM as compared to placebo (p=0.0285).
  • The oral presentation at ACC will be followed by simultaneous publication of the study results in the Journal of the American College of Cardiology Journal (JACC).
  • A Selective Aldose Reductase Inhibitor (AT-001) For the Treatment of Diabetic Cardiomyopathy: Primary Results of the Phase 3 Randomized Controlled ARISE-HF Study
    Monday, April 8, 2024, 8:30 – 9:45 am ET, Main Tent (Hall B1)

INVNT GROUP™ Presents Mad Dog Jones’ Newest NFT Collection 'Fallen Gravity': Cyberpunk Art and Star Songs Collide in collaboration with INVNT.ATOM™, Artemis Music Entertainment, and Nifty Gateway

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Mercredi, avril 3, 2024
Open Edition, Apollo program, Limited Edition, Algorithm, Nifty Gateway, Music, Blockchain, Star Music, International Space Station, History, EDT, NFT, Sale, Mission control center, Orbit, Collection, Non-fungible token, Telemetry, Senior producer, Extraterrestrial life, ISS, Star Song Communications, Gravity, Dream, Creativity, Communications satellite

On his inspiration for the project, Mad Dog Jones comments, “Fallen Gravity is about drifting into the unknown.

Key Points: 
  • On his inspiration for the project, Mad Dog Jones comments, “Fallen Gravity is about drifting into the unknown.
  • The Star Songs are created utilizing data sonification algorithms that convert astronomical images into audible music, mapping characteristics of the stars.
  • The custom Star Songs are integrated with the NFTs to celebrate and honor the duration of the International Space Station’s journey.
  • We’re proud to launch this mission, brought to life with our brilliant collaborators and partners, Mad Dog Jones, Artemis Music Entertainment, and Nifty Gateway.

Medigene AG Reports Full-Year 2023 Financial Results and Provides Corporate Update

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Jeudi, mars 28, 2024
Research, EUR, Ovarian cancer, Q&A, Partnership, BioNTech, Webcast, Patient, Co-stimulation, G&A, Synovial sarcoma, HLA, AACR, Clinical trial, Therapy, ESMO, Depreciation, Safety, TCR, Patent, Stomach, USD

Medigene AG (Medigene or the “Company”, FSE: MDG1, Prime Standard), an immuno-oncology platform company focusing on the discovery and development of T cell immunotherapies for solid tumors, today reported financial results for the fiscal year ended December 31, 2023, and provided a corporate update.

Key Points: 
  • Medigene AG (Medigene or the “Company”, FSE: MDG1, Prime Standard), an immuno-oncology platform company focusing on the discovery and development of T cell immunotherapies for solid tumors, today reported financial results for the fiscal year ended December 31, 2023, and provided a corporate update.
  • General and administrative (G&A) expenses were EUR 9.3 million in 2023 compared to EUR 7.7 million in the year prior.
  • First pre-clinical data on MDG2011 was presented at the ESMO Congress 2023 and the SITC Annual Meeting 2023.
  • As of Dec 31, 2023, Medigene’s IP portfolio consisted of 112 issued and 131 pending patents across 28 patent families.

Erasca Reports Fourth Quarter 2023 and Full Year 2023 Business Updates and Financial Results

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Mercredi, mars 27, 2024
Administration, EGFR, Mutation, Index, Colorectal cancer, Cetuximab, Central nervous system, Novartis, Webcast, Patient, GBM, CNS, Neoplasm, Acquisition, G&A, Insurance, BRAF, NRAS, MEK, CRC, Melanoma, ASCO, ID, MTD, Research and development, Probability, Data, FDA, Outsourcing, FTD, Pharmaceutical industry

SAN DIEGO, March 27, 2024 (GLOBE NEWSWIRE) -- Erasca, Inc. (Nasdaq: ERAS), a clinical-stage precision oncology company singularly focused on discovering, developing, and commercializing therapies for patients with RAS/MAPK pathway-driven cancers, today provided business updates and reported financial results for the fiscal quarter and full year ended December 31, 2023.

Key Points: 
  • In addition, a strategic pipeline prioritization sharpened Erasca’s focus on existing programs that we believe have the highest probability of success for patients.
  • Research and Development (R&D) Expenses: R&D expenses were $24.8 million for the quarter ended December 31, 2023, compared to $29.4 million for the quarter ended December 31, 2022.
  • General and Administrative (G&A) Expenses: G&A expenses were $9.1 million for the quarter ended December 31, 2023, compared to $8.7 million for the quarter ended December 31, 2022.
  • Erasca will hold a conference call and webcast on Thursday, March 28, 2024 at 8:30 am ET.

Altimmune Announces Positive Lean Mass Preservation Data for Pemvidutide and Reports Fourth Quarter and Full Year 2023 Financial Results

Retrieved on: 
Mercredi, mars 27, 2024
Research, Blood pressure, Body composition, LDL, Adipose tissue, Obesity, Development, Cirrhosis, Three Months, Exercise, Arrhythmia, Hepatitis B virus, Diabetes, Lipid, Patient, Heart rate, Fast Track, Weight loss, Sarcopenia, MASH, Woman, Diet, Investment, Fibrosis, Safety, Optimism, FDA, Triglyceride, IMPACT, Dietary supplement

“We are extremely pleased with the results of the body composition analysis from our recently completed MOMENTUM 48-week Phase 2 obesity trial of pemvidutide.

Key Points: 
  • “We are extremely pleased with the results of the body composition analysis from our recently completed MOMENTUM 48-week Phase 2 obesity trial of pemvidutide.
  • “There is a growing appreciation that the quality of weight loss is as important as the quantity of weight loss.
  • Achieved mean weight loss of 15.6% on 2.4 mg dose of pemvidutide at week 48, with weight loss continuing at the end of treatment.
  • Financial Results for the Three Months Ended December 31, 2023
    Altimmune had cash, cash equivalents and short-term investments totaling $198.0 million at December 31, 2023.

Inozyme Pharma to Report Topline Data from Ongoing Phase 1/2 Trials of INZ-701 in Adults with ABCC6 Deficiency and ENPP1 Deficiency on April 8, 2024

Retrieved on: 
Mardi, mars 26, 2024
Neurology, Hospital, Consultant, Webcast, Patient, PXE, Event, Therapy, Pharmaceutical industry

BOSTON, March 26, 2024 (GLOBE NEWSWIRE) -- Inozyme Pharma, Inc. (Nasdaq: INZY) (“the Company” or “Inozyme”), a clinical-stage rare disease biopharmaceutical company developing novel therapeutics for the treatment of pathologic mineralization and intimal proliferation, today announced that it will host a conference call and webcast on Monday, April 8, 2024 at 8:00 a.m. Eastern Time.

Key Points: 
  • - Company to host conference call and webcast featuring key opinion leaders on Monday, April 8, 2024 at 8:00 a.m.
  • During the conference call and webcast, the Company will discuss topline data from its ongoing Phase 1/2 trial of INZ-701 in adults with ABCC6 Deficiency (pseudoxanthoma elasticum or PXE), and from all cohorts of its ongoing Phase 1/2 trial of INZ-701 in adults with ENPP1 Deficiency.
  • Alternatively, the conference call may be accessed by dialing:
    Participants should ask to join the Inozyme Pharma call.
  • For those unable to participate live, a replay will be available in the Investor Relations section of Inozyme’s website for a limited time following the event.

Cognition Therapeutics Reports Year End 2023 Financial Results and Provides Business Update

Retrieved on: 
Mardi, mars 26, 2024
Research, Corporation, Conference, DLB, Alzheimer's disease, Disease, Biomarker, Public expenditure, Translational Neurodegeneration, Completeness, Vance DeGeneres, Protein, Clinical trial, Quantitative electroencephalography, Therapy, NIA, SHIMMER, Cognition, Pharmaceutical industry

PURCHASE, N.Y., March 26, 2024 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc. (Nasdaq: CGTX), a clinical stage company developing product candidates that treat neurodegenerative disorders, (the “Company” or “Cognition”), today reported financial results for the fourth quarter and full year ended December 31, 2023, and provided a business update. Management will host a live webcast conference call at 8:00am ET to review 2023 accomplishments. Details of the call are provided below.

Key Points: 
  • ET -
    PURCHASE, N.Y., March 26, 2024 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc. (Nasdaq: CGTX), a clinical stage company developing product candidates that treat neurodegenerative disorders, (the “Company” or “Cognition”), today reported financial results for the fourth quarter and full year ended December 31, 2023, and provided a business update.
  • Cognition scientists published two manuscripts and made 11 presentations at medical and scientific congresses in 2023, advancing the understanding of its foundational science and clinical implications.
  • “We achieved a number of critical clinical objectives in 2023,” said Lisa Ricciardi, Cognition’s president and CEO .
  • Management will host a conference call and live webcast to discuss Cognition’s financial results today at 8:00 a.m.

C3is Inc. reports Revenue of $13.8 million, Net Income of $5.6 million and $0.25 earnings per diluted share for the fourth quarter of 2023, and financial and operating results for the quarter and twelve months ended December 31, 2023

Retrieved on: 
Mardi, mars 26, 2024
Administration, Environment, EPS, Webcast, CISS, Imperial, Acquisition, Transport, Depreciation, Interest, TCE, Asset, Calendar, Airline

Voyage revenues of $28.7 million for the twelve months ended December 31, 2023, corresponding to a daily TCE1 of $23,453.

Key Points: 
  • Voyage revenues of $28.7 million for the twelve months ended December 31, 2023, corresponding to a daily TCE1 of $23,453.
  • Our Company generated a net income of $9.3 million for the twelve months ended December 31, 2023, and a net income of $5.6 million for the three months ended December 31, 2023.
  • 69.7% increase in Net Income to $5.6 million for the three months ended December 31, 2023, from $3.3 million for the three months ended September 30, 2023.
  • 45.3% increase in EBITDA2 to $7.7 million for the three months ended December 31, 2023, from $5.3 million for the three months ended September 30, 2023.

European Parliament Recognizes Essential Tremor as Official Disease in Ground-Breaking Declaration

Retrieved on: 
Mardi, avril 9, 2024
European Parliament, Myenteric plexus, Movement disorder, Environment, Disease, Social justice, Patient, DSM-IV codes, Joint Declaration, Hope, Quality of life, Parliament, Essential tremor, European, Geography, Insightec, Pharmaceutical industry

BRUSSELS, April 9, 2024 /PRNewswire/ -- The European Parliament, in collaboration with Insightec and patient advocacy groups, has taken a historic step forward in the healthcare realm by signing a Joint Declaration to officially recognize essential tremor as a disease. This monumental move promises to enhance the lives of millions who suffer from the most common movement disorder worldwide, affecting an estimated 54 million people.

Key Points: 
  • The Joint Declaration specifically calls for the following:
    The formal recognition of essential tremor as a distinct disease.
  • "Access to treatment options for essential tremor is a matter of equality and social justice," echoes Maarit Matjussi, chair of ScanShakers and chairwoman of the Finnish Essential Tremor Association.
  • "Signing this Joint Declaration, together with Members of the European Parliament and patient associations across Europe, is a pivotal milestone for Insightec and for people living with essential tremor across Europe.
  • Members of the European Parliament, Insightec, and patient groups are united in their commitment to ensuring equal therapy access and improving quality of life for all affected by this disease.