Carotenoid

• Wegovy, Ozempic and Mounjaro are weight loss and diabetes drugs that have made quite a splash in health news.
• They target regulatory pathways involved in both obesity and diabetes and are widely considered breakthroughs for weight loss and blood sugar control.
• Here’s an inside-out perspective on the role natural gut hormones and healthy food play in metabolism and weight loss.

A broken gut

• These include GLP-1, a natural version of Wegovy and Ozempic.
• GLP-1 and other hormones like PYY help regulate blood sugar through the pancreas.

• Prior to modern processed foods, metabolic regulatory pathways were under the direction of a diverse healthy gut microbiome that used these hormones to naturally regulate your metabolism and appetite.
• Removal of these key food components and the resulting decrease in gut microbiome diversity may be an important factor contributing to the rise in obesity and diabetes.

A short track to metabolic health

• Researchers have demonstrated their effectiveness at weight loss and blood sugar control.
• These drugs complement other measures like gastric bypass surgery that are used in the most extreme cases of metabolic disease.
• Medical guidelines support the use of new incretin-based medications like Wegovy, Ozempic and Mounjaro to manage the interrelated metabolic conditions of diabetes, obesity and cardiovascular disease.

A near-magic bullet – for the right folks

Despite the success and prospect of these drugs to help populations that may benefit most from them, current prescribing practices have raised some questions. Should people who are only a little overweight use these drugs? What are the risks of prescribing these drugs to children and adolescents for lifelong weight management?

• These symptoms are related to how the drugs work to slow the gastrointestinal tract.
• Other more severe, but rare, side effects include pancreatitis and irreversible gastroparesis, or inflammation of the pancreas and stomach paralysis.

All roads lead to lifestyle

• Despite our greatest aspirations for quick fixes, it’s very possible that a healthy lifestyle remains the most important way to manage metabolic disease and overall health.
• This includes regular exercise, stress management, sleep, getting outdoors and a balanced diet.

Christopher Damman is on the scientific advisory board at One BIO and Supergut.

• These nutrients are carefully calibrated to improve skin barrier function from the inside out.
• To understand the benefits of Lumenato on skin structure, 59 healthy women between ages 35-55 of varying ethnicities (Caucasian, Latino) and skin types (II, III, IV) were studied.
• With Lumenato supplementation participants saw a 10.4% reduction in TEWL, while skin barrier strength improved by 59.9%, meaning more resilient, supple and radiant skin.
• It not only improves internal systems like collagen and ceramide protection but ripples outward to the skin barrier for skin radiance and glow.

• Beta-carotene, classified as a provitamin A carotenoid, plays a significant role in this growth.
• This unique carotenoid serves as a precursor to vitamin A, enzymatically converting into retinol, an active vitamin A form.
• Moreover, beta-carotene imparts a vibrant yellow to orange color to various fruits and vegetables, including carrots, sweet potatoes, and pumpkins.
• Food & beverage end-use segment leading the market (30.1% revenue share in 2022) with adoption in breakfast cereals, nutritional drinks, and smoothies.

• NEW YORK, Oct. 4, 2023 /PRNewswire/ -- Elysium Health, Inc.™, a leading life sciences company focused on aging research, today announced the launch of MOSAIC™, a novel, clinically proven daily softgel for skin aging that strengthens and protects the skin from the inside-out.
• Working throughout the layers of the skin, Mosaic leverages the rapidly growing body of research around a class of phytonutrients known as carotenoids, which combat both internal and external stressors that drive skin aging.
• In a single daily softgel, Mosaic takes a whole-body approach to skin care, providing a foundation to target intrinsic and extrinsic skin aging and combating it throughout the layers of the skin.
• Dr. Richard Granstein is a member of the Elysium Health Scientific Advisory Board and holds equity in Elysium Health.