Throwing Drug Resistance for a Loop
SAN FRANCISCO, May 12, 2022 /PRNewswire/ --Ā Viruses in the herpesvirus family are leading causes of birth defects, blindness, and failed organ transplants worldwide. Antiviral drugs can combat these viruses, but patients often develop resistance to the drugsārendering them ineffective.
- Antiviral drugs can combat these viruses, but patients often develop resistance to the drugsrendering them ineffective.
- "This study shows, for the first time, that feedback circuits can be a drug target to treat viruses.
- "Antiviral drug resistance is a huge problem that affects millions of people around the world," says Chaturvedi, first author of the new study and research investigator at Gladstone.
- The scientists realized that if they could develop a drug to disrupt this loop, they could potentially treat CMV infection while avoiding drug resistance.