Researchers Discover New Model for "Global" DNA Repair
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Wednesday, March 30, 2022
Cell, Face, New York University Grossman School of Medicine, NYU Langone Health, UvrABC endonuclease, NYU, State Key Laboratories, DNA, Biochemistry, Death, DNA repair, Synthetic biology, Rho, Bacteria, Alfred Noble Prize, GGR, National Natural Science Foundation of China, Pharmacology, Doctor of Philosophy, Ecology, Plant physiology, TCR, Institute of Biophysics, Chinese Academy of Sciences, RNA, National Institutes of Health, Nature Communications, Medicine, Howard Hughes Medical Institute, Genome, Programmer, Technology, National Medal of Technology and Innovation, NIH, National, Institute, Ageing, Mass spectrometry, Gene, Department, Enzyme, Exploratory Science Center, Swiss National Science Foundation, NER, Physiology, Shakne Epshtein, Vaccine, Pharmaceutical industry, Nature, Evgeny Nudler
NEW YORK, March 30, 2022 /PRNewswire/ -- Two studies provide a radically new picture of how bacterial cells continually repair damaged sections (lesions) in their DNA.
Key Points:
- Given that damaged DNA can result in detrimental DNA code changes (mutations) and death, cells evolved to have DNA repair machineries.
- Widely accepted work, including studies that led to a 2015 Noble Prize , had argued that TCR played a relatively small role in repair because it relied on a putative TCR factor that made only a marginal contribution to DNA repair.
- A parallel process, global genome repair (GGR), was assumed to scan and fix most of DNA independent of transcription.
- Both processes were thought to set the stage for nucleotide excision repair (NER), in which a damaged stretch of DNA was snipped out and replaced by an accurate copy.