Artificial Intelligence System Predicts Consequences of Gene Modifications
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Wednesday, May 31, 2023
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SAN FRANCISCO, May 31, 2023 /PRNewswire/ -- Researchers at Gladstone Institutes, the Broad Institute of MIT and Harvard, and Dana-Farber Cancer Institute have turned to artificial intelligence (AI) to help them understand how large networks of interconnected human genes control the function of cells, and how disruptions in those networks cause disease.
Key Points:
- Theodoris and her team used Geneformer to shed light on how heart cells go awry in heart disease.
- "This approach will greatly advance our ability to design network-correcting therapies in diseases where progress has been obstructed by limited data."
- Some of those genes, in turn, impact other genes—or loop back and put the brakes on the first gene.
- However, other potentially important genes identified by Geneformer had not been previously associated with heart disease, such as the gene TEAD4.