Dependent and independent variables

ICH M14 guideline on general principles on plan, design and analysis of pharmacoepidemiological studies that utilize real-world data for safety assessment of medicines Step 2b

Retrieved on: 
Sunday, June 2, 2024
Consensus, Sentinel, Real-World Evidence, NPV, Privacy, Smoking, Business analyst, Interest, Scope, Section 3, Missing data, Attention deficit hyperactivity disorder, World Health Organization, Thrombosis, Vaccination, Artificial intelligence, GVP, Element, ICD-10, ICD, Target, Clutch (eggs), MedDRA, Anaphylaxis, Data collection, Multi, Registry, Infant, International Society, Collection, Incidence, Clinical study design, FD, Replication (computing), Deference, Failure, CDM, Innovation Center station, Prevalence, Diagnosis, Mortality, Pregnancy, Person, Data analysis, Classification, Committee, Knowledge, Silver, PMID, Development, Roger Hawkins (drummer), Record, Len Bias, 1113, Polypharmacy, Sensitivity analysis, Protocol, Risk, European Medicines Agency, FDA, Real, Joint, Step, Quality control, Documentation, Standard of care, Health care, Accident, Checklist, Database, Birth weight, Statistics, Communication, Natural language processing, Table, Data Governance Act, Common data model, Study, Reproduction, Quality assurance, European, BMJ, Quality, Conducting, Comorbidity, NMPA, Knowledge Organization (journal), Drug development, DHT, Conceptual, ISPE, Adrenaline, Marketing, Cancer, EHR, Phenotype, Safety, Rehabilitation, Research design, HCPCS, Treatment, Allergy, Electronic health record, Validity, Death, MAH, Quality of life, 1128, Confidentiality, Selection bias, Prescription, Machine learning, Duration, CIOMS, Vaccine, ICMJE, Injury, Workplace, Section 5, National Cancer Institute, Bangladesh Technical Education Board, Interval (mathematics), Regulation, Data quality, Management, GCP, Digital, Software, Meta-analysis, SNOMED, Section 8, Use, Biology, QC, Uncertainty, Birth defect, PPV, FDN, Publication bias, Draft, Shareware, Frailty, Disulfiram-like drug, Guideline, Publishing, Gestational diabetes, De novo, Big data, Conduct, Medication, Bias, Immunodeficiency, EMA, Social media, International Classification of Diseases, History, Name, Data management, M10, Algorithm, Ageing, Natural history, SAP, Asian literature, Disability, QA/QC, Immortal, NDC, Book, Human voice, Central Statistics Office (India), Content, Birth, Frontiers Media, Metadata, RxNorm, Data governance, GPP, Structuring, Radiology, Benzodiazepine, Lash, User experience, Theft, Methodology, Objective, RWD, COMMUNICATION, DATA, Literature, Health information management, Clinical trial, Dependent and independent variables, Research, Patient, ATC, INTRODUCTION, TB, Section 13, Contraindication, Insurance, Concomitant, Data, Index, M14, Gestational age, Data curation, Biomarker, ICH, Paper, CHMP, Medical device

Key Points: 

    Bausch + Lomb Reports More Than 84 Million Units of Contact Lenses, Lens Care and Eye Care Materials Collected Through Innovative Recycling Programs

    Retrieved on: 
    Thursday, April 18, 2024

    Contact lenses, eye care and lens care materials are typically not processed in standard recycling facilities due to their small size and the type of plastic used to manufacture them.

    Key Points: 
    • Contact lenses, eye care and lens care materials are typically not processed in standard recycling facilities due to their small size and the type of plastic used to manufacture them.
    • Eye health packaging materials collected through the Bausch + Lomb recycling programs are used to create various post-consumer products like picnic tables and benches.
    • The Biotrue Eye Care Recycling program, which launched in April 2021, has collected nearly 825,000 eye drop single dose units, lens cases, lens solution caps, as well as all Biotrue-branded eye drop bottles2.
    • In addition to the U.S., Bausch + Lomb has a similar contact lens recycling program in Canada called Every Contact Counts .

    Central bank asset purchases and auction cycles revisited: new evidence from the euro area

    Retrieved on: 
    Friday, April 19, 2024

    Working Paper Series

    Key Points: 
      • Working Paper Series
        Federico Maria Ferrara

        Central bank asset purchases
        and auction cycles revisited:
        new evidence from the euro area

        No 2927

        Disclaimer: This paper should not be reported as representing the views of the European Central Bank
        (ECB).

      • Abstract
        This study provides new evidence on the relationship between unconventional monetary
        policy and auction cycles in the euro area.
      • The findings indicate that Eurosystem?s asset purchase flows mitigate
        yield cycles during auction periods and counteract the amplification impact of market volatility.
      • The dampening effect of central bank asset purchases on auction cycles is more sizeable and
        precisely estimated for purchases of securities with medium-term maturities and in jurisdictions
        with relatively lower credit ratings.
      • On the other hand, central banks may influence price dynamics in these markets, most notably
        through their asset purchase programmes.
      • If so, do central bank asset purchases
        affect bond yield movements around auction dates?
      • Auction cycles are present when secondary market yields rise in
        anticipation of a debt auction and fall thereafter, generating an inverted V-shaped pattern around auction
        dates.
      • ECB Working Paper Series No 2927

        3

        1

        Introduction

        The impact of central bank asset purchases on government bond markets is a focal point of economic and
        financial research.

      • If so,
        do central bank asset purchases shape yield sensitivity around auction dates?
      • The paper provides new evidence on the effects of Eurosystem?s asset purchases on secondary market
        yields around public debt auction dates.
      • The analysis builds on previous research based on aggregate data
        on central bank asset purchases and a shorter analysis period (van Spronsen and Beetsma 2022).
      • Using
        granular data on Eurosystem?s asset purchases offers an opportunity to shed light on the mechanisms linking
        unconventional monetary policy and auction cycles.
      • Given this legal constraint, the study
        hypothesises that the effect of asset purchases on 10-year auction cycles is mostly indirect, and goes via price
        spillovers generated by purchases of securities outside the 10-year maturity space.
      • Taken together, these results provide new evidence about auction cycles in Europe and contribute to a
        larger literature on the flow effects of central bank asset purchases on bond markets.
      • Section 4 offers descriptive evidence about auction cycles in the euro area.
      • Auction cycles are defined by the presence of an inverted V-shaped pattern in secondary market yields
        around primary auctions.
      • That is, government bond yields rise in the run-up to the date of the auction and
        fall back to their original level after the auction.
      • Their limited risk-bearing capacities and inventory management operations are
        seen as key mechanisms driving auction cycles (Beetsma et al.
      • ECB Working Paper Series No 2927

        7

        Second, central bank asset purchases can alleviate the cycle by (partly) absorbing the additional supply
        of substitutable instruments in the secondary market (van Spronsen and Beetsma 2022).

      • This expectation is
        supported by several analyses on the price effects of central bank bond purchases (D?Amico and King 2013;
        Arrata and Nguyen 2017; De Santis and Holm-Hadulla 2020).
      • Empirically, previous research has provided evidence of auction cycles taking place across different jurisdictions.
      • (2016) detect auction cycles for government debt in Italy, but not in Germany, during the European
        sovereign debt crisis.
      • Research on the impact of central bank asset purchases on yield cycles around auctions is still limited.
      • Their paper provides evidence
        that Eurosystem?s asset purchases reduce the presence of auction cycles for euro area government debt.
      • Nonetheless, several questions remain open about auction cycles and unconventional monetary policy
        in the euro area.
      • Therefore, they
        provide only a partial picture of auction cycles and central bank asset purchases in Europe.
      • The use of granular data on central bank asset purchases is especially important in light of the modalities
        of monetary policy implementation of the Eurosystem.
      • Altogether, these elements motivate further investigation of the relationship between central bank asset
        purchases and auction cycles in the euro area.
      • Taken together, these results confirm that Eurosystem?s asset purchases mitigate yield cycles during auction periods and counteract the amplification impact of market volatility.
      • The findings confirm that the flow
        effects of central bank purchases on yield movements around auction dates are driven by lower-rated countries.
      • Additional analyses provide evidence for an indirect effect of purchases on auction cycles and highlight
        the presence of substantial heterogeneity across jurisdictions and purchase programmes.
      • Flow Effects of Central Bank Asset Purchases on Sovereign Bond
        Prices: Evidence from a Natural Experiment.
      • Federico Maria Ferrara
        European Central Bank, Frankfurt am Main, Germany; email: [email protected]

        ? European Central Bank, 2024
        Postal address 60640 Frankfurt am Main, Germany
        Telephone
        +49 69 1344 0
        Website
        www.ecb.europa.eu
        All rights reserved.

    Is home bias biased? New evidence from the investment fund sector

    Retrieved on: 
    Thursday, April 18, 2024
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    Key Points: 

      Spring Capital Successfully Exits Investment in Catenda, a Leader in Construction Project Software

      Retrieved on: 
      Friday, March 15, 2024

      As the lead investor, Spring Capital has sold all its shares in the transaction on a high IRR for itself and co-investors.

      Key Points: 
      • As the lead investor, Spring Capital has sold all its shares in the transaction on a high IRR for itself and co-investors.
      • Founded in 2009 as a spin-off from SINTEF, Catenda is a leader in Building Information Management (BIM) & Common Data Environment (CDE) software.
      • Since Spring Capital’s investment through its Scandinavian investment entity Polaris, Catenda has grown significantly, becoming a trusted partner for construction companies and municipalities seeking innovative solutions for large-scale projects.
      • Construction companies across Europe and Japan have widely adopted the company's software, seeking to streamline operations and improve project outcomes.

      ProjectReady's New Construction Management Software Connects, Syncs, and Manages Construction Project Software Ecosystem

      Retrieved on: 
      Wednesday, February 14, 2024

      WHITE PLAINS, N.Y., Feb. 14, 2024 /PRNewswire/ -- Leading provider of collaborative project information management software for the Architecture, Engineering, and Construction (AEC) industry, ProjectReady, announced it now connects and syncs data, drawings and files between multiple Autodesk Construction Cloud hubs, Procore companies, and SharePoint sites. The new construction management feature, "ReadyConnect," solves challenges that exists when multiple AEC companies on large-scale projects operate their own versions of the same Common Data Environment (CDE) but must collaborate on project information while maintaining the most accurate and current version of project-related content and data.

      Key Points: 
      • Connect, sync, and manage multiple Autodesk Construction Cloud hubs, Procore companies and SharePoint sites.
      • ProjectReady CEO Joe Giegerich said this development gives companies the ability to manage a project's extended software ecosystem.
      • "There's a lot more to project and program management than maintaining a schedule," said Giegerich.
      • "The management and successful delivery of complex construction projects requires architects, engineers, general contractors, subcontractors, and vendors, to eliminate software silos.

      QUEST WATER STRENGTHENS ADVISORY BOARD

      Retrieved on: 
      Wednesday, January 10, 2024

      VANCOUVER, CANADA, Jan. 10, 2024 (GLOBE NEWSWIRE) -- QUEST WATER GLOBAL, INC. (OTC Pink: QWTR) ("Quest" and/or the "Company"), is pleased to announce the expansion of its non-executive Advisory Board (the “Advisory Board”) with the appointment of three new advisors to provide expertise, accelerate growth, and drive impact.

      Key Points: 
      • VANCOUVER, CANADA, Jan. 10, 2024 (GLOBE NEWSWIRE) -- QUEST WATER GLOBAL, INC. (OTC Pink: QWTR) ("Quest" and/or the "Company"), is pleased to announce the expansion of its non-executive Advisory Board (the “Advisory Board”) with the appointment of three new advisors to provide expertise, accelerate growth, and drive impact.
      • Euphresia Luseka is a seasoned water governance expert, social entrepreneur, and programs manager with 14 years of progressive multi-country and multi-donor experience in the Water, Sanitation, and Hygiene (“WASH”) sector in 25 countries.
      • The prestigious Women on Boards Network and Global Water Partnership recently awarded her for championing gender equity in the water sector.
      • These globally recognized leaders each bring a depth of experience and leadership to Quest and will join our current, distinguished Advisory Board members, Derk, Rob, and Craig, to provide a well-rounded, expert panel”, stated John Balanko, CEO of Quest.

      USAID Taps CHAI, GETF to Launch Coalition That Will Test Innovative Approaches to Address Antimicrobial Resistance in Low- and Middle-Income Countries

      Retrieved on: 
      Friday, January 12, 2024

      The new coalition, the Antimicrobial Resistance Access and Stewardship Initiative (AMRASI), is a groundbreaking initiative that will use a sustainable, market-driven approach to address critical gaps in access to diagnostics and antimicrobials while incentivizing their appropriate use in low- and middle-income countries.

      Key Points: 
      • The new coalition, the Antimicrobial Resistance Access and Stewardship Initiative (AMRASI), is a groundbreaking initiative that will use a sustainable, market-driven approach to address critical gaps in access to diagnostics and antimicrobials while incentivizing their appropriate use in low- and middle-income countries.
      • Following a series of convenings to align on these key pilot areas, the coalition aims to mobilize and launch the targeted pilot to test the model in up to two low- and middle-income countries.
      • GETF is serving as the AMRASI Secretariat, supporting the coalition to plan for pilot design in the first half of 2024.
      • "The AMRASI coalition provides a great opportunity to test innovative strategies to combat AMR and develop learnings that can be shared across the sector.

      Bausch + Lomb Reports More Than 76 Million Units of Contact Lenses, Lens Care and Eye Care Materials Collected Through ONE By ONE and Biotrue® Eye Care Recycling Programs

      Retrieved on: 
      Wednesday, November 15, 2023

      Contact lenses, eye care and lens care materials aren’t typically processed in standard recycling facilities due to the small size and the type of plastic used to manufacture them.

      Key Points: 
      • Contact lenses, eye care and lens care materials aren’t typically processed in standard recycling facilities due to the small size and the type of plastic used to manufacture them.
      • “My patients appreciate being able to recycle their used eye health materials through the Bausch + Lomb recycling programs in an environmentally responsible way,” said Jennifer Tsai, O.D., LINE OF SIGHT, New York.
      • In addition to the United States, Bausch + Lomb has a similar contact lens recycling program in Canada called Every Contact Counts.
      • To learn more about the Biotrue Eye Care Recycling program, visit https://www.biotrue.com/terracycle/ .

      AbbaDox Joins Imaging AI in Practice Demonstration at RSNA 2023

      Retrieved on: 
      Thursday, November 16, 2023

      AVENTURA, Fla., Nov. 16, 2023 /PRNewswire/ -- AbbaDox announced today that it will take part in the Imaging Artificial Intelligence in Practice (IAIP) demonstration to be held November 26 – 29 at the 109th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2023), the world's leading annual imaging forum, at McCormick Place in Chicago.

      Key Points: 
      • AVENTURA, Fla., Nov. 16, 2023 /PRNewswire/ -- AbbaDox announced today that it will take part in the Imaging Artificial Intelligence in Practice (IAIP) demonstration to be held November 26 – 29 at the 109th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2023), the world's leading annual imaging forum, at McCormick Place in Chicago.
      • The IAIP demo is a showcase of new AI technologies and integration standards needed to embed AI into the diagnostic radiology workflow.
      • By incorporating AI into its RIS, AbbaDox demonstrates a significant leap in radiology practice, showcasing how AI can streamline referrals, pre-registration, scheduling, intake, dictation and reporting processes within the radiology domain.
      • "Integrating AI into our Radiology Information System is a game changer," said Pierre-Antoine Tricen, Head of Marketing, at AbbaDox.