Sorrento Releases Positive Topline Results from the Phase I Study Completed in Australia and Preliminary Results from a Phase Ib Study in China with STI-1558, an Oral M(pro) Inhibitor as a Standalone Treatment for COVID-19 without the Need for Ritonavir B
There were no severe or serious AEs, no premature discontinuation of STI-1558 due to an AE, and no deaths.
- There were no severe or serious AEs, no premature discontinuation of STI-1558 due to an AE, and no deaths.
- Even the lowest dose produced trough levels significantly above the EC90 value for viral inhibition of STI-1558.
- A similar Phase I/Ib SAD/MAD study has been fully enrolled in China in both healthy subjects and patients infected with SARS-CoV-2.
- The liver enzyme elevations occurred late ( 5 days) in study treatment and resolved without the need for any treatment.