Insulin

• But type “setting a weight loss goal” into any online search engine and you’ll likely be left with more questions than answers.
• They’ll typically use a body mass index (BMI) calculator to confirm a “healthy” weight and provide a goal weight based on this range.
• Most sales pitches will suggest you need to lose substantial amounts of weight to be healthy – making weight loss seem an impossible task.

Using BMI to define our target weight is flawed

• So it’s no surprise we use measurements and equations to score our weight.
• BMI classifies bodies as underweight, normal (healthy) weight, overweight or obese and can be a useful tool for weight and health screening.

fails to consider two critical factors related to body weight and health – body fat percentage and distribution
does not account for significant differences in body composition based on gender, ethnicity and age.

How does losing weight benefit our health?

• Losing just 5–10% of our body weight – between 6 and 12kg for someone weighing 120kg – can significantly improve our health in four key ways.
• But research shows improvements in total cholesterol, LDL cholesterol and triglyceride levels are evident with just 5% weight loss.
• Excess weight is linked to high blood pressure in several ways, including changing how our sympathetic nervous system, blood vessels and hormones regulate our blood pressure.

• A meta-analysis of 25 trials on the influence of weight reduction on blood pressure also found every kilo of weight loss improved blood pressure by one point.
• Research shows just 7% weight loss reduces risk of developing type 2 diabetes by 58%.
• In one study each kilogram of weight loss resulted in a fourfold decrease in the load exerted on the knee in each step taken during daily activities.

Focus on long-term habits

• An analysis of 29 long-term weight-loss studies found participants regained more than half of the weight lost within two years.
• When we lose weight, we take our body out of its comfort zone and trigger its survival response.
• Read more:
  What's the 'weight set point', and why does it make it so hard to keep weight off?

losing weight in small manageable chunks you can sustain, specifically periods of weight loss, followed by periods of weight maintenance, and so on, until you achieve your goal weight
making gradual changes to your lifestyle to ensure you form habits that last a lifetime.
Setting a goal to reach a healthy weight can feel daunting. But it doesn’t have to be a pre-defined weight according to a “healthy” BMI range. Losing 5–10% of our body weight will result in immediate health benefits. At the Boden Group, Charles Perkins Centre, we are studying the science of obesity and running clinical trials for weight loss. You can register here to express your interest.
Dr Nick Fuller works for the University of Sydney and has received external funding for projects relating to the treatment of overweight and obesity. He is the author and founder of the Interval Weight Loss program.

• Addison, TX, Jan. 31, 2024 (GLOBE NEWSWIRE) -- MDB Capital Holdings, LLC, (NASDAQ: MDBH) (“MDB”), a public venture platform with the objective of growing the public venture marketplace and optimizing the way meaningful technologies are financed and built, today released its annual letter to shareholders from its CEO and Co-Founder, Christopher Marlett.
• To the Shareholders of MDB Capital Holdings, LLC:
  Welcome to our first annual letter, which I plan to send every January to reflect on the past year and how what we learned will shape our plans for the following year.
• Undervalued Public Companies: We identify and partner with more mature public companies with undervalued technologies that possess significant leadership potential.
• We then combine that with our community of experienced investors that commit not only their monetary capital, but their intellectual capital to help each company succeed.

• The study showed that, for older adults with overweight or obesity, longer-term consumption of mixed nuts significantly improved brain insulin sensitivity.
• Cerebral blood flow (CBF) was quantified using magnetic resonance imaging (MRI), while brain insulin sensitivity was assessed by measuring regional CBF responses to intranasal insulin.
• The study found that nut consumption significantly improved insulin action in (occipital and frontal) brain regions involved in the modulation of metabolic and cognitive processes.
• However, intrahepatic lipid content, serum LDL ("bad") cholesterol and systolic blood pressure were lower following nut consumption compared to the control period.

• In December 2023, we completed an in-licensing of a new, potentially disease modifying, orally delivered clinical stage molecule for Type I diabetes, an unmet medical disease.
• Tolimidone is an activator of lyn kinase which has been shown to play a significant role in cell proliferation, differentiation, apoptosis, migration and metabolism.
• We expect to report data from the in vivo LMD efficacy model by the end of the first quarter of 2024.
• Certain statements in this shareholder letter may constitute “forward-looking statements” within the meaning of legislation in the United Kingdom and/or United States.