Genome Biology

Singular Genomics Showcases New G4X™ Spatial Sequencer at AGBT and Announces Significant Advances in Throughput, Quality, and Usability for G4® Sequencing Platform

Retrieved on: 
Monday, February 5, 2024

Singular unveiled the G4X™ Spatial Sequencer as a high-throughput in situ spatial sequencing platform capable of simultaneous direct RNA sequencing, targeted transcriptomics, proteomics and fluorescent H&E from formalin-fixed, paraffin-embedded (FFPE) tissues.

Key Points: 
  • Singular unveiled the G4X™ Spatial Sequencer as a high-throughput in situ spatial sequencing platform capable of simultaneous direct RNA sequencing, targeted transcriptomics, proteomics and fluorescent H&E from formalin-fixed, paraffin-embedded (FFPE) tissues.
  • As an upgrade to the G4® Sequencing Platform, the G4X is expected to position Singular to be the only company worldwide to offer capabilities for tissue-based in situ spatial multiomics and NGS on the same instrument.
  • The G4X Spatial Sequencer is on display at the conference, alongside performance data from technology access collaborations with top academic centers.
  • Singular also announced updates to the G4, the industry-leading benchtop sequencing system for speed, flexibility, and power.

Vizgen Installs 100th MERSCOPE® Instrument

Retrieved on: 
Tuesday, July 25, 2023

Vizgen , the life science company dedicated to improving human health by visualizing single-cell spatial genomics information, today announced that it has installed its 100th MERSCOPE instrument in the Single Cell Genomics Core at the Baylor College of Medicine Department of Molecular and Human Genetics led by Dr. Rui Chen.

Key Points: 
  • Vizgen , the life science company dedicated to improving human health by visualizing single-cell spatial genomics information, today announced that it has installed its 100th MERSCOPE instrument in the Single Cell Genomics Core at the Baylor College of Medicine Department of Molecular and Human Genetics led by Dr. Rui Chen.
  • View the full release here: https://www.businesswire.com/news/home/20230725541683/en/
    Terry Lo, President and CEO of Vizgen with Rui Chen, Ph.D., Professor of Molecular and Human Genetics and Director of the Center of Single Cell Omics at the Baylor College of Medicine.
  • (Photo: Business Wire)
    Genetics plays an important role in human visual disorders which affect more than 30 million people in the United States alone1.
  • “It is extremely gratifying that Dr. Chen will be the recipient of the 100th installation of our MERSCOPE Platform as a longstanding supporter of Vizgen and the power of spatial imaging,” said Terry Lo, President and CEO of Vizgen.

South Korean Biotech, ToolGen Leads the Development of Numerous Cutting-Edge Genome Editing Techniques

Retrieved on: 
Tuesday, April 18, 2023

Not anymore; Toolgen, a South Korea-based biotech company, has reported three breakthrough techniques in top-tier scientific journals.

Key Points: 
  • Not anymore; Toolgen, a South Korea-based biotech company, has reported three breakthrough techniques in top-tier scientific journals.
  • PEs are powerful tools that allow for more precise genome editing, but until now, methods for predicting off-target effects have relied on analyzing the activity of Cas9 nucleases or nickases.
  • This puts Toolgen's patent strategies on the high ground as Toolgen can now evergreen its patent via using its biobetter Sniper2L.
  • Now the torch has been passed to other sectors, and Toolgen, a South Korea-based biotech, has proudly joined the league of innovators for genome editing."

NuProbe Closes $50M in New Fundraising

Retrieved on: 
Thursday, June 2, 2022

"In the past year, NuProbe has made great strides in new technology innovation, product development, and business expansion.

Key Points: 
  • "In the past year, NuProbe has made great strides in new technology innovation, product development, and business expansion.
  • "Panlin Capital is committed to supporting NuProbe and its mission and looks forward to NuProbe's continued progress and success."
  • Since NuProbe's last round of fundraising in 2021, NuProbe has engaged in research collaborations with several multinational companies, as well as clinical collaborations with over 400 hospitals.
  • Simultaneously, our recently published Quantitative Amplicon Sequencing (QASeq) technology delivers best-in-class sensitivity for copy number variations," said David Zhang,Co-Founder of NuProbe Global and CEO of NuProbe USA, a fully owned subsidiary of NuProbe Global.

Chung-Ang University Researchers Unravel Role of Cohesins In Embryonic Stem Cell Division

Retrieved on: 
Tuesday, May 31, 2022

SEOUL, South Korea, May 31, 2022 /PRNewswire/ -- Chromosomes undergo precise structural changes at a molecular level during the different phases of cell division. These changes occur at a high level of accuracy to prevent genome instability. Genome instability resulting from broken, missing, or rearranged chromosomes has been found to be the root cause of cell death, carcinogenesis, and congenital disorders. Studying genomic instability helps researchers identify the causes of cancer and may lead to new advancements in their diagnosis and treatment

Key Points: 
  • SEOUL, South Korea, May 31, 2022 /PRNewswire/ -- Chromosomes undergo precise structural changes at a molecular level during the different phases of cell division.
  • Genome instability resulting from broken, missing, or rearranged chromosomes has been found to be the root cause of cell death, carcinogenesis, and congenital disorders.
  • Studying genomic instability helps researchers identify the causes of cancer and may lead to new advancements in their diagnosis and treatment
    Scientists have long deciphered the role played by cohesin during meiotic cell division.
  • Based on the existing information about meiotic cohesins, the team used ESCs derived from mice to analyze the expression pattern of mitotic cohesin components.

The MAQC Society Announces Publication of Next-Gen Sequencing Best Practice Articles in Nature Biotechnology

Retrieved on: 
Thursday, September 16, 2021

LITTLE ROCK, Ark., Sept. 16, 2021 /PRNewswire/ -- The Massive Analysis and Quality Control (MAQC) Society, an organization seeking to promote and advance reproducible science principles and quality control, today announced the publication of a collection of journal articles in the September issue of Nature Biotechnology (NBT) .

Key Points: 
  • LITTLE ROCK, Ark., Sept. 16, 2021 /PRNewswire/ -- The Massive Analysis and Quality Control (MAQC) Society, an organization seeking to promote and advance reproducible science principles and quality control, today announced the publication of a collection of journal articles in the September issue of Nature Biotechnology (NBT) .
  • The September NBT collection includes other successful SEQC2 research articles that appeared earlier this year in NBT, Genome Biology, and Genome Medicine.
  • For sequencing-community members wishing to construct or pressure-test the robustness of sequencing pipelines, this collection describes publicly available samples, data, and consensus results and recommendations.
  • In addition, the collection provides a sweeping assessment of experimental and algorithmic sequencing methods.