Issue 1 | Jotup

Journal of Pharmaceutical Analysis (JPA) Studies Find Promising Drug Candidates

Retrieved on:

Friday, March 29, 2024

XI'AN, China, March 29, 2024 /PRNewswire/ -- Understanding the underlying mechanisms of normal and pathological cellular processes is essential for developing new drugs. Fortunately, modern techniques and experimental methods have greatly accelerated progress. The latest issue of JPA features three articles in which candidate compounds for treating complex disorders were successfully identified, alongside their detailed mechanisms of action.

Key Points:

The first study investigated the use of metformin (Met), a drug used to manage type II diabetes, for treating benign prostate hyperplasia (BPH).
The article was published in Volume 14, Issue 1 of the journal in January 2024 .
Using the Drug Signatures Database, they identified hydralazine (HYD), a potent arterial vasodilator, as a potential UBA52 disruptor.
Further studies will hopefully clarify the intricate connections among cellular processes, diseases, and potential drugs, paving the way for precise and efficient therapies.

An update on the accuracy of recent Eurosystem/ECB staff projections for short-term inflation

Retrieved on:

Wednesday, April 3, 2024

Issue 1, Electricity, Forecasting, Uncertainty, Database, Projection, ECB, COVID-19, Coronavirus, Climate, Policy, Food, Nature, BVAR, Bookkeeping

The low predictability of energy commodity prices (which surprised markets on the downside in 2023) explains a significant share of the recent errors in HICP inflation projections.

Key Points:

The low predictability of energy commodity prices (which surprised markets on the downside in 2023) explains a significant share of the recent errors in HICP inflation projections.
Eurosystem and ECB staff continue to refine their forecasting toolkits, providing additional analysis that informs projections in times of high uncertainty.

Korea University College of Medicine Identifies Hantavirus in South Korea Using a New Rapid Test, Paving Way for Early Outbreak Control

Retrieved on:

Thursday, February 29, 2024

Viral hemorrhagic fever, Virology, Hope, Branches of microbiology, Prevalence, Eisenmenger syndrome, Journal, Genomics, Issue 1, Shrew, Orthohantavirus, Research, DNA, Public, Vaccine

SEOUL, South Korea, Feb. 29, 2024 /PRNewswire/ -- Orthohantaviruses, highly transmissible zoonotic pathogens, are notorious for causing hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus cardiopulmonary syndrome in the Americas. With a significant impact on public health, they have been extensively researched for effective outbreak control and intervention strategies. Gyeonggi Province in South Korea has reported a significant number of HFRS cases, making it a critical area for epidemiological surveillance and understanding the genomic diversity of orthohantaviruses.

Key Points:

With a significant impact on public health, they have been extensively researched for effective outbreak control and intervention strategies.
Notably, the study showcased the application of Flongle sequencing, an innovative, cost-efficient, and rapid method, for detecting HTNV genomes.
"We developed a rapid and sensitive on-site diagnostic using a nanopore-based Flongle chip with a reasonable cost of around $100.
Title of original paper: High-resolution phylogeographical surveillance of Hantaan orthohantavirus using rapid amplicon-based Flongle sequencing, Republic of Korea

Korea University Study Explores a Novel and Precise Mitochondrial Gene Editing Method

Retrieved on:

Friday, February 23, 2024

Toxicity, Gene editing, File association, DSM-IV codes, DNA replication, Cell, RNA, Associate, Genome, A-DNA, Issue 1, Research, DNA, Mouse, Korea University, Vaccine

Targeted base editing of mammalian mtDNA is a powerful technology for modeling mitochondrial genetic diseases and developing potential therapies.

Key Points:

Targeted base editing of mammalian mtDNA is a powerful technology for modeling mitochondrial genetic diseases and developing potential therapies.
Programmable deaminases, which consist of a custom DNA-binding protein and a nucleobase deaminase, enable precise mtDNA editing.
Prof. Lee's research hints at a potential future in which the mitochondrial gene editing technology gains similar recognition.
The achievement of correcting mitochondrial A-to-G in mice not only highlights the efficacy of the novel gene editing method but also signals a significant step toward developing approved treatments for mitochondrial genetic diseases.

As Ohio and other states decide on abortion, anti-abortion activists look to rebrand themselves as not religious

Retrieved on:

Tuesday, November 7, 2023

Ohio voters will cast ballots on Nov. 7, 2023, to determine abortion rules in their state, joining six other states that have put the decisions before voters in ballot initiatives since 2022.

Key Points:

Ohio voters will cast ballots on Nov. 7, 2023, to determine abortion rules in their state, joining six other states that have put the decisions before voters in ballot initiatives since 2022.
Ohio residents will vote on “Issue 1,” which would amend the state constitution to explicitly protect an individual’s right to get an abortion.
Some anti-abortion activists in Ohio have said that Issue 1 is “too radical” for the state.
But I found that these activists also recognize that framing abortion as a human rights issue may appeal to a broader audience.

Perceptions of the anti-abortion movement

In my interviews, anti-abortion rights activists said they understood that the public views their movement as anti-woman and driven by conservative Christians.
These organizations are increasingly choosing to speak less about religion and more about human rights and science to combat the narrative that the anti-abortion movement is solely a Christian movement.
In the 1980s, Operation Rescue, which blockaded abortion clinics and had thousands of their activists arrested, brought an evangelical religious fervor to the anti-abortion movement.

The changing role of religion

While evangelicals remain a powerful voting bloc for Republicans, the percentage of Americans identifying as Christian has declined over the past 50 years from 90% to 63%.
At the same time, the percentage of Americans who identify as religiously unaffiliated has increased from 5% to 29%.
One activist I interviewed put it bluntly: “Why talk the Bible to people, many people, who say the Bible is a fairy tale?”

What anti-abortion organizations say

I analyzed how anti-abortion organizations use Facebook to promote their work.
At least on this social media platform, most anti-abortion organizations do not use religious language.
Some organizations use religious references in nearly all of their Facebook posts, while other groups make only passing references to religion.
More than 15% of the 193 anti-abortion organizations in my sample, however, make no religious references in their Facebook posts from June 2022 through September 2023.

Other findings

Approximately one-quarter of the 45 activists I interviewed, however, said their organizations are explicitly Christian.
When asked about the choice to frame anti-abortion arguments around faith, one advocate said, “We 100% present the faith and the theological argument of things.
For them, any loss of human life is tragic, whether it is from abortion, war or the death penalty.

Ohio’s vote

But Ohio is the first red state to vote on adding a right to abortion to the state’s constitution.
Ohio voters will be the ones to decide which way to move the issue forward.

Anne Whitesell does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Catholics for Choice Launches Billboard Blitz Ahead of Ohio Abortion Vote

Retrieved on:

Thursday, October 26, 2023

Comment, Respect, Election, Issue 1, Reproductive rights, Catholic Church, Birth, Buckeye, Roe v. Wade, YES, Multimedia, Birth control, Choice

WASHINGTON , Oct. 26, 2023 /PRNewswire-PRWeb/ -- Catholics for Choice Launches Billboard Blitz Ahead of Ohio Abortion VoteThe message: "Pro-Choice Catholics: You Are Not Alone. Vote YES on Issue 1"

Key Points:

Catholics for Choice is blanketing the Buckeye State with more than 30 billboards across Ohio, including in its seven largest metropolitan areas.
The signs read "63% of Catholics support legal abortion in all or most cases" and "Pro-Choice Catholics: You Are Not Alone" and tell them to "Vote YES on Issue 1."
The signs read "63% of Catholics support legal abortion in all or most cases" and "Pro-Choice Catholics: You Are Not Alone" and tell them to "Vote YES on Issue 1."
said:
"Catholics for Choice recognizes what is at stake on the Ohio ballot and how important it is for pro-choice Catholics in Ohio to know that they are not alone.

Monetary policy and housing investment in the euro area and the United States

Retrieved on:

Thursday, May 18, 2023

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Pusan National University Researchers Develop Portable Color-Changing Food Spoilage Sensor

Retrieved on:

Wednesday, March 22, 2023

Food, Cadaverine, Pusan National University, Food quality, Cheese, Temperature, Associate, Amine, PDA, Food storage, Bachelor of Arts, Biomaterials Science, Issue 1, Atomic mass, Meat, Food preservation, Medical imaging, Food chemistry

BUSAN, South Korea, March 22, 2023 /PRNewswire/ -- Ingesting biogenic amines released from spoiled food is harmful for the human body. Thus, it is important to detect these compounds during food storage and distribution to track spoilage. To this end, researchers have now combined polydiacetylene liposome and alginate solution to create hydrogel for developing a colorimetric food spoilage sensor. This novel sensor easily detects biogenic amines in liquid or vapor form by changing color from blue to red, without any complicated machinery.

Key Points:

Thus, it is important to detect these compounds during food storage and distribution to track spoilage.
To this end, researchers have now combined polydiacetylene liposome and alginate solution to create hydrogel for developing a colorimetric food spoilage sensor.
This motivated a team of researchers, including Prof. Sungbaek Seo, Associate Professor of Biomaterials Science at Pusan National University, to develop a portable molecular sensor that quickly detects the presence of BAs by changing colors.
Taken together, this portable PDA-based colorimetric sensor would facilitate the seamless monitoring of food spoilage during storage and distribution, and prevent health hazards arising from the ingestion of BAs.

Pusan National University Researchers Examine Combined Effects of Two Combustion Technologies on the Emission of Coal-Fired Boilers

Retrieved on:

Friday, March 17, 2023

Atmosphere, Pusan National University, Energy, Temperature, Pollutant, Coal, NOx, Acid rain, Rathen Open Air Stage, Issue 1, LPG, ETV, Health, Environment, Renewable energy, Natural gas

While there are ongoing efforts to transition to renewable energy resources, coal-fired power plants may not become obsolete just yet.

Key Points:

While there are ongoing efforts to transition to renewable energy resources, coal-fired power plants may not become obsolete just yet.
To this end, various combustion methods like air and staging and swirl flow have been proposed.
However, the efficacy of these technologies in mitigating the pollutant emissions while maximizing the burnout performance has remained unclear.
"Therefore, if these two technologies are appropriately combined and applied in real life, a synergistic effect that reduces the emission of air pollutants as well as improves combustion performance can be expected."

GIST Researchers Develop "AMP-BERT": A New AI-based "Finder" of Antimicrobial Peptides

Retrieved on:

Friday, February 24, 2023

GWANGJU, South Korea, Feb. 24, 2023 /PRNewswire/ -- Over the last few decades, antimicrobial resistance has become a major public health concern globally. This has led to a search for alternative methods of treating microbial infections. One such innovation is the discovery of antimicrobial properties of certain peptides. Antimicrobial peptides (AMPs) are short peptides found in most animals, plants, and microorganisms as a natural defense against infections. AMPs combat harmful bacteria via a nonspecific mechanism that prevents them from developing antimicrobial resistance. Despite these exceptional abilities, research on AMPs is being hindered because the existing systems for identifying candidate AMPs are like a black box, where the outputs are not easily interpretable for further analysis.

Key Points:

One such innovation is the discovery of antimicrobial properties of certain peptides.
Antimicrobial peptides (AMPs) are short peptides found in most animals, plants, and microorganisms as a natural defense against infections.
AMPs combat harmful bacteria via a nonspecific mechanism that prevents them from developing antimicrobial resistance.
The important peptide subregion information provided by this prediction platform can also be used to optimize the antibiotic efficiency of peptides.