Norovirus Link to Crohn's Disease May Point to New Therapies
Retrieved on:
Wednesday, October 5, 2022
Diamond, National Institutes of Health, Biochemistry, Howard Hughes Medical Institute, The Kenneth Rainin Foundation, Disease, Virus, Infection, Crohn's disease, Pharmacology, Crohn's & Colitis Foundation, API5, Geisinger Health System, NYU, Diarrhea, New York University Grossman School of Medicine, Patient, Rockefeller University, Research, MPH, Nature, Harvard Medical School, NYU Langone Health, Cadwell, Mouse, Immune system, Vomiting, Mutation, PureTech Health, Doctor of Philosophy, Department, National, Bacteria, Injection, Pacific Biosciences, Apoptosis, Human, Vaccine, Pharmaceutical industry, Pfizer, Takeda, Genentech, MD, Norovirus, Microbiology
Norovirus, a common infection that causes vomiting and diarrhea, is one of several viruses and bacteria thought to trigger disease onset in Crohn's patients, but the field does not know why.
Key Points:
- Norovirus, a common infection that causes vomiting and diarrhea, is one of several viruses and bacteria thought to trigger disease onset in Crohn's patients, but the field does not know why.
- One clue emerged when past studies found that a certain genetic change (mutation) is present in most patients with the condition.
- This protein adds an extra layer of protection against immune damage, so even those with the mutation can have a healthy gut.
- However, the researchers also found that norovirus infection blocks T cell secretion of API5 in mice bred to have a rodent form of Crohn's disease, killing gut-lining cells in the process.