Danio

INDIGO's Preclinical Animal Model Platform Expands Zebrafish Offering

Retrieved on: 
Tuesday, October 6, 2020
Biology, Branches of biology, Animal testing, Regenerative biomedicine, Organisms, Danio, Stem cell research, Zebrafish, Nuclear receptor, Animal disease model

STATE COLLEGE, Pa., Oct. 6, 2020 /PRNewswire-PRWeb/ --INDIGO Biosciences, the recognized industry leader in nuclear receptor research, has expanded their robust portfolio of in vitro animal model assays with three additional first-in-class zebrafish model systems.

Key Points: 
  • STATE COLLEGE, Pa., Oct. 6, 2020 /PRNewswire-PRWeb/ --INDIGO Biosciences, the recognized industry leader in nuclear receptor research, has expanded their robust portfolio of in vitro animal model assays with three additional first-in-class zebrafish model systems.
  • "This addition gives discovery scientists the ability to make key determinations on the correct animal model for their research with an ortholog that was not previously available before entering animal trials."
  • For researchers looking at nuclear receptor activity, zebrafish provide an attractive model as nearly all of the 48 human nuclear receptors are also present in the animal model.
  • With animal studies required by the FDA, selecting the animal model that provides the most representative human-surrogate is critical to assessing a potential drug's likelihood of unwanted effects.

"White Mouse in Water" - Infinitus Develops New Technology of Using Zebrafish for Health Products Screening

Retrieved on: 
Tuesday, July 28, 2020
Organisms, Danio, Regenerative biomedicine, Stem cell research, Zebrafish, Branches of biology, Animals

"Using the zebrafish safety assessment methods, we established a zebrafish safety assessment database containing 112 food ingredients and safety data for 44 products, as well as technical methods for formula screening, product optimization and quality control," said Liu.

Key Points: 
  • "Using the zebrafish safety assessment methods, we established a zebrafish safety assessment database containing 112 food ingredients and safety data for 44 products, as well as technical methods for formula screening, product optimization and quality control," said Liu.
  • Zebrafish are highly similar to mammals in physiology, development and metabolism, and share an 87% homology with human genes.
  • The approach has been regarded as highly innovative in the field of health food in China.
  • As early as 2003, National Institutes of Health (NIH) in US listed zebrafish as important experimental creatures, after rats and mice.

PolyU discovers the effect of chemical compound PTU on autophagy in zebrafish embryos, sheds light on cancer medication research

Retrieved on: 
Friday, July 10, 2020
Branches of biology, Biology, Organisms, Danio, Regenerative biomedicine, Stem cell research, Zebrafish, Programmed cell death, Autophagy

Fast development, cost-effective and easy to breed are also primary drivers for using the zebrafish research model.

Key Points: 
  • Fast development, cost-effective and easy to breed are also primary drivers for using the zebrafish research model.
  • This ground-breaking finding subsequently sheds light on the respective research guidelines and the research protocol in on-going studies on autophagy and haematology, warranting researchers to re-examine research that is linked to existing cancer therapy options.
  • The research titled "1-phenyl 2-thiourea (PTU) Activates Autophagy in Zebrafish Embryos" ( link ) was published in Autophagy, a peer-reviewed science journal in April 2020.
  • In most research using the zebrafish model, a chemical compound called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging.

PolyU discovers the effect of chemical compound PTU on autophagy in zebrafish embryos, sheds light on cancer medication research

Retrieved on: 
Friday, July 10, 2020
Branches of biology, Biology, Organisms, Danio, Regenerative biomedicine, Stem cell research, Zebrafish, Programmed cell death, Autophagy

Fast development, cost-effective and easy to breed are also primary drivers for using the zebrafish research model.

Key Points: 
  • Fast development, cost-effective and easy to breed are also primary drivers for using the zebrafish research model.
  • This ground-breaking finding subsequently sheds light on the respective research guidelines and the research protocol in on-going studies on autophagy and haematology, warranting researchers to re-examine research that is linked to existing cancer therapy options.
  • The research titled "1-phenyl 2-thiourea (PTU) Activates Autophagy in Zebrafish Embryos" ( link ) was published in Autophagy, a peer-reviewed science journal in April 2020.
  • In most research using the zebrafish model, a chemical compound called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging.

PolyU discovers the effect of chemical compound PTU on autophagy in zebrafish embryos, sheds light on cancer medication research

Retrieved on: 
Thursday, July 9, 2020
Branches of biology, Biology, Organisms, Danio, Regenerative biomedicine, Stem cell research, Zebrafish, Autophagy

HONG KONG, July 9, 2020 /PRNewswire-PRWeb/ --In most research using the zebrafish model, a chemical compound called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging.

Key Points: 
  • HONG KONG, July 9, 2020 /PRNewswire-PRWeb/ --In most research using the zebrafish model, a chemical compound called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging.
  • The research finding means that when we are using this prominent model to study any autophagy-related processes like cancer, the results may not be truly reflected.
  • Dr MA added that the team has already suspended the use of PTU in zebrafish research.
  • Dr MA has also been invited as co-author for new guidelines on autophagy research using zebrafish embryos, a revision that takes place every four years.

HKBU Study: Sunscreen Chemicals Harm Fish Embryos and Could Pose Risk to Humans

Retrieved on: 
Thursday, October 4, 2018
Danio, Regenerative biomedicine, Stem cell research, Zebrafish, Pollution, Hong Kong Baptist University, Biology, Fish

A study by Hong Kong Baptist University (HKBU) has detected an extensive amount of sunscreen chemicals in seawater that could pose a risk to human health.

Key Points: 
  • A study by Hong Kong Baptist University (HKBU) has detected an extensive amount of sunscreen chemicals in seawater that could pose a risk to human health.
  • The study, a world-first in identifying the harm caused by a combination of polluting chemicals in sunscreen, found the chemicals can cause abnormalities in and kill the offspring of zebrafish by entering the food chain.
  • As the genetic structure of zebrafish resembles that of humans, the results imply that these contaminants could pose a risk to humans.
  • The team was led by Dr Kelvin Leung Sze-yin, Associate Professor of the Department of Chemistry of HKBU.