Non-Euclidean geometry

Fragrance ingredient exposure is orders of magnitude below thresholds of concern, study shows

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Mardi, février 6, 2024

Toxicity, Research institute, EFSA, DST, Trauma surgery, Food, Inhalation, Non-Euclidean geometry, Doctor of Philosophy, TTC, Perfume

MAHWAH, N.J., Feb. 6, 2024 /PRNewswire/ -- The Research Institute for Fragrance Materials, Inc. (RIFM), in collaboration with scientific modeling, data analytics, and computing company Creme Global, compared the fragrance exposure of the highest-end product users to the Threshold of Toxicological Concern (TTC) and Dermal Sensitization Threshold (DST) to determine a realistic understanding of consumer exposure to fragrance. The TTC is based on the U.S. Food and Drug Administration's Threshold of Regulation, which it expands upon to include consideration of an ingredient's molecular structure in conjunction with its toxicity data. The TTC approach is internationally recognized by regulators including the European Food Safety Authority (EFSA).

Key Points:

The TTC approach is internationally recognized by regulators including the European Food Safety Authority (EFSA) .
The study authors compared exposure to the approximately 3,000 in-use fragrance-producing ingredients to their respective TTCs and DSTs.
Representative fragrance ingredients were randomly selected and analyzed for exposure distribution by product type (i.e., personal, household, oral, and air care) and route of exposure.
Exposure calculations were performed by the Creme-RIFM Aggregate Exposure model, which provides realistic exposure estimates that consider all fragrances the population is exposed to across all products used.

Chevron Lummus Global and Hongrun Petrochemical Successfully Commission The World's Largest All-Hydroprocessing White Oil Unit

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Mercredi, janvier 31, 2024

CLG, Cosmetics, MTPA, Food, White, Mineral oil, Non-Euclidean geometry

RICHMOND, Calif., Jan. 31, 2024 /PRNewswire/ -- Chevron Lummus Global LLC (CLG) today announced the successful commissioning of the world's largest white oil hydroprocessing unit for Hongrun Petrochemical (Weifang) Co., Ltd. in Weifang, Shandong Province, China.

Key Points:

RICHMOND, Calif., Jan. 31, 2024 /PRNewswire/ -- Chevron Lummus Global LLC (CLG) today announced the successful commissioning of the world's largest white oil hydroprocessing unit for Hongrun Petrochemical (Weifang) Co., Ltd. in Weifang, Shandong Province, China.
The new plant, which utilizes CLG's ISODEWAXING and ISOFINISHING technologies, consists of two units: a 500,000 metric tons per annum (MTPA) nameplate capacity API Group III lubricating base oil unit with the capability to produce industrial-grade white oil, and a 200,000 metric tons per annum nameplate capacity food grade white oil unit.
White oil is a highly refined mineral oil that is used in a wide variety of applications, including pharmaceuticals, cosmetics, food processing and industrial lubricants.
Food-grade white oil is a special type of white oil that is manufactured to meet the strict purity requirements of the food and beverage industry.

NexCore Group Opens New HATCHspaces® Life Science Building in Boulder, Colorado

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Mercredi, janvier 24, 2024

Denver, Jan. 24, 2024 /PRNewswire-PRWeb/ -- NexCore Group and its subsidiary, HATCHspaces, have marked the inauguration of HATCHlabs @ Wilderness Place in Boulder, Colorado, on January 17, 2024. Situated at 2880 Wilderness Place and representing the successful conversion of the historic Boulder Beer Company Brewery building into an innovative hub for emerging companies in the life sciences industry. This project marks the ninth project overall for the HATCHspaces brand and the fourth under the NexCore Science & Technology platform.

Key Points:

This project marks the ninth project overall for the HATCHspaces brand and the fourth under the NexCore Science & Technology platform .
In order for life science clusters to grow, functional and affordable graduation lab space needs to be available for startups emerging from academic labs and incubators.
"In order for life science clusters to grow, functional and affordable graduation lab space needs to be available for startups emerging from academic labs and incubators.
"Huge kudos to HATCHspaces and NexCore Group for selecting Colorado as a key market.

GIST Researchers Optimize the Performance of Novel Organic Electrochemical Transistors

Retrieved on:

Jeudi, janvier 18, 2024

Artificial intelligence, Advanced Materials, Research, Professor, Attention, OECT, Computer, Non-Euclidean geometry, Noetics, Electron, Ethylene glycol, Semiconductor

The steady-state performance of OECTs can be optimized by using both molecular design and structural alignment together to reduce the energetic and microstructural disorders in the films.

Key Points:

The steady-state performance of OECTs can be optimized by using both molecular design and structural alignment together to reduce the energetic and microstructural disorders in the films.
Talking to us about the rationale behind conducting this study, Prof. Yoon says, "Using mixed conductors in electrochemical transistors makes it difficult to expect significant performance improvements, even when applying conventional microstructure control processes.
Organic mixed conductors are among the most promising materials in this field, with high potential for advancement.
Our research forms a part of the efforts to overcome the low performance of organic materials."

Aprea Therapeutics Provides Corporate Update and Announces Development Plans for 2024

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Jeudi, janvier 4, 2024

ATR, Aplastic anemia, IND, DDR, Principal, FDA, Spacecraft, Breast, WEE1, Data, APRE, PLK1, PLK, PLK2, Complex conjugate, HERG, Therapy, Pharmacokinetics, PLK3, Cancer, PARP, Prostate, Toxicity, Patient, Safety, Non-Euclidean geometry, ADC, NSCLC, History, Pharmaceutical industry

DOYLESTOWN, Pa., Jan. 04, 2024 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE) (“Aprea”, or the “Company”), a clinical-stage biopharmaceutical company focused on precision oncology through synthetic lethality, today provided a corporate update highlighting recent developments and plans for advancement of its pipeline of DNA Damage Response (DDR) anti-cancer agents in 2024.

Key Points:

DOYLESTOWN, Pa., Jan. 04, 2024 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE) (“Aprea”, or the “Company”), a clinical-stage biopharmaceutical company focused on precision oncology through synthetic lethality, today provided a corporate update highlighting recent developments and plans for advancement of its pipeline of DNA Damage Response (DDR) anti-cancer agents in 2024.
The most recent analysis of the data cut (January 2, 2024) shows that two patients have achieved stable disease – one each in the 50 mg and 200 mg cohorts.
Upon the addition of the higher dose cohorts, Aprea expects to determine the recommended Phase 2 dose (RP2D) in the second half of 2024.
Aprea will be hosting institutional investor and business development meetings at the Annual Corporate Access Event in San Francisco, hosted by our investor relations firm LifeSci Partners.

ECB appoints Thijs van Woerden as Director General Horizontal Supervision

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Mercredi, janvier 3, 2024

Frankfurt, Board of directors, DNB, Non-Euclidean geometry, Central bank, Accenture, University, Directorate, Reproduction, Insurance, De Nederlandsche Bank, European Central Bank, Communication, Economics, Policy, ECB, Management

- PRESS RELEASE

Key Points:

- PRESS RELEASE
ECB appoints Thijs van Woerden as Director General Horizontal Supervision
12 December 2023
- Thijs van Woerden has over 25 years’ experience in banking and insurance supervision
- Business area develops supervisory methodologies and policies, conducts industry-wide assessments
The Executive Board of the European Central Bank has appointed Thijs van Woerden as Director General Horizontal Line Supervision.
In his new role Mr van Woerden will be responsible for providing the strategic direction of and managing horizontal line supervision.
Alongside other areas of European banking supervision, this business area helps to develop and nurture a common understanding and coordinated approach to supervisory tasks.
The thematic supervisory teams of the Directorate General Horizontal Line Supervision perform horizontal tasks relating to all banks subject to European banking supervision.

U.S. Neurologists Eagerly Await Promising Oral Bruton’s Tyrosine Kinase Inhibitors in Multiple Sclerosis Treatment Pipeline, Though Recent Trial Readouts Might Hamper Initial Excitement

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Mercredi, décembre 13, 2023

AB, Traffic barrier, HCP, FDA, Multiple sclerosis, RealTime, Neurology, BTK, Merck Serono, Patient, Safety, Non-Euclidean geometry, RMS, Pharmaceutical industry

Exton, PA, Dec. 13, 2023 (GLOBE NEWSWIRE) -- Several clinical trials are underway for Bruton’s tyrosine kinase inhibitors (BTKi) targeting relapsing and progressive multiple sclerosis (RMS/PPMS).

Key Points:

Exton, PA, Dec. 13, 2023 (GLOBE NEWSWIRE) -- Several clinical trials are underway for Bruton’s tyrosine kinase inhibitors (BTKi) targeting relapsing and progressive multiple sclerosis (RMS/PPMS).
As orally administered BTKis are already established in oncology, there was a notable level of awareness, familiarity, and anticipation surrounding these developmental assets amongst neurologists.
Through Spherix’s quarterly RealTime Dynamix™ market tracker, neurologists and MS specialists have expressed an increasing level of enthusiasm for these investigational therapies over time.
With the recent trial outcomes impacting two of the prominent BTKis in development, the optimistic prospects for this class now face uncertainty.

Skye Bioscience Treats First Patient in Glaucoma Phase 2 Study of SBI-100 Ophthalmic Emulsion

Retrieved on:

Mardi, novembre 28, 2023

SBI-100 OE is a synthetic prodrug of tetrahydrocannabinol (“THC”) that is able to bind and activate CB1 receptors in key ocular tissues.

Key Points:

SBI-100 OE is a synthetic prodrug of tetrahydrocannabinol (“THC”) that is able to bind and activate CB1 receptors in key ocular tissues.
We are advancing the next generation of investigational drugs targeting the endocannabinoid system’s CB1 receptor,” said Punit Dhillon, Skye’s CEO and Chairman.
“This Phase 2 study provides an avenue to confirm IOP-lowering ability and advance the potential for SBI-100 OE in treating ophthalmic disorders.
In preclinical studies involving three different species, SBI-100 OE lowered IOP to a level and duration that compared favorably to the standard of care for treating glaucoma.

Wood-plastic Composites Market worth $11.9 billion by 2028 - Exclusive Report by MarketsandMarkets™

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Jeudi, décembre 21, 2023

Linear low-density polyethylene, UFP Industries, LLDPE, LDPE, HDPE, Non-Euclidean geometry, Wood-plastic composite

Building & construction applications hold the largest share the of Wood-Plastic Composites Market.

Key Points:

Building & construction applications hold the largest share the of Wood-Plastic Composites Market.
Wood-plastic composites offers long shell life that makes them better option than wood composites.
In North America, the high usage of wood-plastic composites is driven by its high usage in decking, fencing, railings, and others.
Many recent technological developments in the use of wood-plastic composites in the automotive component's application is further driving the demand of wood-plastic composites in the region.

Wood-plastic Composites Market worth $11.9 billion by 2028 - Exclusive Report by MarketsandMarkets™

Retrieved on:

Jeudi, décembre 21, 2023

Linear low-density polyethylene, UFP Industries, LLDPE, LDPE, HDPE, Non-Euclidean geometry, Wood-plastic composite

Building & construction applications hold the largest share the of Wood-Plastic Composites Market.

Key Points:

Building & construction applications hold the largest share the of Wood-Plastic Composites Market.
Wood-plastic composites offers long shell life that makes them better option than wood composites.
In North America, the high usage of wood-plastic composites is driven by its high usage in decking, fencing, railings, and others.
Many recent technological developments in the use of wood-plastic composites in the automotive component's application is further driving the demand of wood-plastic composites in the region.