Neutrophil

Inflammation Marker Signifies Increased Mortality Risk, Finds New Study in PLOS ONE

Retrieved on: 
星期三, 八月 2, 2023

SECAUCUS, N.J., and BOCA RATON, Fla., Aug. 2, 2023 /PRNewswire/ -- The higher the level of a marker of inflammation in circulating blood, the greater the risk of dying from a range of medical disorders, according to a new study published in PLOS ONE. The analysis is the first to demonstrate that lowering levels of myeloperoxidase, or MPO, a marker of chronic inflammation traditionally associated with heart disease, may help provide insight into an individual's mortality risks from a range of diseases beyond heart disease. With these insights, individuals with their healthcare providers may be able to take more aggressive actions to lower personal risk.

Key Points: 
  • With these insights, individuals with their healthcare providers may be able to take more aggressive actions to lower personal risk.
  • As part of the MDVIP Annual Wellness Program, physicians provide their patients MPO screening based on a Quest MPO blood test.
  • The researchers also noted MPO's performance in the study raises the prospect it may be a more specific predictor of mortality than high-sensitivity CRP, a well-established marker of inflammation described in other research.
  • The center's multi-marker approach of adding inflammation-specific tests to traditional lipid testing provides additional insight into an individual's cardiovascular risk.

What happens in our body when we encounter and fight off a virus like the flu, SARS-CoV-2 or RSV?

Retrieved on: 
星期五, 七月 28, 2023

They spread from person to person through respiratory droplets when someone coughs, sneezes, or talks and can cause death in serious cases.

Key Points: 
  • They spread from person to person through respiratory droplets when someone coughs, sneezes, or talks and can cause death in serious cases.
  • But what happens in our body when we first encounter these viruses?

First line of defence

    • When we encounter respiratory viruses, the first line of defence is the physical and chemical barriers in our nose, upper airways, and lungs.
    • Our defence also includes our behaviours such as coughing or sneezing.

Patrolling for potential invaders

    • The cells of innate immunity act like a patrol system, searching for any invaders.
    • These innate cells patrol almost every part of our body, from our skin to our nose, lungs and even internal organs.
    • In the meantime, natural killer cells, aptly named, attack infected cells, and stop viruses from multiplying and invading our body further.
    • At this stage, our immune system is fighting a war against viruses and the result can cause inflammation, fevers, coughs and congestion.

Launching a specific attack

    • As the innate immune response begins, another branch of the immune system called the adaptive immune system is activated.
    • The adaptive immune system is more specific than the innate immune system, and it decides on the correct tools and strategy to fight off the viral invaders.
    • B cells produce antibodies, which are proteins that can bind to viruses, neutralise them, and mark them for destruction by other immune cells.
    • B cells are a critical part of memory in our immune system.

Neutralising the threat

    • As the infection subsides, symptoms gradually improve, and we begin to feel better and to recover.
    • Some respiratory viruses, like rhinoviruses which cause the common cold, may cause relatively mild symptoms and a quick recovery.
    • Others, like the flu, SARS-CoV-2 or severe cases of RSV, may lead to more severe symptoms and a longer recovery time.

How burgers and chips for lunch can worsen your asthma that afternoon

Retrieved on: 
星期二, 七月 25, 2023

Food can affect how well your lungs function, how often you have asthma attacks and how well your puffer works.

Key Points: 
  • Food can affect how well your lungs function, how often you have asthma attacks and how well your puffer works.
  • Here’s what we know about which foods to eat more of, and which are best to eat in smaller amounts, if you have asthma.

Asthma and inflammation

    • This makes it difficult for them to breathe during what’s commonly known as an asthma attack (or exacerbation).
    • Researchers are becoming increasingly aware of how someone’s diet can affect their asthma symptoms, including how often they have one of these attacks.
    • Read more:
      Passive smoking, synthetic bedding and gas heating in homes show the strongest links to asthma

Thumbs up for fruit and veg

    • The Mediterranean diet – a diet high in fruit, vegetables and oily fish – is linked with less wheezing in children, whether or not they have been diagnosed with asthma.
    • Some, but not all, of the studies found this was regardless of the children’s body-mass index (BMI) or socioeconomic status.
    • However a review looked at five studies that investigated omega-3 intake (through the diet or with a supplement) in adults with asthma.
    • Of course there is no harm in eating foods high in omega-3 – such as oily fish, flaxseeds, chia seeds and walnuts.

Thumbs down for saturated fat, sugar, red meat

    • Diets high in saturated fats, plus sugar and red meat, can worsen someone’s asthma symptoms.
    • Foods high in saturated fat can have an impact in as little as four hours.
    • People who ate the meal high in saturated fat had reduced lung function within four hours.

What about dairy?


    One food type you don’t have to avoid, though, is dairy products. Although many people with asthma report eating dairy worsens their asthma, evidence shows this to be untrue. In fact, one study in adults with asthma found drinking milk was linked to better lung function.

    Read more:
    Monday's medical myth: dairy products exacerbate asthma

Feinstein Institutes Researchers Discover Defensive Molecules That Can Worsen Inflammation in Sepsis

Retrieved on: 
星期五, 七月 21, 2023

In a potential therapeutic breakthrough, investigators at The Feinstein Institutes for Medical Research have identified a type of white blood cell that can worsen inflammation in sepsis and opens up new avenues of research to treat the deadly condition.

Key Points: 
  • In a potential therapeutic breakthrough, investigators at The Feinstein Institutes for Medical Research have identified a type of white blood cell that can worsen inflammation in sepsis and opens up new avenues of research to treat the deadly condition.
  • (Credit: Feinstein Institutes)
    Results of the study, led by Ping Wang, MD , professor and chief scientific officer at the Feinstein Institutes, were published today in the Journal of Clinical Investigation .
  • “APANs, when triggered, can result in devastating circumstances for patients who have sepsis,” said Dr. Wang, senior author of the paper.
  • Last year, Dr. Wang and co-principal investigators at the Feinstein Institutes received $3.8 million from the National Institute of Health to study sepsis and radiation exposure.

LIfT BioSciences heralds a new era of affordable effective cancer cell therapies simply produced from iPSCs

Retrieved on: 
星期四, 七月 6, 2023

London, 6 July 2023 –LIfT BioSciences, (‘LifT’ or ‘the Company’), a rapidly emerging biotech company bringing to market a first-in-class allogeneic innate cell therapy, today announced successful proof-of-concept production of its patented cancer killing alpha neutrophils from induced pluripotent stem cells (iPSCs).

Key Points: 
  • London, 6 July 2023 –LIfT BioSciences, (‘LifT’ or ‘the Company’), a rapidly emerging biotech company bringing to market a first-in-class allogeneic innate cell therapy, today announced successful proof-of-concept production of its patented cancer killing alpha neutrophils from induced pluripotent stem cells (iPSCs).
  • Alex Blyth, Chief Executive Officer of LIfT BioSciences, commented: “Our goal is to develop a scalable and cost-effective off-the-shelf cell therapy that can be used in all cancer patients without the ongoing need for stem cell donors.
  • Our patented production process is pretty simple compared to other cell therapies, with no feeder cells or expensive magnetic bead enrichment being required.
  • It is therefore incredibly exciting that our IMANs, which we have designed to overcome many of the challenges with other cell therapies, can now also be made with an even lower cost of goods from iPSCs.

LIfT BioSciences heralds a new era of affordable effective cancer cell therapies simply produced from iPSCs

Retrieved on: 
星期四, 七月 6, 2023

London, 6 July 2023 –LIfT BioSciences, (‘LifT’ or ‘the Company’), a rapidly emerging biotech company bringing to market a first-in-class allogeneic innate cell therapy, today announced successful proof-of-concept production of its patented cancer killing alpha neutrophils from induced pluripotent stem cells (iPSCs).

Key Points: 
  • London, 6 July 2023 –LIfT BioSciences, (‘LifT’ or ‘the Company’), a rapidly emerging biotech company bringing to market a first-in-class allogeneic innate cell therapy, today announced successful proof-of-concept production of its patented cancer killing alpha neutrophils from induced pluripotent stem cells (iPSCs).
  • Alex Blyth, Chief Executive Officer of LIfT BioSciences, commented: “Our goal is to develop a scalable and cost-effective off-the-shelf cell therapy that can be used in all cancer patients without the ongoing need for stem cell donors.
  • Our patented production process is pretty simple compared to other cell therapies, with no feeder cells or expensive magnetic bead enrichment being required.
  • It is therefore incredibly exciting that our IMANs, which we have designed to overcome many of the challenges with other cell therapies, can now also be made with an even lower cost of goods from iPSCs.

First Patient Enrolled in SeaStar Medical’s Pivotal Clinical Trial with the Selective Cytopheretic Device in Adults with Acute Kidney Injury

Retrieved on: 
星期二, 六月 20, 2023

DENVER, June 20, 2023 (GLOBE NEWSWIRE) -- SeaStar Medical Holding Corporation (Nasdaq: ICU), a medical device company developing proprietary solutions to reduce the consequences of hyperinflammation on vital organs, announces enrollment of the first patient in the NEUTRALIZE-AKI pivotal clinical trial to evaluate the safety and efficacy of its patented, first-in-class, cell-directed Selective Cytopheretic Device (SCD) extracorporeal therapy in critically ill adults with acute kidney injury (AKI) requiring continuous kidney replacement therapy (CKRT).

Key Points: 
  • DENVER, June 20, 2023 (GLOBE NEWSWIRE) -- SeaStar Medical Holding Corporation (Nasdaq: ICU), a medical device company developing proprietary solutions to reduce the consequences of hyperinflammation on vital organs, announces enrollment of the first patient in the NEUTRALIZE-AKI pivotal clinical trial to evaluate the safety and efficacy of its patented, first-in-class, cell-directed Selective Cytopheretic Device (SCD) extracorporeal therapy in critically ill adults with acute kidney injury (AKI) requiring continuous kidney replacement therapy (CKRT).
  • “We are delighted to enroll the first patient into our pivotal trial following the successful resolution of a supply-chain issue that temporarily impacted the sourcing of tubing connectors that are part of the SCD sets,” said Kevin Chung, MD, Chief Medical Officer of SeaStar Medical.
  • “Nearly two dozen hospitals and academic centers have signed on to begin the process of onboarding as clinical trial sites.
  • These sites are at various stages of activation with several anticipated to begin enrollment very soon.”
    “We believe that reprogramming activated neutrophils and monocytes represents a major breakthrough for managing hyperinflammation in acute illness.

OSE Immunotherapeutics Presents Update on BiCKI®IL-7, CLEC-1 and OSE-230 Preclinical Programs in Immuno-Oncology and Immuno-Inflammation At International Conferences

Retrieved on: 
星期四, 六月 15, 2023

Dr Nicolas Poirier, Chief Executive Officer of OSE Immunotherapeutics, commented: “We are very proud to share our latest scientific advances on our innovative pre-IND research programs with the international scientific community.

Key Points: 
  • Dr Nicolas Poirier, Chief Executive Officer of OSE Immunotherapeutics, commented: “We are very proud to share our latest scientific advances on our innovative pre-IND research programs with the international scientific community.
  • We are looking forward to progressing these programs with strategic partners into clinical stage”.
  • Dr Aurore Morello, Head of Research of OSE Immunotherapeutics, said: “The latest data featured in our communications highlight the value and therapeutic potential of our pre-IND assets.
  • BiCKI®-IL-7, our bispecific anti-PD1/IL-7 program, presents an innovative cytokine approach, selectively targeting tumor-specific T-cells to improve the quality and durability of memory T-lymphocyte responses.

5G Open Innovation Lab Teams with F5, GXC, and Spirent Communications to Lay the Groundwork for Faster Deployment of Private Mobile Networks

Retrieved on: 
星期三, 五月 31, 2023

As 5G infrastructure becomes more mainstream, enterprises and organizations are subsequently deploying more private networks and telco clouds into strategic locations to leverage newly available connectivity, lower latency, and agility.

Key Points: 
  • As 5G infrastructure becomes more mainstream, enterprises and organizations are subsequently deploying more private networks and telco clouds into strategic locations to leverage newly available connectivity, lower latency, and agility.
  • F5, a hybrid and multi-cloud application services and security company, deployed carrier-grade BIG-IP Virtual Editions .
  • These security functions were consolidated with an N6/SGi-LAN solution adding another layer of speed and security at the network level.
  • Finally, the entire solution was pressure-tested through technology made available through the 5G OI Lab and its enterprise and operator partners deployed with GXC’s ONYX Portal.

Revolo Biotherapeutics Presents New Preclinical Data for ‘1104 in Acute Respiratory Distress Syndrome Associated With Influenza Infection at the ATS 2023 International Conference

Retrieved on: 
星期一, 五月 22, 2023

NEW ORLEANS and CAMBRIDGE, UK,, May 22, 2023 (GLOBE NEWSWIRE) -- Revolo Biotherapeutics (“Revolo” or the “Company”), a company developing therapies that reset the immune system to achieve superior long-term remission for patients with autoimmune and allergic diseases, today announced new preclinical data discussed in a poster presentation at the American Thoracic Society (ATS) 2023 International Conference. The poster showcases the ability of its immune-resetting drug candidate ‘1104 to inhibit and reduce lung inflammation without immunosuppression in a new model of acute respiratory distress syndrome (ARDS) associated with influenza infection.

Key Points: 
  • The poster showcases the ability of its immune-resetting drug candidate ‘1104 to inhibit and reduce lung inflammation without immunosuppression in a new model of acute respiratory distress syndrome (ARDS) associated with influenza infection.
  • “The data continues to highlight the unique mechanism of action (MOA) of ‘1104, acting ahead of the inflammatory cascade to reset the immune system.
  • Three days after infection, animals received either PBS (negative control) or 30µg of polyinosinic-polycytidylic acid (poly I:C) to exacerbate influenza-induced lung inflammation.
  • At 48 hours after the poly I:C challenge, bronchoalveolar lavage fluid was collected to conduct differential cell counts and to measure cytokines.