Canals of Hering

Vivet Therapeutics Announces Multiple Projects Update, Including New VTX-803 Preclinical data To Be Presented At 2021 American Society Of Gene And Cell Therapy Annual Meeting

Retrieved on: 
Monday, May 10, 2021
Hepatology, Medical specialties, Anatomy, Bile acid, Cholestasis, Bile, Liver, Progressive familial intrahepatic cholestasis, Canals of Hering

In people with PFIC, liver cells are less able to secrete bile or essential components into the bile.

Key Points: 
  • In people with PFIC, liver cells are less able to secrete bile or essential components into the bile.
  • The disease is estimated to affect one in every 50,000 to 100,000 births in the United States and Europe.
  • Six types of PFIC have been genetically identified, all of which are similarly characterized by impaired bile flow and progressive liver disease.
  • In PFIC3, cholestasis results from the toxicity of bile in which detergent bile salts are not inactivated by phospholipids, leading to bile canaliculi and biliary epithelium injuries.\n'