GOF

Praxis Precision Medicines Receives PRIME Designation from the EMA for elsunersen (PRAX-222) for Treatment of SCN2A Gain of Function Developmental Epilepsies

Retrieved on: 
Thursday, November 16, 2023

BOSTON, Nov. 16, 2023 (GLOBE NEWSWIRE) -- Praxis Precision Medicines , Inc. (NASDAQ: PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, today announced that the European Medical Agency (EMA) has awarded its Priority Medicines (PRIME) designation for elsunersen (PRAX-222) for the treatment of SCN2A Gain of Function (GoF) developmental and epileptic encephalopathy (DEE).

Key Points: 
  • BOSTON, Nov. 16, 2023 (GLOBE NEWSWIRE) -- Praxis Precision Medicines , Inc. (NASDAQ: PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, today announced that the European Medical Agency (EMA) has awarded its Priority Medicines (PRIME) designation for elsunersen (PRAX-222) for the treatment of SCN2A Gain of Function (GoF) developmental and epileptic encephalopathy (DEE).
  • The EMA’s PRIME designation provides enhanced development support for priority medicines that target an unmet need and was granted based on the Part 1 data from the EMBRAVE study that showed a reduction in seizures and improvement in seizure free days, as well as preclinical data.
  • “Elsunersen has the potential to significantly impact the lives of patients with SCN2A-DEE and their families,” said Marcio Souza, president and chief executive officer of Praxis.
  • These medicines are considered priority medicines by the EMA, whose aim is to optimize development plans and accelerate evaluations so medicines that address significant unmet medical needs can reach patients faster.

GRIN Therapeutics Announces First Patient Dosed in Phase 1B Clinical Trial with Radiprodil for Treatment of GRIN-related Disorders

Retrieved on: 
Thursday, March 23, 2023

GRIN Therapeutics Inc., a leader in development of therapies to treat GRIN-related disorders, today announced that the first patient has been dosed in the Honeycomb Study, the Company’s Phase 1B clinical trial of radiprodil, an investigational NR2B-negative allosteric modulator in development for the treatment of GRIN-related disorders.

Key Points: 
  • GRIN Therapeutics Inc., a leader in development of therapies to treat GRIN-related disorders, today announced that the first patient has been dosed in the Honeycomb Study, the Company’s Phase 1B clinical trial of radiprodil, an investigational NR2B-negative allosteric modulator in development for the treatment of GRIN-related disorders.
  • Radiprodil targets the hyperactive receptors associated with the development and progression of GRIN-related disorders by potently and selectively modulating the Nmethyl-D-aspartate (NMDA) receptor subtype 2B (NR2B).
  • People living with GRIN-related disorders present with a spectrum of symptoms including epilepsy, behavioral disorders, autism, intellectual disability, and movement disorders.
  • Currently, there are no disease-specific treatment options for GRIN-related disorders.

Crossover Health Shares New Research at ATA 2023 on Virtual PT and Hybrid Care

Retrieved on: 
Friday, March 3, 2023

Crossover Health Medical Group leaders will unveil research results pertaining to areas experiencing limited study: comparing virtual care to in-person care and the value of hybrid care for population health management.

Key Points: 
  • Crossover Health Medical Group leaders will unveil research results pertaining to areas experiencing limited study: comparing virtual care to in-person care and the value of hybrid care for population health management.
  • "The Value of Integrating In-person and Virtual Care for Population Health Management in Employer-Sponsored Primary Care Settings," will be presented by Yvonne Robinson-Hawkins, MD, National Virtual Care Team Physician at Crossover Health.
  • Results found that outcomes improved under a hybrid care model, which offers flexibility and choice in addressing population health needs.
  • Crossover Health has been an industry leader in the delivery of both virtual and onsite care through its unique and highly effective hybrid care approach.

Guggenheim Investments Announces December 2022 Closed-End Fund Distributions

Retrieved on: 
Thursday, December 1, 2022

Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.

Key Points: 
  • Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.
  • Guggenheim Investments is the global asset management and investment advisory division of Guggenheim Partners, LLC (Guggenheim), with over $218 billion* in assets under management across fixed income, equity, and alternative strategies.
  • Guggenheim Investments includes Guggenheim Funds Investment Advisors, LLC (GFIA), Guggenheim Partners Investment Management, LLC (GPIM), Guggenheim Funds Distributors, LLC (GFD) and Guggenheim Partners Advisors, LLC (GPA).
  • Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Partners Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Partners India Management.

Guggenheim Investments Announces November 2022 Closed-End Fund Distributions

Retrieved on: 
Tuesday, November 1, 2022

Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.

Key Points: 
  • Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.
  • Guggenheim Investments is the global asset management and investment advisory division of Guggenheim Partners, LLC (Guggenheim), with over $218 billion* in assets under management across fixed income, equity, and alternative strategies.
  • Guggenheim Investments includes Guggenheim Funds Investment Advisors, LLC (GFIA), Guggenheim Partners Investment Management, LLC (GPIM), Guggenheim Funds Distributors, LLC (GFD) and Guggenheim Partners Advisors, LLC (GPA).
  • Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Partners Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Partners India Management.

Guggenheim Investments Announces October 2022 Closed-End Fund Distributions

Retrieved on: 
Monday, October 3, 2022

Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.

Key Points: 
  • Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.
  • Guggenheim Investments is the global asset management and investment advisory division of Guggenheim Partners, LLC (Guggenheim), with over $228 billion* in assets under management across fixed income, equity, and alternative strategies.
  • Guggenheim Investments includes Guggenheim Funds Investment Advisors, LLC (GFIA), Guggenheim Partners Investment Management, LLC (GPIM), Guggenheim Funds Distributors, LLC (GFD) and Guggenheim Partners Advisors, LLC (GPA).
  • Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Partners Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Partners India Management.

Guggenheim Investments Announces September 2022 Closed-End Fund Distributions

Retrieved on: 
Thursday, September 1, 2022

Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.

Key Points: 
  • Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.
  • Guggenheim Investments is the global asset management and investment advisory division of Guggenheim Partners, LLC (Guggenheim), with over $228 billion* in assets under management across fixed income, equity, and alternative strategies.
  • Guggenheim Investments includes Guggenheim Funds Investment Advisors, LLC (GFIA), Guggenheim Partners Investment Management, LLC (GPIM), Guggenheim Funds Distributors, LLC (GFD) and Guggenheim Partners Advisors, LLC (GPA).
  • Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Partners Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Fund Management (Europe) Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Partners India Management.

Guggenheim Investments Announces August 2022 Closed-End Fund Distributions

Retrieved on: 
Monday, August 1, 2022

Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.

Key Points: 
  • Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.
  • Guggenheim Investments is the global asset management and investment advisory division of Guggenheim Partners, LLC (Guggenheim), with over $228 billion* in assets under management across fixed income, equity, and alternative strategies.
  • Guggenheim Investments includes Guggenheim Funds Investment Advisors, LLC (GFIA), Guggenheim Partners Investment Management, LLC (GPIM), Guggenheim Funds Distributors, LLC (GFD) and Guggenheim Partners Advisors, LLC (GPA).
  • Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Partners Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Fund Management (Europe) Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Partners India Management.

Guggenheim Investments Announces July 2022 Closed-End Fund Distributions

Retrieved on: 
Friday, July 1, 2022

Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.

Key Points: 
  • Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.
  • Guggenheim Investments is the global asset management and investment advisory division of Guggenheim Partners, LLC (Guggenheim), with over $252 billion* in assets under management across fixed income, equity, and alternative strategies.
  • Guggenheim Investments includes Guggenheim Funds Investment Advisors, LLC (GFIA), Guggenheim Partners Investment Management, LLC (GPIM), Guggenheim Funds Distributors, LLC (GFD) and Guggenheim Partners Advisors, LLC (GPA).
  • Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Partners Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Fund Management (Europe) Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Partners India Management.

Guggenheim Investments Announces June 2022 Closed-End Fund Distributions

Retrieved on: 
Wednesday, June 1, 2022

Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.

Key Points: 
  • Distributions may be paid from sources of income other than ordinary income, such as short-term capital gains, long-term capital gains or return of capital.
  • Guggenheim Investments is the global asset management and investment advisory division of Guggenheim Partners, LLC (Guggenheim), with over $252 billion* in assets under management across fixed income, equity, and alternative strategies.
  • Guggenheim Investments includes Guggenheim Funds Investment Advisors, LLC (GFIA), Guggenheim Partners Investment Management, LLC (GPIM), Guggenheim Funds Distributors, LLC (GFD) and Guggenheim Partners Advisors, LLC (GPA).
  • Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Fund Management (Europe) Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Partners India Management.