Anurag Agrawal (medical scientist)

DNA Repair Discoveries Hold Promise for New Approaches to Cancer Treatment

Retrieved on: 
Wednesday, August 16, 2023
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In cells that cannot repair DNA effectively, changes (mutations) can occur that lead to cancer.

Key Points: 
  • In cells that cannot repair DNA effectively, changes (mutations) can occur that lead to cancer.
  • Most cells rely on a system called homologous recombination or HR, which uses proteins called BRCA1 and BRCA2 for accurate DNA repair.
  • For this reason, identifying patients with "HR-deficient" cancers has become a priority in the field, in part because such cancer cells are vulnerable to targeted therapies that break their DNA.
  • This work was supported by the Starr Cancer Consortium Award I11-005, National Cancer Institute (NCI) 1P50CA247749, and the Burroughs Wellcome Fund Career Award for Medical Scientists.

Renowned Clinician-Scientist Joins Division of Rheumatology at NYU Langone Health

Retrieved on: 
Monday, October 18, 2021
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NEW YORK, Oct. 18, 2021 /PRNewswire/ -- Nationally recognized for his work studying a novel inflammatory disorder known as VEXAS, David B. Beck, MD, PhD , has joined the Division of Rheumatology at NYU Langone.

Key Points: 
  • NEW YORK, Oct. 18, 2021 /PRNewswire/ -- Nationally recognized for his work studying a novel inflammatory disorder known as VEXAS, David B. Beck, MD, PhD , has joined the Division of Rheumatology at NYU Langone.
  • Dr. Beck previously worked as a postdoctoral fellow and clinical scholar at the National Institutes of Health (NIH).
  • At NYU Langone, he has dual appointments as an assistant professor in the Department of Medicine and the Department of Biochemistry and Molecular Pharmacology , and is a member of the Center for Human Genetics and Genomics and the Division of Rheumatology.
  • An alumnus of Brown University, Dr. Beck earned his medical degree and PhD in biochemistry from NYU School of Medicine.

Recycling a Cell's Energy Centers to Ward Off Parkinson's Disease

Retrieved on: 
Friday, August 6, 2021
Gene, Mitochondrion, Cell, University, Running, PINK1, Burroughs Wellcome Fund, UC, University of California, Berkeley, Recycling, Mitophagy, University of California, San Francisco, MD, National, UCSF, Joan, Technology, Communication, Media contacts database, Gladstone Institutes, Disease, Neurodegeneration, Johns Hopkins, Multimedia, Dopamine, Neuron, Doctor of Philosophy, Neurology, National Science Foundation CAREER Awards, Anurag Agrawal (medical scientist), Trust law, Time, Protein, SAN, Parkinson's disease, Science Advances, Mobile phone, Vaccine, Pharmaceutical industry, Wood drying

"It suggests that mitochondrial recycling is critical to maintaining healthy mitochondria, and disruptions to this process can contribute to neurodegeneration."

Key Points: 
  • "It suggests that mitochondrial recycling is critical to maintaining healthy mitochondria, and disruptions to this process can contribute to neurodegeneration."
  • Mutations in these same proteins also cause hereditary forms of Parkinson's disease.
  • Importantly, the study shows that the recycling pathway identified by the scientists requires PINK1 and Parkin, supporting that mitochondrial recycling may also be critical in protecting against neurodegeneration in Parkinson's disease.
  • Gladstone is an independent, nonprofit life science research organization that uses visionary science and technology to overcome disease.