Gába

FDA Clears LPCN 1154 IND Application for a Phase 2 Postpartum Depression Study

Retrieved on: 
Monday, June 14, 2021
Branches of biology, Neurochemistry, GABAA receptor positive allosteric modulators, Gába, GABAA receptor, Allosteric modulator, gamma-Aminobutyric acid, Allosteric regulation

PPD, a major depressive disorder that is under diagnosed in US, impacts approximately 1 in 7 women after giving birth.

Key Points: 
  • PPD, a major depressive disorder that is under diagnosed in US, impacts approximately 1 in 7 women after giving birth.
  • The active moiety in LPCN 1154 is an endogenous positive allosteric modulator of -aminobutyric acid ("GABAA") receptor.
  • Lipocine's clinical development pipeline includes: TLANDO, LPCN 1144, TLANDO XR, LPCN 1148, LPCN 1154, and LPCN 1107.
  • LPCN 1154 is an oral neuro-steroid targeted for the treatment of post-partum depression.

Saniona to Present Preclinical Data on SAN711 at the 7th Congress of the European Academy of Neurology

Retrieved on: 
Tuesday, June 8, 2021
Branches of biology, Neurochemistry, Gába, Transmembrane receptors, GABAA receptor, GABA receptor, gamma-Aminobutyric acid, Allosteric regulation, Allosteric modulator

SAN711 is a first-in-class positive allosteric modulator of GABA-A 3 that was designed using Sanionas ion channel drug discovery engine.

Key Points: 
  • SAN711 is a first-in-class positive allosteric modulator of GABA-A 3 that was designed using Sanionas ion channel drug discovery engine.
  • While existing molecules target all GABA-A receptors indiscriminately, SAN711 selectively enhances the effects of GABA-A on 3 containing receptors.
  • Saniona also plans to continue to share its data on SAN711 and other preclinical programs in additional scientific and investor forums.
  • Saniona expects to begin a Phase 1 study of SAN711 in healthy volunteers in mid-2021, with data expected in early 2022.

Pharm Origins Announces the Release of GABASOM Sublingual Sleep Formula

Retrieved on: 
Friday, May 10, 2019
Branches of biology, Neurotransmitters, Aminobutyric acid, Gába, Neuroscience

ATLANTA, May 10, 2019 /PRNewswire-PRWeb/ -- Pharm Origins, a leading US based nutraceutical formulator and manufacturer has announced the official 2019 release of sleep sublingual, Gabasom.

Key Points: 
  • ATLANTA, May 10, 2019 /PRNewswire-PRWeb/ -- Pharm Origins, a leading US based nutraceutical formulator and manufacturer has announced the official 2019 release of sleep sublingual, Gabasom.
  • The science of Gabasom is based around the extensive research relating to gamma-Aminobutyric acid (GABA) and the induction of sleep.
  • "Sleep is a major biological function that many of us take for granted," stated Clint Winters, Pharm Origins spokesperson and noted health researcher.
  • Pharm Origins proudly supports the American economy and all of Pharm Origins products are made in the United States at their Atlanta, Georgia facility.

Okayama University Research: Inflammation in the Brain Enhances the Side-effects of Hypnotic Medication

Retrieved on: 
Wednesday, March 6, 2019
Branches of biology, Drugs, Neurochemistry, GABAA receptor positive allosteric modulators, Ion channels, Neurotransmitters, G protein-coupled receptors, Gába, Diazepam, gamma-Aminobutyric acid, GABA receptor, Receptor

BZDs act by activating a receptor in the brain known as the GABAA receptor (GABAR).

Key Points: 
  • BZDs act by activating a receptor in the brain known as the GABAA receptor (GABAR).
  • However, because drugs like BZDs can mimic these chemicals, they are used to stimulate the activity of GABAR in the lab.
  • The prolongation of reflex loss seen in mice given diazepam was thus linked directly to GABAR and inflammation in the brain.
  • GABA attaches to its receptor (GABAR) on the brain cells and induces inhibitory effects i.e., it decreases brain activity by calming it down.

Okayama University Research: Inflammation in the Brain Enhances the Side-effects of Hypnotic Medication

Retrieved on: 
Wednesday, March 6, 2019
Branches of biology, Drugs, Neurochemistry, GABAA receptor positive allosteric modulators, Ion channels, Neurotransmitters, G protein-coupled receptors, Gába, Diazepam, gamma-Aminobutyric acid, GABA receptor, Receptor

BZDs act by activating a receptor in the brain known as the GABAA receptor (GABAR).

Key Points: 
  • BZDs act by activating a receptor in the brain known as the GABAA receptor (GABAR).
  • However, because drugs like BZDs can mimic these chemicals, they are used to stimulate the activity of GABAR in the lab.
  • The prolongation of reflex loss seen in mice given diazepam was thus linked directly to GABAR and inflammation in the brain.
  • GABA attaches to its receptor (GABAR) on the brain cells and induces inhibitory effects i.e., it decreases brain activity by calming it down.

GO GABA Founder Launches Campaign Iwantmybusinessback.com to Raise Awareness for Entrepreneurs

Retrieved on: 
Tuesday, February 12, 2019
Branches of biology, Neurotransmitters, Neurochemistry, Neuroscience, Amino acids, Aminobutyric acid, Gába, Ion channels

GABA (Gamma-Aminobutyric Acid) is said to help sharpen the mind, providing clarity and focus.

Key Points: 
  • GABA (Gamma-Aminobutyric Acid) is said to help sharpen the mind, providing clarity and focus.
  • Initial commercialization in Mexico and select European countries enabled him to commission further research and attract start-up investment.
  • The founder of GO GABA wants to raise his voice and invite the public in general and other entrepreneurs to share their own experiences.
  • GO GABA was a winner in the Binational Mexico-France contest organized by the Mexican French Council for Entrepreneurship and Innovation.

GO GABA Founder Launches Campaign Iwantmybusinessback.com to Raise Awareness for Entrepreneurs

Retrieved on: 
Tuesday, February 12, 2019
Branches of biology, Neurotransmitters, Neurochemistry, Neuroscience, Amino acids, Aminobutyric acid, Gába, Ion channels

GABA (Gamma-Aminobutyric Acid) is said to help sharpen the mind, providing clarity and focus.

Key Points: 
  • GABA (Gamma-Aminobutyric Acid) is said to help sharpen the mind, providing clarity and focus.
  • Initial commercialization in Mexico and select European countries enabled him to commission further research and attract start-up investment.
  • The founder of GO GABA wants to raise his voice and invite the public in general and other entrepreneurs to share their own experiences.
  • GO GABA was a winner in the Binational Mexico-France contest organized by the Mexican French Council for Entrepreneurship and Innovation.

GABA-Receptor Modulation in the Treatment of Neurological Diseases

Retrieved on: 
Tuesday, December 4, 2018
Neuroscience, Biology, Neurochemistry, Neurotransmitters, G protein-coupled receptors, Transmembrane receptors, Ion channels, Gába, gamma-Aminobutyric acid, GABA receptor, Inhibitory postsynaptic potential, GABAA receptor

Neurons transmit information in the brain and communicate with each other through surface molecules called receptors.

Key Points: 
  • Neurons transmit information in the brain and communicate with each other through surface molecules called receptors.
  • The main inhibitory receptor in the mammalian brain, GABA-A-receptors (GABAARs), are activated by the neurotransmitter GABA, which is released from neurons.
  • Thus, modulation of the signaling pathways that regulate s-GABARs activity may provide new and safer treatments for epilepsy.
  • Dr. Sylantyev said that "GABA-independent modulation of spontaneously opening GABA-receptors is a perspective direction for the search for new anti-epileptic drugs free from common side effects."

GHB Intellect Announces Expansion of Service Offerings with IP Portfolio Valuation and Monetization Strategy

Retrieved on: 
Monday, June 4, 2018
Neurochemistry, Neuroscience, Neurophysiology, Intellectual property law, Patent law, Drug culture, Gába, gamma-Hydroxybutyric acid, Rape, Patent portfolio, Intellectual property

Having represented hundreds of clients across a wide spectrum of industries and technologies, GHB Intellect has unparalleled expertise when it comes to IP development, IP management, IP monetization, engineering, and litigation support.

Key Points: 
  • Having represented hundreds of clients across a wide spectrum of industries and technologies, GHB Intellect has unparalleled expertise when it comes to IP development, IP management, IP monetization, engineering, and litigation support.
  • GHB Intellect has also announced a willingness to work on a contingency basis with medium sized companies possessing relatively large patent portfolios.
  • When GHB Intellect conducts an initial review of the IP portfolio, they first confirm that the opportunity exists and will then work on either a full contingency or semi-contingency plan for the sale, licensing or use of the IP included in the patent portfolio.
  • At GHB Intellect, we harness our top-notch technical expertise and extensive resources to provide industry-leading intellectual property consulting services to our clients.

GHB Intellect Announces Expansion of Service Offerings with IP Portfolio Valuation and Monetization Strategy

Retrieved on: 
Monday, June 4, 2018
Neurochemistry, Neuroscience, Neurophysiology, Intellectual property law, Patent law, Drug culture, Gába, gamma-Hydroxybutyric acid, Rape, Patent portfolio, Intellectual property

Having represented hundreds of clients across a wide spectrum of industries and technologies, GHB Intellect has unparalleled expertise when it comes to IP development, IP management, IP monetization, engineering, and litigation support.

Key Points: 
  • Having represented hundreds of clients across a wide spectrum of industries and technologies, GHB Intellect has unparalleled expertise when it comes to IP development, IP management, IP monetization, engineering, and litigation support.
  • GHB Intellect has also announced a willingness to work on a contingency basis with medium sized companies possessing relatively large patent portfolios.
  • When GHB Intellect conducts an initial review of the IP portfolio, they first confirm that the opportunity exists and will then work on either a full contingency or semi-contingency plan for the sale, licensing or use of the IP included in the patent portfolio.
  • At GHB Intellect, we harness our top-notch technical expertise and extensive resources to provide industry-leading intellectual property consulting services to our clients.