Dysarthria

• The S1R is highly expressed in the brainstem and spinal cord, areas implicated in ALS and important for bulbar function and speech.
• “We believe it is important for Prilenia to advance our clinical program in ALS, and we are actively planning a single, global, pivotal Phase 3 clinical trial.
• Additional analyses from the same Phase 2 study of participants with definite or probable ALS who were also early and fast progressors were conducted.
• Preliminary topline results in the full analysis set of this Phase 2 study were previously announced.

• Continued drinking causes the slurred speech and loss of balance that is typically associated with being drunk.
• The truth is that alcohol continues to affect the brain and body long after the last drink has been finished.
• Of course, we don't intend to harm anyone when we celebrate during the holiday season.
• Here are some tips to keep in mind if you host a holiday gathering:
  Offer a variety of alcohol-free drinks—water, juices, sparkling sodas.

• Simpson joined senior leaders from Tampa General and the Florida Poison Information Center Tampa, to discuss efforts to prevent unintentional consumption of high-potency THC products.
• TAMPA, Fla., Aug. 16, 2023 /PRNewswire/ -- Tampa General Hospital (TGH) welcomed Florida's Commissioner of Agriculture Wilton Simpson Wednesday to host a roundtable on the risks of unintentional exposure to high-potency THC products and state-level efforts to protect children and Florida consumers.
• "At Tampa General, we offer high-quality care to patients of all ages, from the simplest to the most complex cases.
• "In partnership with Commissioner Simpson, we're working to protect children by raising awareness of the risks associated with these products and ensuring they are properly labeled."

• Many people extend these alcohol-free periods throughout the year by incorporating alcohol-free days into their weekly routines, while still enjoying a drink on the weekends.
• But does drinking the same amount spread over the week versus just on the weekends, make any difference health-wise?

How much is too much?

• Australian alcohol guidelines and the World Health Organization state there is no safe level of alcohol use.
• For adults who do drink, the guidelines recommend a maximum of four drinks in one sitting or ten in a week.

But what about a wine each night?

• Everyone processes alcohol at a different rate depending on age, gender, body shape and size.
• Alcohol destroys the fine balance of the bacteria in the gut microbiome, which has been linked to brain health.
• Read more:
  'I take it with a pinch of salt': why women question health warnings linking alcohol with breast cancer

So, no drinking then?

• This is why alcohol-free days are becoming so popular, to balance health risks while also giving us the chance to enjoy social activities.
• Alcohol-free days can also create a domino effect by encouraging other healthy behaviours like eating more fruits and vegetables, drinking more water, improved sleep patterns and getting up early to exercise.

6 tips for better drinking balance

If you’re looking to incorporate more alcohol-free days into your routine you could try to
Finally, it’s important to know everyone slips up now and then. Practice self-forgiveness if you do have a drink on a planned alcohol-free day and don’t give up.

Read more:
We’re getting really good at making alcohol-free beer and wine. Here’s how it’s done