SALTS

Terran Biosciences announces new breakthroughs in the chemistry of MDMA and its enantiomers and analogs, discovers new salts and polymorphs, publishes PCT application.

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Friday, May 26, 2023

MDMA is the most studied empathogen to date and has been shown to be an effective treatment for post-traumatic stress disorder (PTSD) in multiple phase 3 trials.

Key Points: 
  • MDMA is the most studied empathogen to date and has been shown to be an effective treatment for post-traumatic stress disorder (PTSD) in multiple phase 3 trials.
  • Historically, MDMA has only been developed as a single salt and the crystal structures of its enantiomers had not been characterized.
  • As previously reported, Terran found that the S enantiomer of MDEA had significant advantages over the (R)-MDEA in preclinical models.
  • Terran is also developing the S enantiomer of MBDB which was shown to have significant advantages over (R)-MBDB in preclinical models.

Terran Biosciences discovers what may be the first new salts, co-crystals, and polymorphs of psilocybin in history, publishes PCT patent application, and files psilocybin Drug Master File (DMF) with FDA

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Friday, May 19, 2023

Psilocybin is one of the main active compounds in psychedelic mushrooms and has been used by humans for thousands of years.

Key Points: 
  • Psilocybin is one of the main active compounds in psychedelic mushrooms and has been used by humans for thousands of years.
  • Recent clinical studies suggest psilocybin is efficacious in treating depression.
  • According to the literature, there are three main polymorphic forms of zwitterionic psilocybin: form A, form B, and form A' (A-Prime).
  • Terran also replicated this comprehensive set of studies with the psilocin prodrug O-acetylpsilocin, resulting in additional novel salts and polymorphs of that compound as well.

Terran Biosciences announces publication of four PCT patent applications covering breakthroughs in novel empathogens, including improved versions of methylone, ethylone, MDEA, MDAI, and MBDB

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Thursday, May 11, 2023

The discoveries include novel deuterated forms, enantiomerically pure forms, as well as novel salts, polymorphs, and co-crystals of racemic methylone, R-methylone and S-methylone.

Key Points: 
  • The discoveries include novel deuterated forms, enantiomerically pure forms, as well as novel salts, polymorphs, and co-crystals of racemic methylone, R-methylone and S-methylone.
  • Terran believes that therapeutic options for patients should be equally diverse, with unique psychedelics and empathogens tailored to specific patient needs.
  • Terran completed what is believed to be the first comprehensive salt and polymorph screen performed to date on this compound.
  • Terran completed additional improvements including the synthesis of deuterated forms of racemic methylone, R-methylone, and S-methylone with improved pharmacokinetics.

CONSUMERS GLOBALLY DEFLECT RESPONSIBILITY OF SODIUM INTAKE

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Thursday, March 3, 2022

The conundrum reveals itself. Consumers indicate that they would prefer their grocery store not sell high-sodium foods. In theory, this makes sense--If something is not available, behavior change is inevitable. However, in reality, consumers would not be happy if high-sodium foods were removed from store shelves. The survey indicated that the majority of consumers prioritize taste above all else when deciding what to eat and currently believe low-sodium foods are bland and tasteless.

Key Points: 
  • The SALTS Survey was conducted across seven global markets in North America, Europe and Asia-Pacific to understand consumers' attitudes towards sodium and identify opportunities to develop partnerships and tools to reduce sodium consumption overall.
  • The survey found the large majority of consumersrecognize various health benefits associated with reducing their sodium intake from health maintenance to illness prevention to increased longevity.
  • Sixty-four percent of consumers know that eating too much sodium is bad for their health, yet only thirty-seven percent pay attention to how much sodium they consume.
  • Sodium ranked six out of ten globally in consumers' food and nutrition priorities.