Optimization

Nearly 40% of U.S. Banks Have Experienced Volatility in their Performance Over the Past Year

Retrieved on: 
Tuesday, May 23, 2023
Consulting, Banking, Professional Services, Finance, Calibuso v. Bank of America Corp., JPMorgan Chase, Financial services, Wells Fargo, Incubation, Research, Bank of America, Citigroup, Growth, Bank, News, Cryptocurrency, Retail, Optimization

This news comes from a new comprehensive business designation study from The ROIG Group, a specialized consultancy firm. The ROIG Group examined 384 U.S.-based publicly traded banks using 2021 and 2022 year-over-year data, including net interest income and non-interest income, efficiency ratio, equity capital, the cost of equity capital, and market value amongst others. ROIG assessed both the historical and future implied performance of each bank in order to classify each bank into one of four designations/states based on the results-- Revive, Optimize, Incubate or Grow.

Key Points: 
  • However, the market believes profits across the all benchmark banks will decline (67%) from current levels.
  • This news comes from a new comprehensive business designation study from The ROIG Group , a specialized consultancy firm.
  • These banks are in the best position to evaluate acquisitions, explore product or service diversification, or pursue customer, channel, or market innovation choices.
  • Revive banks need to focus on fixing what is broken - perhaps even focus on business model reinvention.

Encoded Therapeutics Addresses Common Source of Gene Therapy Toxicity While Achieving Precise Brain Expression in Non-Human Primates, Presented at the American Society of Gene and Cell Therapy 26th Annual Meeting

Retrieved on: 
Friday, May 19, 2023
Science, Neurology, Biotechnology, Research, Pharmaceutical, Health, Genetics, Clinical Trials, Central nervous system, Gene, NGS, Toxicity, Optimization, CNS, Confluence (abstract rewriting), Cell, Annual general meeting, DRG, American Society of Gene and Cell Therapy, NHP, Therapy, Society, Vaccine, Mouse

Encoded Therapeutics announced today the presentation of non-human primate (NHP) validation of the company’s technology to drive desired gene and protein expression patterns at the American Society of Gene and Cell Therapy (ASGCT) 26th Annual Meeting.

Key Points: 
  • Encoded Therapeutics announced today the presentation of non-human primate (NHP) validation of the company’s technology to drive desired gene and protein expression patterns at the American Society of Gene and Cell Therapy (ASGCT) 26th Annual Meeting.
  • An important challenge of developing gene therapy in many central nervous system (CNS) disorders is the toxicity concern associated with high transgene expression in the dorsal root ganglion (DRG).
  • This resulted in a greater than 10-fold selective reduction in DRG transcriptional activity without impacting brain expression.
  • The research team analyzed top candidates in NHPs, showing successful translation to higher species while still achieving precise expression in the CNS.

Owkin Receives European Medicines Agency Letter of Support for Innovative AI-Driven Approach to Oncology Trial Analysis

Retrieved on: 
Tuesday, May 16, 2023
Hepatocellular carcinoma, Mesonet, Deep learning, European Medicines Agency, Survival, Clinical trial, Prognosis, Biomarker, Optimization, EMA, Patient, Mesothelioma, Drug discovery, AI, FDA, Letter, HCC, Dependent and independent variables, Biopsy, Medical device, Pharmaceutical industry

Two Owkin AI models significantly improve the discrimination accuracy for overall survival in hepatocellular carcinoma and mesothelioma.

Key Points: 
  • Two Owkin AI models significantly improve the discrimination accuracy for overall survival in hepatocellular carcinoma and mesothelioma.
  • Therefore, Owkin is encouraged to use their approach in future trials and do additional prospective validation.
  • Felix Balazard, Director of Optimized Development at Owkin said: "This EMA letter of support offers a clear regulatory path for integrating AI models based on histopathology into the analysis of randomized clinical trials.
  • With Owkin's Federated Research Network, it can develop on-demand prognostic scores for other indications, which can further reduce clinical trial failure rates.

Sernova Responds to Dissident Shareholders’ Misleading Statements and Provides Corporate Updates

Retrieved on: 
Thursday, April 6, 2023
TSX Venture Exchange, Telephone, Optimization, Thyroid, HAS, Patient, ILC, Cell, American Diabetes Association, ADA, University, FSE, Dissident, Type 1 diabetes, Research, TSX, IND, Exercise, IPSC, T1D, PSH, Transplant, Thyroidectomy, Glycated hemoglobin, Partnership, Clinical trial, AGM, Hypothyroidism, Immunosuppression, Functional testing, Security (finance), Pharmaceutical industry, Vaccine, Dentistry, Evotec

The two individuals nominated by the dissident shareholder group elected not to participate in the interview process nor did they meet with Sernova’s board.

Key Points: 
  • The two individuals nominated by the dissident shareholder group elected not to participate in the interview process nor did they meet with Sernova’s board.
  • The current board members are well positioned to build on the progress the Company has made to date and take Sernova to its next stage of development as outlined under the Corporate Updates below.
  • The Company is providing the following updates to keep shareholders abreast of developments and work that will create value for shareholders.
  • Sernova shareholders who have any questions or require assistance with voting may contact Sernova’s proxy solicitation agent and shareholder communications advisor:

Saputo Reports Financial Results for the Third Quarter of Fiscal 2023 Ended December 31, 2022

Retrieved on: 
Thursday, February 9, 2023
Conversation, SEDAR, Tax, ID, International, Cheese, Elasticity, Community, Cathedral city, Acceleration, Management, Water, Webcast, Business ethics, Saputo Inc., Food quality, EBITDA, Nutrition, Labour, ESG, Transport, Optimization, Disclosure, Chairperson, Canada, Nature, Growth, Eastern Time Zone, News, Renewable energy, Milk, Cryptocurrency, Risk management, Audit, Environment, Analysis, Safety

These costs will start to be recorded in the fourth quarter of fiscal 2023.

Key Points: 
  • These costs will start to be recorded in the fourth quarter of fiscal 2023.
  • The Board of Directors approved a dividend of $0.18 per share payable on March 17, 2023, to shareholders of record on March 7, 2023.
  • These costs will start to be recorded in the fourth quarter of fiscal 2023.
  • The speakers will be Lino A. Saputo, Chair of the Board, President and Chief Executive Officer, and Maxime Therrien, Chief Financial Officer and Secretary.

Dassault Systèmes and IBM Collaborate to Accelerate the Sustainable Transformation of Asset-intensive Industries Thanks to Virtual Twin Experiences

Retrieved on: 
Thursday, January 19, 2023
Electronic Design Automation, Professional Services, Data Management, Technology, Telecommunications, Software, Finance, Transport, Ecosystem, DSY, Wind, Water supply, Ageing, Optimization, Computing, Marketing, Petrobank Energy and Resources, Cabinet Secretary for Net Zero, Energy and Transport, Environmental Risk Management Authority, Partnership, Environment, 3D, Health, Maintenance, City, Water, Combine, History, Growth, Integration, Engineering, Forecasting, ESG, Workforce, Airport, IBM, Asset management, Dassault Group, Sustainability, Farm, Risk management, Renewable energy, Energy

(Source: IBV 2022 CEO - Energy & Resources insights)

Key Points: 
  • (Source: IBV 2022 CEO - Energy & Resources insights)
    Today companies are confronted with not only rising energy prices but also supply chain and operational disruptions.
  • A company’s ability to harness actionable, data-driven insights is key to accelerate the transformation of assets that are safer, more efficient and more sustainable.
  • To help companies ensure business continuity while achieving their sustainability goals, Dassault Systèmes and IBM have decided to combine Dassault Systèmes’ 3DEXPERIENCE platform and virtual twin experiences with IBM’s solutions for Asset Management, Resources Optimization, Environmental Risk Management and ESG governance.
  • Over the coming months, Dassault Systèmes and IBM will work together to structure the details of their joint offering.

Ordr Publishes Connected Device Security Maturity Model to Guide Healthcare Organizations on the Path to Zero Trust

Retrieved on: 
Tuesday, November 29, 2022
Bell–LaPadula model, Organization, Battery Ventures, Research Institute of Healthcare Organization and Medical Management of Moscow Department of Healthcare, Internet of things, Environment, Internet, Attack, Health care, Multimedia, Machine learning, Risk, FBI, Pragmatism, Optimization, Gartner, Health, Patient, Risk management, NAC, IOT, Resilience, Classification, Connected Devices, Road, Automation, Behavior, Map, Intelligence, Reliability Engineering and Risk Analysis: A Practical Guide, Business, Operational technology, OT, Medical device, Healthcare, Online shopping, Ordre des Administrateurs Agréés du Québec, Northgate Capital

SANTA CLARA, Calif., Nov. 29, 2022 /PRNewswire/ -- Ordr, the leader in connected device security, today published a maturity model aimed at helping healthcare organizations benchmark their connected device security efforts and develop a strategy to improve the efficiency and strength of their security programs.

Key Points: 
  • Comprehensive Guide Details Essential Stages of Connected Device Security, Helping Organizations Improve Cybersecurity Strength and Resiliency
    SANTA CLARA, Calif., Nov. 29, 2022 /PRNewswire/ -- Ordr , the leader in connected device security, todaypublished a maturity model aimed at helping healthcare organizations benchmark their connected device security efforts and develop a strategy to improve the efficiency and strength of their security programs.
  • Ordr published a maturity model to help healthcare organizations benchmark their connected device security efforts.
  • Entitled "A Practical Guide: Implementing Connected Device Security for Healthcare Organizations," the document serves as a framework for healthcare security teams, helping them understand where their organization is on the connected device security maturity curve, and where to focus efforts to make improvements.
  • To learn more about Ordr's connected device security maturity model for healthcare organizations, please sign up for the January 19th Ordr of Business webinar: Healthcare's Guide to Connected Device Security Maturity Model The Road to Zero Trust .

High-Income Millennials Find Big Year-End Tax Deductions And 2-5x Wealth Growth with the OCLAT

Retrieved on: 
Tuesday, November 29, 2022
Royal Bank of Canada, Probate, Report, UHNW, History, FAQ, Bankruptcy, Silicon, CIOS, Optimization, Retirement, Depression, Income tax, CPAS, Baby boomers, Organic, IRAS, Lawyer, IRS, Investment, Tax, Arnold, Research, News, Business, Corporate law, Property, Estate planning, Creative industries, Insurance, Life insurance, Tax advisor, Property management, Millennials, Trust

SCOTTSDALE, Ariz., Nov. 29, 2022 /PRNewswire/ -- Millennials are aggregating more wealth than ever and adopting a peer-reviewed approach known to outperform nearly all other traditional investment vehicles, according to This Strategy Helps Rich Millennials Lower Taxes, Give Back and Build Next-Gen Wealth, a new analysis released by Forbes and Silicon Valley-trained estate planning attorney, Jonathon Morrison.

Key Points: 
  • "The OCLAT is a very powerful tool for building generational wealth" -Larry Lytle, RBC Wealth Management
    "The great wealth transfer has begun!
  • "Wealthy millennials generally are very philanthropic and focus on what their money's impact is on the world," said Hofferber.
  • Specifically:
    The individual funding the OCLAT receives a tax deduction equal to the amount contributed to the OCLAT that year, which provides immediate tax savings.
  • This Strategy Helps Rich Millennials Lower Taxes, Give Back and Build Next-Gen Wealth provides in-depth tax planning findings and recommendations for wealth advisors, CIOs, CPAs, entrepreneurs, and high-income Americans.

Saputo Announces Consolidation Initiatives Aimed at Enhancing Its Operational Efficiency in Australia

Retrieved on: 
Tuesday, November 8, 2022
GLOBE, Forward-looking statement, Nature, Conversation, Drink, Cheese, SAP, Intention, Saputo, Legislation, Efficiency, Dairy, Face, United Kingdom, Management, News, Goal, Company, CDN, Mil-Lel, South Australia, TSX, SEDAR, Saputo Inc., Toronto Stock Exchange, Optimization, Risk management, Facebook

MONTRAL, Nov. 08, 2022 (GLOBE NEWSWIRE) -- Saputo Inc. (we, Saputo or the Company) (TSX: SAP) announces today that it is undertaking further consolidation initiatives intended to enhance its operational efficiency and strengthen its competitiveness in Australia.

Key Points: 
  • MONTRAL, Nov. 08, 2022 (GLOBE NEWSWIRE) -- Saputo Inc. (we, Saputo or the Company) (TSX: SAP) announces today that it is undertaking further consolidation initiatives intended to enhance its operational efficiency and strengthen its competitiveness in Australia.
  • Additionally, while the sites will remain operational, the Company will streamline activities at its facilities located in Leongatha, Victoria, and Mil-Lel, South Australia.
  • Costs related with the consolidation initiatives outlined above will be approximately CDN$26 million after tax, which include non-cash asset write-downs of approximately CDN$20 million after tax.
  • All forward-looking statements included herein speak only as of the date hereof or as of the specific date of such forward-looking statements.

Affluent Medical : Pivotal study progresses to 24 patients successfully implanted with KaliosTM, an adjustable mitral ring that avoids complex re-interventions.

Retrieved on: 
Friday, October 28, 2022
Company, Regulatory News Service, Associate, Medical school, Safety, Congress, Minerva, Dispersive flies optimisation, Department, ISIN, NYHA, Urinary incontinence, Patient, Regurgitation, Surgeon, Degenerative disease, Association, Adrenal insufficiency, Extracorporeal, Heart, Mortality, Optimization, Birth control, Pharmaceutical industry, Medical device, Dentistry, Hospital, Medtech

Affluent Medical : Pivotal study progresses to 24 patients successfully implanted with KaliosTM, an adjustable mitral ring that avoids complex re-interventions.

Key Points: 
  • Affluent Medical : Pivotal study progresses to 24 patients successfully implanted with KaliosTM, an adjustable mitral ring that avoids complex re-interventions.
  • Pivotal study progresses to 24 patients successfully implanted with KaliosTM, an adjustable mitral ring
    Excellent results continue to confirm the efficacy of the KaliosTM adjustable mitral ring in the Optimise II pivotal study.
  • Sustained interest from the surgical community, for the KaliosTM adjustable mitral ring function performed on 5 patients.
  • After adjustment, the results in terms of reduction of mitral regurgitation were excellent with for these 5 patients, namely trivial mitral regurgitation (grade 1+).