Mineral

Draft guideline on good agricultural and collection practice (GACP) for starting materials of herbal origin - Revision 1

Retrieved on: 
星期四, 四月 18, 2024

REFERENCES ....................................................................................................................................... 14

Key Points: 
    • REFERENCES ....................................................................................................................................... 14

      29

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 3/14

      30

      EXECUTIVE SUMMARY

      31
      32
      33
      34
      35
      36

      This guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin

      37

      1.

    • Due to the inherent
      complexity of medicinal plants and herbal substances the quality of these starting materials requires an
      adequate quality assurance system for the collection and/or cultivation, harvest, and primary
      processing.
    • (either outdoor, indoor or in greenhouses) should be carefully considered, since each of the mentioned
      types could have several problems and advantages.
    • The used cultivation method may be dependent on
      the final application of the herbal medicinal product.
    • primary processing of herbal substances that are used for the preparation of herbal medicinal products.
    • medicinal plants and herbal substances, ensuring that they are handled appropriately throughout all
      stages of cultivation, collection, processing and storage.
    • their preparations are exposed to a large number of environmental contaminants of both biotic and
      abiotic origin.
    • to existing wildlife habitats and must adhere to CITES (Convention on International Trade in
      Endangered species of Wild Fauna and Flora).
    • https://health.ec.europa.eu/document/download/bd537ccf-9271-4230-bca1-2d...
      4 https://health.ec.europa.eu/document/download/fd318dd6-2404-4e67-82b0232...
      3

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 5/14

      104

      4.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

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      147
      148
      149

      8.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 7/14

      185

      7.

    • Where possible, stable varieties and cultivars naturally
      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 8/14

      227
      228

      resistant or tolerant to disease should preferably be used.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 9/14

      268
      269
      270
      271
      272
      273

      The application should be carried out only by qualified staff using approved equipment.

    • The following should be noted:

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 10/14

      309
      310

      ?

      311
      312
      313

      ?

      314
      315
      316
      317

      ?

      318
      319
      320

      ?

      321
      322

      ?

      323
      324
      325

      ?

      326
      327
      328

      ?

      Damaged plants or plant parts need to be excluded or limited in accordance with a specific
      pharmacopoeia monograph, where relevant.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 11/14

      347
      348

      directly to the sun (except in cases where there is a specific need) and must be protected from
      rainfall, insect infestation, etc.

    • The label must be clear, permanently fixed and made from

      6

      Reflection paper on the use of fumigants (EMEA/HMPC/125562/2006)

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 12/14

      386
      387

      non-toxic material.

    • Certain exudates that have not been subjected to a specific treatment are

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 13/14

      425
      426
      427

      also considered to be herbal substances.

    • European Pharmacopoeia General Monograph ?HERBAL DRUGS? 07/2017:1433

      Are obtained by subjecting herbal substances to treatments such as
      extraction, distillation, expression, fractionation, purification, concentration
      or fermentation.

Draft guideline on good agricultural and collection practice (GACP) for starting materials of herbal origin - Revision 1

Retrieved on: 
星期四, 四月 18, 2024

REFERENCES ....................................................................................................................................... 14

Key Points: 
    • REFERENCES ....................................................................................................................................... 14

      29

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 3/14

      30

      EXECUTIVE SUMMARY

      31
      32
      33
      34
      35
      36

      This guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin

      37

      1.

    • Due to the inherent
      complexity of medicinal plants and herbal substances the quality of these starting materials requires an
      adequate quality assurance system for the collection and/or cultivation, harvest, and primary
      processing.
    • (either outdoor, indoor or in greenhouses) should be carefully considered, since each of the mentioned
      types could have several problems and advantages.
    • The used cultivation method may be dependent on
      the final application of the herbal medicinal product.
    • primary processing of herbal substances that are used for the preparation of herbal medicinal products.
    • medicinal plants and herbal substances, ensuring that they are handled appropriately throughout all
      stages of cultivation, collection, processing and storage.
    • their preparations are exposed to a large number of environmental contaminants of both biotic and
      abiotic origin.
    • to existing wildlife habitats and must adhere to CITES (Convention on International Trade in
      Endangered species of Wild Fauna and Flora).
    • https://health.ec.europa.eu/document/download/bd537ccf-9271-4230-bca1-2d...
      4 https://health.ec.europa.eu/document/download/fd318dd6-2404-4e67-82b0232...
      3

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 5/14

      104

      4.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 6/14

      147
      148
      149

      8.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 7/14

      185

      7.

    • Where possible, stable varieties and cultivars naturally
      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 8/14

      227
      228

      resistant or tolerant to disease should preferably be used.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 9/14

      268
      269
      270
      271
      272
      273

      The application should be carried out only by qualified staff using approved equipment.

    • The following should be noted:

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 10/14

      309
      310

      ?

      311
      312
      313

      ?

      314
      315
      316
      317

      ?

      318
      319
      320

      ?

      321
      322

      ?

      323
      324
      325

      ?

      326
      327
      328

      ?

      Damaged plants or plant parts need to be excluded or limited in accordance with a specific
      pharmacopoeia monograph, where relevant.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 11/14

      347
      348

      directly to the sun (except in cases where there is a specific need) and must be protected from
      rainfall, insect infestation, etc.

    • The label must be clear, permanently fixed and made from

      6

      Reflection paper on the use of fumigants (EMEA/HMPC/125562/2006)

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 12/14

      386
      387

      non-toxic material.

    • Certain exudates that have not been subjected to a specific treatment are

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 13/14

      425
      426
      427

      also considered to be herbal substances.

    • European Pharmacopoeia General Monograph ?HERBAL DRUGS? 07/2017:1433

      Are obtained by subjecting herbal substances to treatments such as
      extraction, distillation, expression, fractionation, purification, concentration
      or fermentation.

Fossil beetles found in a Botswana diamond mine help us to reconstruct the distant past

Retrieved on: 
星期三, 四月 10, 2024

One of the few Cretaceous age deposits that’s been discovered in Africa is at Botswana’s Orapa Diamond Mine.

Key Points: 
  • One of the few Cretaceous age deposits that’s been discovered in Africa is at Botswana’s Orapa Diamond Mine.
  • Recently a team I lead discovered two new species of rove beetles preserved in the sediments of the Orapa Diamond Mine.
  • Rove beetles are typically identified by their unique short elytra (protective wing cases) which expose the rest of the abdomen.
  • Our finds are the first fossil rove beetles ever discovered on the continent and in the southern hemisphere.
  • The fossils closely resemble today’s rove beetles, showing how successful they’ve been in adapting to various environments without significant changes to their bodies.

Identifying the fossils

  • We found the fossils in lacustrine sediments (deposits that accumulate in lake environments).
  • Afristenus orapensis belongs to the stenine rove beetle subgroup while Paleothius mckayi belongs to the subgroup staphylinine.
  • The stenine rove beetle was previously described in Russia, France and Myanmar while the staphylinine rove beetle was previously described in Russia, China, Myanmar and England.
  • So we scoured research articles about fossils of a similar age that have already been studied elsewhere for comparative purposes.

More to find

  • We are currently studying each specimen and preparing academic manuscripts that describe what we’ve found.
  • My hope is that more money will be invested in training more palaeoentomologists in South Africa and on the continent more broadly.
  • The study of fossil insects and plants is an important way to preserve our beloved continent’s heritage.


Sandiso Mnguni receives funding from GENUS (Centre of Excellence in Palaeosciences - UID 86073). He is affiliated with the Sophumelela Youth Development Programme (SYDP).

Bedrock conditions in Finnish mine project ideal

Retrieved on: 
星期三, 四月 10, 2024

Stockholm, 18 March 2024 – The mining company Eurobattery Minerals AB (Nordic Growth Market: “ BAT ” and Börse Stuttgart: “ EBM ”; in short: “EBM”, “Eurobattery” or “the Company”) today announced positive results on research proving that the bedrock conditions in its Finnish Hautalampi battery minerals mine project are ideal for future mining operations.

Key Points: 
  • Stockholm, 18 March 2024 – The mining company Eurobattery Minerals AB (Nordic Growth Market: “ BAT ” and Börse Stuttgart: “ EBM ”; in short: “EBM”, “Eurobattery” or “the Company”) today announced positive results on research proving that the bedrock conditions in its Finnish Hautalampi battery minerals mine project are ideal for future mining operations.
  • With the analysis ready, it can be concluded that the shear zones follow the geology of the bedrock, and no larger dominant shear zones were found, i.e., the bedrock conditions in Hautalampi are favorable for mining operations.
  • “As the Hautalampi project is located on an old mining ground, we knew already that the geology was suitable for further mining.
  • Yet, the results from the geophysical tests further cement that our Hautalampi battery minerals mine project has all the preconditions to be an important source of responsibly mined battery minerals.

Accelerating forward Thailand’s cement roadmap, Dr. Chana Poomee, TCMA Chairman, is set to strengthen tie with global green funds boosting Thai industry competitiveness and effort to achieve the Net Zero 2050

Retrieved on: 
星期三, 四月 10, 2024

Dr. Chana Poomee, along with the TCMA Board, outlined the long-term direction of TCMA, which is a collaboration nexus of leading Thai cement producers.

Key Points: 
  • Dr. Chana Poomee, along with the TCMA Board, outlined the long-term direction of TCMA, which is a collaboration nexus of leading Thai cement producers.
  • TCMA, over the next two years, 2024-2026 will accelerate its efforts to join forces with all sectors to achieve the key missions in four areas:
    1.
  • Accelerating the expansion of maximize resource-efficiency mining practices according to the Minerals Act B.E.
  • TCMA, with this action aims to reduce greenhouse gas emissions not less than 6.9 million tons of carbon dioxide in 2030.

EQS-News: Epanko Project Flyover

Retrieved on: 
星期三, 四月 10, 2024

The Company confirms that it is not aware of any new information or data that materially affects the information included in the relevant market announcement.

Key Points: 
  • The Company confirms that it is not aware of any new information or data that materially affects the information included in the relevant market announcement.
  • The information in this report that relates to Mineral Resources is based on, and fairly reflects, information compiled by Mr. David Williams and Mr. David Drabble.
  • Mr. David Williams is a full-time employee of ERM and is a Member of the Australian Institute of Geoscientists (#4176)(RPGeo).
  • Mr. David Drabble is a full-time employee of EcoGraf Ltd and is a Member of the Australasian Institute of Mining and Metallurgy (#307348).

EQS-News: EcoGraf: Product Qualification Facility Commissioning Commenced

Retrieved on: 
星期三, 四月 10, 2024

EcoGraf Limited (EcoGraf or the Company) (ASX: EGR; FSE: FMK; OTCQX: ECGFF) is pleased to announce an update on construction and commissioning activities for the Product Qualification Facility (‘PQF’ or ‘Facility’) in Western Australia with operations to commence in April 2024.

Key Points: 
  • EcoGraf Limited (EcoGraf or the Company) (ASX: EGR; FSE: FMK; OTCQX: ECGFF) is pleased to announce an update on construction and commissioning activities for the Product Qualification Facility (‘PQF’ or ‘Facility’) in Western Australia with operations to commence in April 2024.
  • The PQF will undertake a number of product campaigns which is scheduled over the remainder of the year, the plant will operate at 5-10kg/hr with the first 5 tonnes of product in place for processing.
  • The Facility will complement the Company’s product testing activities, while the PQF campaigns will benefit from recent flowsheet improvements that is expected to support further reduction in costs while increasing the purity of the material above customers specifications.
  • The Facility is jointly funded through the Commonwealth Government’s A$48.9m Critical Minerals Development Program, which is supporting Australian battery minerals processing capability.

Atlas Lithium Secures US$ 30,000,000 Strategic Investment and Offtake Agreement from Mitsui

Retrieved on: 
星期四, 三月 28, 2024

The Strategic Investment provides Atlas Lithium with immediately available funds to continue its rapid development towards revenue generation with the production and sale of high-quality, low cost, environmentally sustainable lithium concentrate.

Key Points: 
  • The Strategic Investment provides Atlas Lithium with immediately available funds to continue its rapid development towards revenue generation with the production and sale of high-quality, low cost, environmentally sustainable lithium concentrate.
  • The Strategic Investment is a culmination of the mutual interest in growing Atlas Lithium.
  • Mitsui's investment reflects confidence in our team, assets, and business model," stated Marc Fogassa, CEO and Chairman of Atlas Lithium.
  • I have watched the relationship of our companies grow and I believe that this partnership with Mitsui strengthens Atlas Lithium substantially."

Canter Resources Selects Cascade for Shallow Geoprobe Drilling at Columbus

Retrieved on: 
星期三, 三月 27, 2024

Vancouver, British Columbia--(Newsfile Corp. - March 27, 2024) - Canter Resources Corp. (CSE: CRC) (OTC Pink: CNRCF) (FSE: 6O1) ("Canter" or the "Company") is pleased to report that the Company has selected Cascade Drilling L.P. to complete shallow Geoprobe drilling at the Columbus Lithium-Boron Project ("Columbus" or the "Project"), located near Tonopah, Nevada.

Key Points: 
  • Vancouver, British Columbia--(Newsfile Corp. - March 27, 2024) - Canter Resources Corp. (CSE: CRC) (OTC Pink: CNRCF) (FSE: 6O1) ("Canter" or the "Company") is pleased to report that the Company has selected Cascade Drilling L.P. to complete shallow Geoprobe drilling at the Columbus Lithium-Boron Project ("Columbus" or the "Project"), located near Tonopah, Nevada.
  • The Geoprobe drill campaign has been designed to collect both sediment and water samples from depths ranging between 3-30 metres (approximately 10-100 feet) below surface.
  • "The shallow Geoprobe program compliments our upcoming exploration well drilling as part of Phase I work and will provide us with another valuable dataset at Columbus," stated Joness Lang, CEO of Canter Resources.
  • In addition to characterizing the interpreted shallow brine generation layer, the Geoprobe drilling will provide more structural and geochemical data from 15-45 m depths that will further inform the Company's geological model.

Calibre’s Q1 Gold Production on Track to Deliver Full Year 2024 Guidance While Advancing Operational Readiness For H1, 2025 First Gold at The Fully Funded Valentine Gold Mine

Retrieved on: 
星期二, 四月 9, 2024

We remain on track to deliver full year 2024 production guidance of 275,000 – 300,000 ounces.

Key Points: 
  • We remain on track to deliver full year 2024 production guidance of 275,000 – 300,000 ounces.
  • Since becoming a gold producer during Q4, 2019, Calibre has delivered annual production growth of 28% year on year, with a track record of meeting or beating expectations.
  • 2024 and 2025 will be transformational years, driven by an increase in gold production and significant exploration across the Americas.
  • I am pleased to report the final phases of construction and operational readiness remain on track and fully funded at VGM in preparation for first gold production in H1, 2025 to unlock significant production growth and value for our shareholders.