Obstruction

• SOUTH SAN FRANCISCO, Calif., May 08, 2024 (GLOBE NEWSWIRE) -- Cytokinetics, Incorporated (Nasdaq: CYTK) today announced that CEDAR-HCM (Clinical Evaluation of Dosing with Aficamten to Reduce Obstruction in a Pediatric Population in HCM), a clinical trial of aficamten in a pediatric population with symptomatic obstructive hypertrophic cardiomyopathy (HCM), is open to enrollment.
• Aficamten is a next-in-class cardiac myosin inhibitor in development for the potential treatment of HCM.
• HCM can present similarly in adolescents and children as it does in adults and may negatively impact overall quality of life.
• Patients will be randomized on a 2:1 basis to receive aficamten or placebo, and those receiving aficamten will begin with 5 mg dosed once daily.

• MELBOURNE, Australia, April 16, 2024 (GLOBE NEWSWIRE) -- Clinical stage pharmaceutical development company, Incannex Healthcare Inc. (NASDAQ: IXHL), (‘Incannex’ or the ‘Company’), is pleased to provide quarterly activities update and for the quarter ended 31 March 2024.
• Incannex is undertaking various U.S. Food and Drug Administration (‘FDA’) research and development (‘R&D’) programs for cannabinoid pharmaceutical products and psychedelic medicine therapies.
• During the quarter, Incannex released top line results from the PsiGAD1 clinical trial conducted at Monash University, based in Melbourne, Australia.
• This announcement has been approved for release to NASDAQ by the Incannex Board of Directors.

• Simultaneously, Nothing announced it will enhance its overall user experience with industry-first ChatGPT integrations in its audio and smartphone products.
• A refinement of Ear (2), Ear preserves and evolves Nothing's iconic transparent earbud design to deliver the company's best-ever audio experience, delivering richer sound without compromising on performance.
• Ear supports the LHDC 5.0 and LDAC codec for high-resolution streaming over Bluetooth, resulting in powerfully pure audio.
• In the UK, customers can walk away with Ear and Ear (a) at the Nothing Store Soho celebration on 20 April.

• But the nearly two-year investigation into alleged Russian interference in the 2016 U.S. presidential election dominated headlines – and revealed what has become Trump’s trademark denial of any wrongdoing.
• For Trump, the Russia investigation was the first “ridiculous hoax” and “witch hunt.” Mueller didn’t help matters.
• “While this report does not conclude that the president committed a crime, it also does not exonerate him,” the special counsel stated.

1. Obstruction of justice

• But Orentlicher wrote that obstruction of justice is “a complicated matter.” According to federal law, obstruction occurs when a person tries to impede or influence a trial, investigation or other official proceeding with threats or corrupt intent.
• But in a March 24, 2019, letter to Congress summarizing Mueller’s findings, then-Attorney General William Barr said he saw insufficient evidence to prove that Trump had obstructed justice.

So it was up to Congress to further a case against Trump on obstruction charges, but then-Speaker of the House Nancy Pelosi declined, arguing that it would be too divisive for the nation and Trump “just wasn’t worth it.”

Read more:
Trump and obstruction of justice: An explainer

2. Why didn’t the full report become public?

• Charles Tiefer is a professor of law at the University of Baltimore and expected that Trump and Barr would do “everything in their power to keep secret the full report and, equally important, the materials underlying the report.” Tiefer was right.
• To keep Mueller’s report private, Barr invoked grand jury secrecy – the rule that attorneys, jurors and others “must not disclose a matter occurring before the grand jury.”

Trump and Barr also claimed executive privilege to further prevent the release of the report. Though it cannot be used to shield evidence of a crime, Tiefer explained, “that’s where Barr’s exoneration of Trump really helped the White House.”

Read more:
How Trump and Barr could stretch claims of executive privilege and grand jury secrecy

3. Alternative facts

• Perhaps the most disappointing finding, they argued, is that there are no known fixes to this problem.
• They found that fact-checking has little impact on changing individual beliefs, and more education only sharpens the divisions.
• And with that, they wrote, “the U.S. continues to inch ever closer to a public square in which consensus perceptions are unavailable and facts are irrelevant.”

  Read more:
  From 'Total exoneration!'

4. Trump’s demand for loyalty

• What sets Trump apart, Ouyang wrote, is his “exceptional emphasis on loyalty.” Trump expects personal loyalty from his staff – especially from his attorney general.
• “Trump values loyalty over other critical qualities like competence and honesty.
• Read more:
  Why does a president demand loyalty from people who work for him?