Plasma protein binding

• iNtRON stated that following the proprietary development of the Robot Bacteriophage 2nd generation technology, additional in-vitro evolution technology was applied.
• The Company previously secured the technology to customize and edit bacteriophage genomes as desired using tailored CRISPR/Cas technology and Random Transposon Mutagenesis in 2022.
• Recently, the Company has advanced this technology further to develop a more potent anti-cancer candidate, PHAGERIA®.
• This achievement is significant as it is the first instance of applying in-vitro Evolution technology to ETBF bacteriophages, demonstrating the excellence of the bacteriophage gene editing technology (CRISPR/Cas) and Robotic Bacteriophage improvement platform technology of the Company.

• As interest in psychedelics has grown, so has interest in ways to end a bad trip.
• Recent research reveals that people are giving potentially dangerous advice on social media on how to stop a trip that is less than pleasurable.
• One of the earliest descriptions of a psychedelic experience in western literature can be found in Aldous Huxley’s 1953 book The Doors of Perception.
• Research shows that if someone is in a bad mood or depressed then they are more likely to have a bad trip, as are people who take too high a dose.

Trip killers

• Few clinical studies have examined trip killers, but one has found that ketanserin – a drug used to treat high blood pressure – reverses the psychedelic effects of LSD.
• A recent article in the Emergency Medical Journal analysed posts on Reddit about trip killers.
• Trip killers were discussed most often for LSD (235 posts), magic mushrooms (143 posts) and MDMA (21 posts).

Receptor blocking

• To kill a trip then, one simply has to give the drug user another drug that blocks (rather than activates) the 5-HT2A receptor.
• Many prescription drugs can do this and they tend to be antipsychotic drugs.
• Quetiapine from the list above is one popular example, while another antipsychotic, olanzapine, was mentioned in 14 posts in that study.
• Similarly, the atypical antidepressants trazodone and mirtazapine also block the 5-HT2A receptor.

Colin Davidson has previously received funding from the National Institute on Drug Abuse (NIH, USA) and the European Community for projects related to stimulant drug abuse and novel psychoactive compounds respectively. He is currently a paid consultant with the Defence Science Technology Laboratory (MOD) working on new psychoactive compounds.

• The consumers segment led the global healthcare e-commerce market in 2022.
• The surge in adoption of online healthcare solutions, particularly telemedicine services and health & wellness products, was also accelerated by the COVID-19 pandemic.
• The growth of the global healthcare e-commerce market is propelled by the rising demand for procurement convenience in healthcare, attracting consumers and professionals seeking online access to medicines and medical supplies.
• The United States, with substantial investments in digital healthcare infrastructure and a significant e-commerce industry presence, leads as the largest market for healthcare e-commerce in North America.

• In granting the FTC’s motion for summary judgment, the Federal District Court in the Southern District of Florida also banned Simple Health, five related entities and Dorfman from telemarketing and from marketing, promoting, selling or offering any healthcare products.
• “Simple Health preyed on consumers by selling them bogus health care insurance that cost them thousands of dollars for ‘benefits’ that in fact left consumers unprotected,” said Samuel Levine, Director of the FTC’s Bureau of Consumer Protection.
• The court found that Dorfman and Simple Health, along with Health Benefits One LLC, Health Center Management LLC, Innovative Customer Care LLC, Simple Insurance Leads LLC, and Senior Benefits One LLC violated the FTC Act and the agency’s Telemarketing Sales Rule.
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