Vain

Merck Announces Plans to Conduct Clinical Trials of a Novel Investigational Multi-Valent Human Papillomavirus (HPV) Vaccine and Single-Dose Regimen for GARDASIL®9

Retrieved on: 
Wednesday, March 13, 2024

Separately, the company also plans to conduct clinical trials in both females and males to evaluate the efficacy and safety of a single-dose regimen of GARDASIL®9 (Human Papillomavirus 9-valent, recombinant), compared to the approved three-dose regimen.

Key Points: 
  • Separately, the company also plans to conduct clinical trials in both females and males to evaluate the efficacy and safety of a single-dose regimen of GARDASIL®9 (Human Papillomavirus 9-valent, recombinant), compared to the approved three-dose regimen.
  • Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.
  • The latest addition to the pipeline employs the company’s proprietary virus-like particle (VLP) technology to incorporate additional VLPs for expanded HPV type coverage.
  • These randomized, double-blind, multi-year clinical trials will examine the short and long-term efficacy and immunogenicity of a single-dose of GARDASIL 9 versus the currently approved three-dose regimen.

Patrick White was the first Australian writer to win the Nobel Prize in Literature – 50 years later, is he still being read?

Retrieved on: 
Wednesday, October 4, 2023

Did you know that 2023 marks the 50th anniversary of Patrick White winning the Nobel Prize in Literature, the first Australian writer to be so honoured?

Key Points: 
  • Did you know that 2023 marks the 50th anniversary of Patrick White winning the Nobel Prize in Literature, the first Australian writer to be so honoured?
  • Until last week, neither did I.
  • As a lover of White’s writing, I was shocked by my own lack of awareness, which was quickly overshadowed by the realisation that seemingly everyone had overlooked it.

Cultural cringe

    • There should have been conferences and celebrations – a festival that would leave the Opera House in the dust!
    • The 50th anniversary of White’s best-known novel Voss in 2007 was marked with a two-day symposium.
    • The cringe, Phillips wrote,
      mainly appears in an inability to escape needless comparisons.
    • The Australian reader, more or less consciously, hedges and hesitates, asking himself ‘Yes, but what would a cultivated Englishman think of this?’ When it comes to White’s reception, especially post-Nobel, the cringe is everywhere apparent.
    • Here were signs, at last, that Australians could produce real literature – at least, according to Europe and Britain.

A writer unread?

    • He infamously chastised mainstream Australian writing as little more than the “dreary dun-coloured offspring of journalistic realism”.
    • A.D. Hope’s similarly infamous review of The Tree of Man judged the novel to be “pretentious and illiterate verbal sludge”.
    • White’s uneven reception reflected an anxiety about what Australian literature actually was.
    • The preeminent questions asked in undergraduate Australian literature units are still: What is Australian literature?
    • That Watts and Tsiolkas are both novelists themselves might explain their fervour for White, a writer who fits well under the moniker a “writer’s writer”.

Reputation

    • The question that is asked of White is not just “should we read him”, but should we study him.
    • White’s reputation as a canonical writer, and more specifically as a “difficult” modernist author and a “writer’s writer”, is a disaster when it comes to getting people, including students, to actually read him.
    • He is not only the kind of writer one would expect to study at school and university; many people assume he can only be read in those contexts.
    • Of course, White is a difficult writer, though it is often overlooked that he can also be funny, especially in his depictions of suburbia.
    • She had noticed seed at Woolworths and Coles; it was only a matter of choosing.
    • So far departed from the rational level to which she had determined to adhere, her own thoughts were grown obscure, even natural.
    • Vain or not, it would seem, maybe until now, that the award has been the crowning achievement.

Long-Term Follow-up Data on Sustained Immunogenicity and Safety for GARDASIL®9 Published in Pediatrics

Retrieved on: 
Tuesday, September 5, 2023

The oropharyngeal and head and neck cancer indication is approved under accelerated approval based on effectiveness in preventing HPV-related anogenital disease.

Key Points: 
  • The oropharyngeal and head and neck cancer indication is approved under accelerated approval based on effectiveness in preventing HPV-related anogenital disease.
  • Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.
  • As part of the primary objective of immunogenicity, data showed sustained HPV-antibody responses at 10 years after the third dose in boys and girls.
  • With the exception of cervical cancer, there is no routinely recommended screening for the detection of HPV-related cancers.

Washington Monthly's College Rankings Stand Out as U.S. News Faces Scrutiny for Distorted Numbers

Retrieved on: 
Monday, August 29, 2022

This summer, U.S. News "deranked" Columbia University and removed Villanova University from its Best Value list.

Key Points: 
  • This summer, U.S. News "deranked" Columbia University and removed Villanova University from its Best Value list.
  • The common source of these controversies is that U.S. News's metrics rely on a proprietary survey on which colleges have an incentive to cheat.
  • Rob Wolfe examines "The Invisible College Barrier," which are admissions requirements for popular majors that rob underprivileged students of future incomeand their dreams.
  • Founded in 1969, theWashington Monthlyhas trained and published many of the biggest names in journalism, includingJon Meacham,Nicholas Lemann, Katherine Boo, andNicholas Confessore.