Shelly Liddelow

Fluent BioSciences Partners with GenomeWeb and NYU Grossman School of Medicine's Liddelow Lab to Host Webinar on Revolutionary PIPseq scRNA-Seq Technology with Upcoming bioRxiv Publication

Retrieved on: 
Wednesday, May 17, 2023
Shelly Liddelow, Central nervous system, EST, Fluency, Laboratory, RNA, GenomeWeb, CNS, Vaccine

The Liddelow Lab has successfully deployed PIPseq for use in examining central nervous system (CNS) cells across a range of acute inflammation and genetic labeling models for high-throughput single-cell analysis in the mouse brain.

Key Points: 
  • The Liddelow Lab has successfully deployed PIPseq for use in examining central nervous system (CNS) cells across a range of acute inflammation and genetic labeling models for high-throughput single-cell analysis in the mouse brain.
  • The webinar will discuss an upcoming publication from the Liddelow Lab demonstrating how the PIPseq technique can accelerate single-cell research and showcase their successful deployment of PIPseq for CNS analysis.
  • "We are thrilled to partner with the Liddelow Lab and GenomeWeb to host this webinar and share our groundbreaking PIPseq technology with the scientific community," said Brian Mckernan, CEO of Fluent BioSciences.
  • The webinar is scheduled for May 18th,1pm EST and will feature a presentation from Dr. Shane Liddelow.

Gene Mutation May Explain Brain Cell Plaque Buildup in Alzheimer's Disease

Retrieved on: 
Wednesday, November 30, 2022
Doctor of Philosophy, Cure Alzheimer's Fund, National Institutes of Health, Cell, NYU Langone Health, Mutation, Gene, Hasel, Glaucoma, New York University Grossman School of Medicine, DNA, Bacteria, Brain, Enzyme, Alzheimer's Research UK, INPP5D, Physiology, Alzheimer's Association, Inflammation, Rockefeller Neuroscience Institute, Microglia, Parkinson's disease, NYU, Plaque, Icahn School of Medicine at Mount Sinai, Neurodegeneration, Multiple sclerosis, Journal, Mouse, Ophthalmology, Virus, Monroe Dunaway Anderson, Huntington's disease, Research, Human, Mount Sinai, BA, Vaccine, Pharmaceutical industry, Medical imaging, Antibiotics, Neuroscience, Dementia, MD, Shelly Liddelow, Alzheimer's disease, Medicine

The buildup of such clumps, also called plaque, sets off an immune response that can kill brain cells and may lead to the dementia associated with Alzheimer's disease.

Key Points: 
  • The buildup of such clumps, also called plaque, sets off an immune response that can kill brain cells and may lead to the dementia associated with Alzheimer's disease.
  • The new findings may offer a potential new target for therapies that directly affect the gene mutation, according to the study authors.
  • Notably, this cluster is known to produce molecules that trigger inflammation in Parkinson's disease, Huntington's disease, and various forms of dementia.
  • They compared these findings to previous research in humans with Alzheimer's disease, observing the same genetic changes in the gene cluster linked to plaque.