Synthetic control method

RSNA: Early Coronary Disease, Impaired Heart Function Found in Asymptomatic People with HIV

Retrieved on: 
Thursday, April 4, 2024

OAK BROOK, Ill., April 4, 2024 /PRNewswire-PRWeb/ -- A new study found increased coronary vessel wall thickness that was significantly associated with impaired diastolic function in asymptomatic, middle-aged individuals living with HIV. The study was published today in Radiology: Cardiothoracic Imaging, a journal of the Radiological Society of North America (RSNA).

Key Points: 
  • A new study found increased coronary vessel wall thickness that was significantly associated with impaired diastolic function in asymptomatic, middle-aged individuals living with HIV.
  • The ability to detect early coronary artery disease in persons living with HIV and potentially prevent detrimental effects on the heart muscle is important.
  • This research shows the impact of HIV on developing subtle subclinical coronary artery disease and its effects on heart function.
  • "This research shows the impact of HIV on developing subtle subclinical coronary artery disease and its effects on heart function."

seoClarity Unveils Enhanced SEO Split Tester for Fast Implementation

Retrieved on: 
Monday, March 18, 2024

CHICAGO, March 18, 2024 /PRNewswire/ -- seoClarity, an enterprise leader in AI-driven SEO technology, has enhanced its SEO Split Tester, which validates SEO hypotheses for faster execution and delivers ROI-backed business cases.

Key Points: 
  • CHICAGO, March 18, 2024 /PRNewswire/ -- seoClarity , an enterprise leader in AI-driven SEO technology, has enhanced its SEO Split Tester , which validates SEO hypotheses for faster execution and delivers ROI-backed business cases.
  • Continuing their $30 million investment in SEO innovation, this major enhancement of SEO Split Tester addresses the challenge of limited engineering resources, neverending test ideas, and no real way of assessing ROI to earn buy-in for implementation.
  • "With the expansive possibilities and streamlined approach with SEO Split Tester, SEOs have to ask, 'What wouldn't I test now?'"
  • For more information about SEO Split Tester and the broader ClarityAutomate suite, visit https://www.seoclarity.net/seo-automation/seo-split-testing-tool

BullFrog AI Announces Availability of Fireside Chat Recording Featuring CEOs of BullFrog AI and the Lieber Institute

Retrieved on: 
Friday, March 8, 2024

GAITHERSBURG, Md., March 08, 2024 (GLOBE NEWSWIRE) -- BullFrog AI Holdings, Inc. (NASDAQ: BFRG; BFRGW) ("BullFrog AI" or the "Company"), a technology-enabled drug development company using artificial intelligence (AI) and machine learning to enable the successful development of pharmaceuticals and biologics, today announced the availability of the recording for the recently held fireside chat.

Key Points: 
  • GAITHERSBURG, Md., March 08, 2024 (GLOBE NEWSWIRE) -- BullFrog AI Holdings, Inc. (NASDAQ: BFRG; BFRGW) ("BullFrog AI" or the "Company"), a technology-enabled drug development company using artificial intelligence (AI) and machine learning to enable the successful development of pharmaceuticals and biologics, today announced the availability of the recording for the recently held fireside chat.
  • This enlightening session, hosted by RedChip Companies on March 5, 2024, featured BullFrog AI's CEO, Vin Singh, alongside Daniel R. Weinberger M.D., Director and CEO of the Lieber Institute for Brain Development (LIBD).
  • The recording can be accessed via the following link: https://youtu.be/40rogXtHBJ8
    The fireside chat provided a deep dive into the early findings from the collaboration between BullFrog AI and LIBD.
  • This innovative method has uncovered biological differences and similarities across various brain disorders and has identified potential biological subtypes within individual disorders.

BullFrog AI to Discuss Findings from its Collaboration with Lieber Institute for Brain Development in Fireside Chat Hosted by RedChip

Retrieved on: 
Friday, February 9, 2024

The fireside chat will delve into the early findings from BullFrog AI and LIBD’s collaboration which successfully stratified brain expression data, offering what may turn out to be unprecedented insights into psychiatric conditions.

Key Points: 
  • The fireside chat will delve into the early findings from BullFrog AI and LIBD’s collaboration which successfully stratified brain expression data, offering what may turn out to be unprecedented insights into psychiatric conditions.
  • For the first time, this partnership has enabled the clustering of subjects based on biological data alone, independent of their behavioral diagnoses.
  • This innovative method has uncovered biological differences and similarities across various brain disorders and has identified potential biological subtypes within individual disorders.
  • To participate in the fireside chat, please register at:

Unlearn Raises $50 Million Series C to Optimize Clinical Research With AI-Powered Digital Twin Technology

Retrieved on: 
Thursday, February 8, 2024

Founded in 2017 as an AI research company, Unlearn has always been at the forefront of developing innovative AI-based solutions for clinical trials.

Key Points: 
  • Founded in 2017 as an AI research company, Unlearn has always been at the forefront of developing innovative AI-based solutions for clinical trials.
  • Unlearn’s AI models generate an individual digital twin for every trial participant before they are randomized into the experimental or control arm.
  • “Breaking down these barriers and proving the value of digital twin technology continues to be a main driver for us at Unlearn.
  • “Unlearn is introducing powerful AI models to help make clinical research more streamlined and efficient,” said Pauline Yang, Partner at Altimeter Capital.

Longtime NRA chief Wayne LaPierre is leaving the gun group in trouble but still powerful

Retrieved on: 
Tuesday, January 30, 2024

Wayne LaPierre will resign from the National Rifle Association at the end of January 2024.

Key Points: 
  • Wayne LaPierre will resign from the National Rifle Association at the end of January 2024.
  • During most of the 33 years he spent at its helm as its executive vice president, the gun group’s membership, revenue and clout grew sharply.
  • The group announced his impending departure shortly before the NRA’s civil fraud trial began in New York City.

From defeat to victory

  • He joined the NRA as a state lobbyist after working as a legislative aide to Virginia state Delegate Alfred Victor “Vic” Thomas, a conservative Democrat.
  • Often described as bookish and quiet, LaPierre brought to the NRA his considerable skills as a political strategist.
  • He also developed a pugnacious public persona, memorably calling federal agents “jack-booted government thugs” in a 1995 fundraising letter.

Fighting gun control

  • Though it occasionally celebrated and supported hunting or shooting sports, it increasingly emphasized the importance of firearms for self-defense.
  • With LaPierre at the helm of the NRA, congressional action toward gun control ground to a near halt.
  • LaPierre also led the NRA through a sea change in the prevailing legal interpretation of the Second Amendment as its long effort to enshrine gun ownership as a constitutional right came to fruition.
  • Those rulings have forced states to reassess gun regulations already on their books.

Losing members, waning influence

  • All told, they allegedly misused $64 million of the funds in the NRA’s coffers.
  • The NRA is reportedly hemorrhaging members, a key source of its operating revenue and the heart of its political power.
  • For the moment, it’s still the largest gun advocacy organization, though the spending gap between gun rights and gun control groups continues to narrow.

No permanent replacement yet

  • And yet his influence will remain in the short run, as longtime confidant Andrew Arulanandam will step into his shoes on an interim basis.
  • The NRA’s board will decide on a permanent replacement in May, when the group holds its annual meeting in Dallas.


Cari Babitzke does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Netflix's You Are What You Eat uses a twin study. Here's why studying twins is so important for science

Retrieved on: 
Tuesday, January 16, 2024

A new Netflix documentary, You Are What You Eat, showcases sets of identical twins as they adopt different diets.

Key Points: 
  • A new Netflix documentary, You Are What You Eat, showcases sets of identical twins as they adopt different diets.
  • For eight weeks one twin follows a vegan diet while the other one follows an omnivorous diet.
  • The experiment is compelling because, being genetically identical, the health of each twin is very similar before the trial.

Twins as comparisons for each other

  • The Netflix documentary highlights one important feature of twins – they are good for making comparisons.
  • Identical twins share nearly all of their genes, and usually grow up in the same household, meaning they experience the same parenting, schooling and so on.
  • By focusing on differences between twins, we eliminate genetic and common family factors, and can be more confident about causality.
  • Using twins doesn’t fully solve the problem of omitted factors, but it helps to reduce it.

Twins and heritability

  • Galton’s fascination with twins stemmed from wanting to know why we are the way we are.
  • The main approach is essentially to see whether identical twins, who are genetically the same, are more similar than fraternal twins, who on average share only 50% of the gene variants that make us unique.
  • If the identical twins are more similar, that indicates genes matter.

Limitations and misuse of twin research

  • One drawback to twin studies is that twins are a select group, and findings may not always generalise to the broader population.
  • Twin heritability studies also rely on strong assumptions, like that the common family environment matters to the same extent for identical and fraternal twins.
  • There has also been some misunderstanding and misuse of findings from twin studies.

The future of twin research

  • Twin studies have been conducted for decades, with more than 60 twin registries operating around the world.
  • In Australia, the largest registry is Twins Research Australia, who have around 75,000 members.


Nathan Kettlewell does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Airship Unifies Experimentation and Optimization to Improve Every Mobile Customer Experience

Retrieved on: 
Thursday, November 16, 2023

Nowhere is this more important than in mobile app experience, where value creation opportunities are 3-4X greater than anywhere else.

Key Points: 
  • Nowhere is this more important than in mobile app experience, where value creation opportunities are 3-4X greater than anywhere else.
  • Today, mobile app experience company Airship introduced a host of enhancements to make continuous experimentation and optimization even easier.
  • From optimizing the performance of cross-channel customer journeys to refining messages, campaigns and no-code native app experiences, to testing app user experience and features themselves, all Airship experiments are now centralized in an Experimentation Hub.
  • With Airship’s solution approach we are streamlining creation, experimentation and optimization, giving brands the keys to unlock agile optimization and more quickly achieve their business goals.”

Evolution of AI and Digitization in Precision Pathology and Image Analysis, Upcoming Webinar Hosted by Xtalks

Retrieved on: 
Tuesday, October 31, 2023

TORONTO, Oct. 31, 2023 /PRNewswire-PRWeb/ -- Discover a groundbreaking webinar delving into the advancements in AI and digitization in precision pathology and image analysis applications in the pharmaceutical, chemical and biotech industries.

Key Points: 
  • Attendees will learn about the current status and future directions of digital pathology in chemistry, pharmaceuticals and biotechnology.
  • The featured speakers will discuss the potential of digital pathology in diagnosing common lesions in toxicology studies, leveraging AI to assist pathologists in distinguishing treated animals from control groups.
  • The speakers will share how digital pathology enables reproducible lesion quantification and assessment of morphological changes in tissue lesions, and more.
  • TORONTO, Oct. 31, 2023 /PRNewswire-PRWeb/ -- Discover a groundbreaking webinar delving into the advancements in AI and digitization in precision pathology and image analysis applications in the pharmaceutical, chemical and biotech industries.