Head-twitch response

BetterLife Obtains TD-0148A Behavioural Pharmacology Data Confirming its Projected Non-hallucinogenic Property

Retrieved on: 
Tuesday, November 16, 2021

TD-0148A is a second-generation Lysergic Acid Diethylamide (LSD) derivative molecule that BetterLife believes will mimic the therapeutic potential of LSD without causing psychedelic effects, such as hallucinations.

Key Points: 
  • TD-0148A is a second-generation Lysergic Acid Diethylamide (LSD) derivative molecule that BetterLife believes will mimic the therapeutic potential of LSD without causing psychedelic effects, such as hallucinations.
  • The head-twitch-response (HTR) assay in mice is commonly used to evaluate a compounds hallucinogenic potential in humans.
  • Dr. Halberstadts laboratory is one of the leading research groups focusing on the development of automated HTR assessment methods.
  • "We are pleased to confirm the projected non-hallucinogenic nature of TD-0148A as part of our behavioural pharmacology studies conducted in collaboration with Dr. Halberstadt and his team.

Mindset Pharma Announces Additional Preclinical Results Suggesting Superior Efficacy and Improved Safety in Head-to-Head Comparison to Psilocybin for its First Lead Clinical Candidate, MSP-1014

Retrieved on: 
Wednesday, July 7, 2021

There is a growing body of supporting evidence that suggests MSP-1014 will deliver superior efficacy and an improved safety profile compared to generic psilocybin, said Joseph Araujo, Chief Scientific Officer of Mindset.

Key Points: 
  • There is a growing body of supporting evidence that suggests MSP-1014 will deliver superior efficacy and an improved safety profile compared to generic psilocybin, said Joseph Araujo, Chief Scientific Officer of Mindset.
  • One critical pre-clinical study we used to assess MSP-1014s potential superior efficacy compared to psilocybin was 5-HT2A receptor activity.
  • To assess this activity, we compared MSP-1014 to psilocybin using the mouse head twitch response (HTR) assay.
  • For additional detail on our Family 1 lead candidate MSP-1014, please watch the following interview from Mindsets management team: https://youtu.be/ZWl14TPzAek .