GABAA receptor positive allosteric modulators

Neurelis Announces Five Poster Presentations for the Annual Meeting of the American Academy Of Neurology

Retrieved on: 
Monday, April 19, 2021
Drugs, GABAA receptor positive allosteric modulators, Chloroarenes, Lactams, Benzodiazepines, Anxiolytics, Clinical medicine, Psychoactive drugs, Diazepam, Seizure, Neonatal seizure, Lacosamide

In addition, the data shows that patients reported feeling like their usual self within two hours after VALTOCO administration.

Key Points: 
  • In addition, the data shows that patients reported feeling like their usual self within two hours after VALTOCO administration.
  • To be able to continue on with your day is very meaningful for patients with seizure clusters.
  • In a long-term, open-label, repeat-dose clinical trial, the safety of VALTOCO was evaluated, and more than 4,000 seizures were treated.
  • Serious and fatal adverse reactions, including "gasping syndrome", can occur in neonates and low-birth-weight infants treated with benzyl alcohol-preserved drugs, including VALTOCO.

Marinus Pharmaceuticals Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

Retrieved on: 
Monday, April 12, 2021
Biotechnology, Pharmaceutical, Health, Clinical trials, Anticonvulsants, GABAA receptor positive allosteric modulators, Ketones, Neurosteroids, Sterols, Chemical compounds, Ganaxolone, Chemistry

b'Marinus Pharmaceuticals, Inc. (Nasdaq: MRNS) (the \xe2\x80\x9cCompany\xe2\x80\x9d or \xe2\x80\x9cMarinus\xe2\x80\x9d), a pharmaceutical company dedicated to the development of innovative therapeutics to treat rare seizure disorders, today announced the grant of an inducement award to Steven Pfanstiel, Marinus\xe2\x80\x99 newly-hired Chief Financial Officer and Treasurer.

Key Points: 
  • b'Marinus Pharmaceuticals, Inc. (Nasdaq: MRNS) (the \xe2\x80\x9cCompany\xe2\x80\x9d or \xe2\x80\x9cMarinus\xe2\x80\x9d), a pharmaceutical company dedicated to the development of innovative therapeutics to treat rare seizure disorders, today announced the grant of an inducement award to Steven Pfanstiel, Marinus\xe2\x80\x99 newly-hired Chief Financial Officer and Treasurer.
  • The stock option was granted as an inducement material to Mr. Pfanstiel entering into employment with Marinus in accordance with Nasdaq Listing Rule 5635(c)(4), and is subject to the terms and conditions of the award agreement covering such grant.\nMarinus Pharmaceuticals, Inc. is a pharmaceutical company dedicated to the development of innovative therapeutics to treat rare seizure disorders.
  • Ganaxolone is a positive allosteric modulator of GABAA receptors that acts on a well-characterized target in the brain known to have anti-seizure, antidepressant and anti-anxiety effects.
  • Marinus undertakes no obligation to update or revise any forward-looking statements.

SK life science Reports Effectiveness of Long-Term Use with Cenobamate

Retrieved on: 
Thursday, April 15, 2021
Life sciences, Health sciences, Health, Chaebol, SK Group, Pharmaceutical industry, Anticonvulsants, GABAA receptor positive allosteric modulators, Sodium channel blockers, Biopharmaceutical, Pharmaceutical industry in India, Phenytoin

The objectives of the study included the characterization of the long-term safety of cenobamate and to understand how to best add cenobamate to regimens that included phenytoin or phenobarbital.

Key Points: 
  • The objectives of the study included the characterization of the long-term safety of cenobamate and to understand how to best add cenobamate to regimens that included phenytoin or phenobarbital.
  • Further increases to 400 mg/day using bi-weekly 50 mg/day increments were allowed.\nCenobamate was discovered and developed by SK Biopharmaceuticals and SK life science.
  • For more information, visit SK Biopharmaceuticals\' website at www.skbp.com/eng and SK life science\'s website at www.SKLifeScienceInc.com .\nBoth SK Biopharmaceuticals and SK life science are part of SK Group, one of the largest conglomerates in Korea.
  • SK Inc., the parent company of SK Biopharmaceuticals, continues to enhance its portfolio value by executing long-term investments witha number ofcompetitive subsidiaries in various business areas, including pharmaceuticals and life science, energy and chemicals, information and telecommunication, and semiconductors.

HealthPoint Plus and Trūman Rx establish strategic partnership

Retrieved on: 
Thursday, April 15, 2021
Organ systems, Organic compounds, Chemical compounds, Androstanes, Testosterone, Enones, Estrogens, GABAA receptor positive allosteric modulators, Telehealth, Healthpoint, Androgen replacement therapy, Harry S. Truman

b'DENVER, April 14, 2021 /PRNewswire/ -- National telehealth provider HealthPoint Plus, an innovative leader in subscription-based telehealth, formed a strategic partnership with the disruptive telehealth testosterone replacement therapy startup Truman Rx (Truman).

Key Points: 
  • b'DENVER, April 14, 2021 /PRNewswire/ -- National telehealth provider HealthPoint Plus, an innovative leader in subscription-based telehealth, formed a strategic partnership with the disruptive telehealth testosterone replacement therapy startup Truman Rx (Truman).
  • The partnership expands the reach of Truman while increasing the services available through HealthPoint Plus.\nTruman founder and CEO, David Hall, said of the partnership, "This is a big win for both companies and men who are needlessly suffering the consequences of low testosterone.
  • Our partnership with HealthPoint Plus allows us to expand our reach across the U.S. and enables us to continue honing our focus on creating a better experience for men who want access to high-quality testosterone therapy.
  • "\nWith COVID-19 reshaping how healthcare is provided, HealthPoint Plus CEO Bob Goddard sees it as imperative to increase the services that are available.

New startup Trūman Rx launches to expand access to testosterone therapy

Retrieved on: 
Wednesday, April 14, 2021
Organic compounds, Chemical compounds, Receptor agonists, Testosterone, Androstanes, Enones, Estrogens, GABAA receptor positive allosteric modulators, Telehealth, Androgen replacement therapy, Harry S. Truman

b'DENVER, April 14, 2021 /PRNewswire/ -- In an effort to increase access to testosterone replacement therapy for men, Colorado-based startup Truman Rx (Truman) is launching an online, innovative telehealth service for testosterone replacement therapy (TRT).

Key Points: 
  • b'DENVER, April 14, 2021 /PRNewswire/ -- In an effort to increase access to testosterone replacement therapy for men, Colorado-based startup Truman Rx (Truman) is launching an online, innovative telehealth service for testosterone replacement therapy (TRT).
  • Phase I of the launch will focus primarily in Colorado and New Mexico with plans to rapidly expand nationwide in 2021.
  • "\nVisit www.trumanrx.com for more information.\nTruman is a subscription-based telehealth service that helps men access testosterone replacement therapy from the comfort of their homes.
  • The Truman model is designed to be a better experience than brick-and-mortar clinics by providing therapy via videoconference and direct-to-consumer shipping.

Tolmar Publishes Study in the February Issue of Journal of Urology on the Impact of Late Dosing on Testosterone Suppression with Two Different Leuprolide Acetate Formulations: In Situ Gel and Microsphere - An Analysis of US Clinical Data

Retrieved on: 
Monday, April 12, 2021
Organ systems, Hormones, Branches of biology, Testosterone, Androstanes, Enones, Estrogens, GABAA receptor positive allosteric modulators, Androgen deprivation therapy, Gonadotropin-releasing hormone agonist, Leuprorelin, Prostate cancer

Leuprolide acetate is the most commonly used drug for androgen deprivation therapy (ADT) in men with advanced prostate cancer.

Key Points: 
  • Leuprolide acetate is the most commonly used drug for androgen deprivation therapy (ADT) in men with advanced prostate cancer.
  • The article reported the impact on testosterone suppression of late dosing of GnRH agonists in general.\nAndrogen deprivation therapy (ADT) is the standard of care for the treatment of advanced prostate cancer.
  • It aims to reduce circulating testosterone (T) to castration levels in order to remove the \'fuel\' that simulates cancer cells to grow.
  • Information about ELIGARD is available at www.eligard.com .\nELIGARD (leuprolide acetate for injectable suspension) is a medicine for the treatment of advanced prostate cancer.

Global Ethylene (Value, Volume) Market Report 2021: Analysis by Feedstock, Application, End-Use, Region, Market Insights, Covid-19 Impact, Competition and Forecast 2020-2025 - ResearchAndMarkets.com

Retrieved on: 
Friday, April 9, 2021
Other Manufacturing, Manufacturing, Organic compounds, Chemistry, Physical sciences, Industrial gases, Alkanes, Commodity chemicals, GABAA receptor positive allosteric modulators, Fuel gas, Ethylene, Ethane, Polyethylene, Propane

The "Global Ethylene Market (Value, Volume) - Analysis by Feedstock, Application, End-Use, by Region, by Country (2020 Edition): Market Insights, Covid-19 Impact, Competition and Forecast (2020-2025)" report has been added to ResearchAndMarkets.com's offering.

Key Points: 
  • The "Global Ethylene Market (Value, Volume) - Analysis by Feedstock, Application, End-Use, by Region, by Country (2020 Edition): Market Insights, Covid-19 Impact, Competition and Forecast (2020-2025)" report has been added to ResearchAndMarkets.com's offering.
  • The factors contributing to the growth of the market are the expansion of the food industry and high demand for polyethylene.
  • Among the Feedstock segment in the Ethylene market (Naphtha, Ethane, Propane and Butane), Naphtha segment leads the market.
  • Further, growing packaging, automotive, construction, and textile end-use industries are anticipated to boost the Asia Pacific ethylene market.

International Experts Provide Consensus on How to Administer Testosterone to Postmenopausal Women

Retrieved on: 
Thursday, April 1, 2021
Organ systems, Endocrine system, Organic compounds, Androstanes, Estrogens, Enones, GABAA receptor positive allosteric modulators, Testosterone, Puberty, Menopause

BURNSVILLE, Minn., April 1, 2021 /PRNewswire/ --Today, the International Society for the Study of Women's Sexual Health (ISSWSH) published an in-depth, detailed evidence-based, peer-reviewed international guideline on how healthcare professionals should administer testosterone to postmenopausal women.

Key Points: 
  • BURNSVILLE, Minn., April 1, 2021 /PRNewswire/ --Today, the International Society for the Study of Women's Sexual Health (ISSWSH) published an in-depth, detailed evidence-based, peer-reviewed international guideline on how healthcare professionals should administer testosterone to postmenopausal women.
  • Although women naturally produce significant quantities of testosterone from puberty on, by the time they reach menopause, about 50% of their body's testosterone has been lost.
  • Against this void of FDA-approved options for women, healthcare professionals have devised many schemes to address their patients' testosterone needs.
  • ISSWSH has taken on the challenge of teaching clinicians about women's sexual health, following the mandate of the World Health Organization (WHO) that all women deserve good health, including sexual health.

9 million fake sedative pills removed from circulation by Hungarian and Norwegian Police

Retrieved on: 
Tuesday, March 30, 2021
Agencies of the European Union, Law enforcement in Europe, Government agencies, Criminal investigation, Government, GABAA receptor positive allosteric modulators, Lactams, Europol, Eurojust, Clonazepam, Counterfeit, Politi

Over 9 million counterfeit sedative tablets have been seized as a result of a joint operation between the Hungarian National Police (Magyar Rendrsg) and the Norwegian Police (Politi) with the support of Europol and Eurojust.

Key Points: 
  • Over 9 million counterfeit sedative tablets have been seized as a result of a joint operation between the Hungarian National Police (Magyar Rendrsg) and the Norwegian Police (Politi) with the support of Europol and Eurojust.
  • The criminals were producing counterfeit Clonazepam tablets in an underground laboratory.
  • The counterfeit pills were sold across Europe, with Norway being one of the main destinations.
  • Europols Analysis Project COPY falling under Europols European Economic and Financial Crime Centre (EFECC) was central in this investigation.

Global Inhaled Nitric Oxide Markets, 2020-2027 - Ongoing R&D Activities Leading to New Application Areas in the Healthcare Industry

Retrieved on: 
Friday, March 26, 2021
Chemistry, Physical sciences, Chemical compounds, Oxides, Gaseous signaling molecules, Nitrogen cycle, GABAA receptor positive allosteric modulators, NMDA receptor antagonists, Nitric oxide, Lead(II,IV) oxide, Biological functions of nitric oxide

The global inhaled nitric oxide market was valued at $634.4 million in 2019 and is estimated to reach $1,180.98 million by 2027, registering a CAGR of 8.1% from 2020-2027.

Key Points: 
  • The global inhaled nitric oxide market was valued at $634.4 million in 2019 and is estimated to reach $1,180.98 million by 2027, registering a CAGR of 8.1% from 2020-2027.
  • Nitric oxide (iNO) is selective pulmonary vasodilation and is delivered to the patient via mechanical ventilation after dilution with an oxygen/air mixture nitric oxide delivery system.
  • Further, clinical trials evaluating the use of inhaled nitric oxide for numerous indications are ongoing.
  • Conversely, ongoing R&D activities leading to new application areas in the healthcare industry are expected to provide lucrative opportunities for the expansion of the global market in the near future.