Enhanced Potential of Myricx’s NMT Inhibitor Payloads with Dual Senolytic and Cytotoxic Modes of Action as ADC Cancer Therapies
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Monday, November 27, 2023
Drug resistance, UKRI, Cellular senescence, Metastasis, Nature Cell Biology, Protein, Medicine, ICS, Research, Chemical biology, Imperial College London, Spacecraft, COPI, CRUK, NMT, ARF1, Cancer, GSK, Notifiable disease, Laboratory, Inflammation, Cell, Phenotype, Medical school, Data, ADC, Francis Crick Institute
Senescent, or so called ‘zombie’ cells, can have deleterious effects on tissue function as they are persistent and secrete many proteins.
Key Points:
- Senescent, or so called ‘zombie’ cells, can have deleterious effects on tissue function as they are persistent and secrete many proteins.
- Small-molecule drugs that selectively eliminate senescent cells, known as senolytics, provide a promising novel strategy for treating multiple diseases, including cancer, fibrotic diseases, and age-related conditions.
- Overall, the study demonstrated that senescent cells rely on a hyperactive secretory apparatus and that this secretory phenotype is dependent on NMT and inhibiting NMT kills senescent cells.
- Combined with the cytotoxic effect of NMTis, the senolytic mechanism has the potential to induce deeper and more durable responses in treating tumours than purely cytotoxic payloads.