Hypnotics

Lemborexant Respiratory Safety Data Presented at SLEEP 2019

Retrieved on: 
Tuesday, June 11, 2019
Chemical compounds, Branches of biology, Sleep disorders, Animal physiology, Hypnotics, Cyclopropanes, Lemborexant, Pyridines, Pyrimidines, Sleep apnea, Obstructive sleep apnea, Apnea

WOODCLIFF LAKE, N.J., June 11, 2019 /PRNewswire/ --Eisai Inc. today announced data on the respiratory safety of investigational lemborexant with multiple and single dosing in healthy adult and elderly individuals, as well as in those with mild obstructive sleep apnea (OSA).

Key Points: 
  • WOODCLIFF LAKE, N.J., June 11, 2019 /PRNewswire/ --Eisai Inc. today announced data on the respiratory safety of investigational lemborexant with multiple and single dosing in healthy adult and elderly individuals, as well as in those with mild obstructive sleep apnea (OSA).
  • These studies were presented at the 33rd annual meeting of the Associated Professional Sleep Societies (SLEEP 2019) in San Antonio.
  • Key respiratory safety data presented at SLEEP 2019 are from Study 102, a two-part study on the respiratory safety of lemborexant.
  • The incidence of TEAEs reported was 6.3% with lemborexant 10 mg, 23.5% with lemborexant 25 mg and 6.3% with placebo.

Extensive Analyses of Phase 3 Data for Investigational Lemborexant Assess Efficacy and Safety Profile for the Potential Treatment of Insomnia in Adults

Retrieved on: 
Tuesday, June 11, 2019
Chemical compounds, Hypnotics, Organofluorides, Cyclopropanes, Lemborexant, Pyridines, Pyrimidines

These analyses of lemborexant assessed its efficacy on key insomnia measures, improvement in patient daytime function and long-term safety.

Key Points: 
  • These analyses of lemborexant assessed its efficacy on key insomnia measures, improvement in patient daytime function and long-term safety.
  • Earlier this year, the U.S. Food and Drug Administration accepted for review the New Drug Application for lemborexant for the treatment of insomnia.
  • Serious TEAEs were observed in a small proportion of patients (2.2% with lemborexant 5 mg, 2.9% with lemborexant 10 mg, 1.6% with placebo).
  • Efficacy analyses included 402 (23.7%) male and 1,291 (76.3%) female patients, and safety analyses included 404 (25.0%) male and 1,286 (75.0%) female patients.

Eisai to Present Eight Lemborexant Posters at SLEEP 2019 Meeting, Including New Pooled Analyses From Phase 3 Studies and New Phase 1 Data

Retrieved on: 
Tuesday, May 28, 2019
Chemical compounds, Psychoactive drugs, Hypnotics, Cyclopropanes, Lemborexant, Organofluorides, Pyridines, Pyrimidines, Insomnia, Eisai, Sleep disorder

Separate from the poster presentations, Eisai will host a symposium entitled An Interactive Case-Based Dialogue on Insomnia Diagnostic and Therapeutic Decision Making.

Key Points: 
  • Separate from the poster presentations, Eisai will host a symposium entitled An Interactive Case-Based Dialogue on Insomnia Diagnostic and Therapeutic Decision Making.
  • Earlier this year, the U.S. Food and Drug Administration accepted for review the New Drug Application for lemborexant for the treatment of insomnia.
  • This release discusses investigational uses of an agent in development and is not intended to convey conclusions about efficacy or safety.
  • Eisai is investigating lemborexant as a potential treatment option for multiple sleep-wake disorders, such as insomnia.

NIAAA Recommends That Parents Talk With Their High School Grads About Celebrating Safely

Retrieved on: 
Wednesday, May 15, 2019
Psychoactive drugs, Neurochemistry, Drinking culture, Alcohol abuse, RTT, Hypnotics, Sedatives, Alcohol intoxication, Alcohol, Alcoholism

But before your high school seniors begin their parties, take the time to talk with them about keeping events alcohol-freeit just may save a life.

Key Points: 
  • But before your high school seniors begin their parties, take the time to talk with them about keeping events alcohol-freeit just may save a life.
  • And we know that any underage drinking can lead to consuming too much alcohol, which may result in poor decisions, injuries, alcohol overdose, and possibly death.
  • A teenager's brain is still developing, and it is very sensitive to alcohol's effects on judgment and decision-making.
  • It is critical to talk with your graduate because research shows that parents do make a difference.

NIAAA Recommends That Parents Talk With Their High School Grads About Celebrating Safely

Retrieved on: 
Monday, May 13, 2019
Psychoactive drugs, Neurochemistry, Drinking culture, Alcohol abuse, RTT, Hypnotics, Sedatives, Alcohol intoxication, Alcohol, Alcoholism

But before your high school seniors begin their parties, take the time to talk with them about keeping events alcohol-freeit just may save a life.

Key Points: 
  • But before your high school seniors begin their parties, take the time to talk with them about keeping events alcohol-freeit just may save a life.
  • And we know that any underage drinking can lead to consuming too much alcohol, which may result in poor decisions, injuries, alcohol overdose, and possibly death.
  • A teenager's brain is still developing, and it is very sensitive to alcohol's effects on judgment and decision-making.
  • It is critical to talk with your graduate because research shows that parents do make a difference.

Anti-depressant Prescriptions Associated with Increased Total Workers' Compensation Claims Cost, Delayed Return to Work

Retrieved on: 
Monday, April 22, 2019
Psychoactive drugs, Neurochemistry, GABAA receptor positive allosteric modulators, RTT, Benzodiazepine, Hypnotics, Sedatives, Opioid, Depressant, Antidepressant, Benzodiazepine overdose, Draft:Common practices in pain management

Previous studies involving the workers' compensation system have demonstrated a relationship between opioid medication prescription and escalating medical costs as well as increased claim duration.

Key Points: 
  • Previous studies involving the workers' compensation system have demonstrated a relationship between opioid medication prescription and escalating medical costs as well as increased claim duration.
  • This analysis evaluated the impact of benzodiazepines and antidepressants in combination with opioids on workers' compensation claim cost and closure rates.
  • "What did surprise us is the increased recovery time and medical costs associated with anti-depressant medications."
  • The effect on total paid costs associated with antidepressant prescription was greater in magnitude compared to all other drug classes.

Seroquel - Drug Insight, 2019-2021 - ResearchAndMarkets.com

Retrieved on: 
Friday, March 8, 2019
Health, Mental health, Pharmaceutical, Psychoactive drugs, Hypnotics, Piperazines, Quetiapine, Sedatives

The "Seroquel- Drug Insight, 2019" report has been added to ResearchAndMarkets.com's offering.

Key Points: 
  • The "Seroquel- Drug Insight, 2019" report has been added to ResearchAndMarkets.com's offering.
  • Seroquel Drug Insight, 2019 highlights the drug marketed details and the Global API Manufacturers details across the globe along with the location.
  • The report also covers the patents information and market exclusivity data, route of synthesis, market competition, and API manufacturers by country.
  • In addition to this, the report also provides the SWOT analysis for Seroquel and emerging therapies in this space.

Stilnox - Drug Insight, 2019 - ResearchAndMarkets.com

Retrieved on: 
Friday, February 1, 2019
Health, Pharmaceutical, Business intelligence, Strategic management, Hypnotics, Nonbenzodiazepines, RTT, Zolpidem, SWOT analysis

The "Stilnox - Drug Insight, 2019" report has been added to ResearchAndMarkets.com's offering.

Key Points: 
  • The "Stilnox - Drug Insight, 2019" report has been added to ResearchAndMarkets.com's offering.
  • Stilnox Drug Insight, 2019 highlights the drug marketed details and the Global API Manufacturers details across the globe along with the location.
  • The report also covers the patents information and market exclusivity data, route of synthesis, market competition, and API manufacturers by country.
  • In addition to this, the report also provides the SWOT analysis for Stilnox and emerging therapies in this space.

New Drug Application for Insomnia Disorder Treatment Lemborexant Submitted in the United States

Retrieved on: 
Tuesday, January 15, 2019
Hypnotics, Chemistry, Organic chemistry, Organofluorides, Neurochemistry, RTT, GABAA receptor positive allosteric modulators, Pyrimidines, Lemborexant, Zolpidem, SB-649868

In addition to the treatment of insomnia disorder, a Phase 2 clinical study of lemborexant in patients with irregular sleep-wake rhythm disorder and mild to moderate Alzheimer's dementia is underway.

Key Points: 
  • In addition to the treatment of insomnia disorder, a Phase 2 clinical study of lemborexant in patients with irregular sleep-wake rhythm disorder and mild to moderate Alzheimer's dementia is underway.
  • In this study, patients were randomized to receive placebo or one of three treatment regimens (lemborexant 5 mg, lemborexant 10 mg, zolpidem ER 6.25 mg).
  • During the active-only treatment period, patients who received placebo during the first period were re-randomized to receive lemborexant 5 mg or 10 mg.
  • Patients who received active treatment during the first period continued on the treatment to which they were originally randomized.

Global n-Butanol Market 2017-2018 & Forecast to 2022 with Arkema, BASF, DowDuPont, Eastman Chemical, Mitsubishi Chemical & OXEA Dominating

Retrieved on: 
Wednesday, November 14, 2018
Chemistry, Sustainable development, GABAA receptor positive allosteric modulators, Hypnotics, Sedatives, Energy, Primary alcohols, Butanol, Biofuel, Butanol fuel

The global n-butanol market to grow at a CAGR of 4.72% during the period 2018-2022.

Key Points: 
  • The global n-butanol market to grow at a CAGR of 4.72% during the period 2018-2022.
  • Global n-Butanol Market 2018-2022, has been prepared based on an in-depth market analysis with inputs from industry experts.
  • The use of n- butanol in end- use and industrial applications will growth of the global n- butanol market.
  • The increasing demand for biofuel and the superior characterizes of n- butanol can have a considerable impact the market.