Mevalonate pathway

Clearmind Medicine CEO Issues Letter to Shareholders

Retrieved on: 
Tuesday, April 9, 2024

Recently, our efforts reached a key inflection point as the Israeli Ministry of Health approved our Phase I/IIa clinical trial for CMND-100 for AUD.

Key Points: 
  • Recently, our efforts reached a key inflection point as the Israeli Ministry of Health approved our Phase I/IIa clinical trial for CMND-100 for AUD.
  • CMND-100, a pioneering MEAI-based (5-methoxy-2-aminoindane) formula, has exhibited encouraging results in pre-clinical studies.
  • Notably, it has shown the ability to disrupt the destructive cycle of binge drinking without inducing hallucinations—a common concern with existing treatments.
  • The journey ahead is filled with potential, and we eagerly anticipate sharing impactful updates with our shareholders."

As a child psychiatrist, I know it’s critical for kindergartens to embrace playful learning

Retrieved on: 
Tuesday, April 9, 2024

Would you like to go back there if you could, if only for a moment?

Key Points: 
  • Would you like to go back there if you could, if only for a moment?
  • Unfortunately, fewer and fewer children are having the opportunity to have experiences like this, which is disturbing for many reasons.
  • Along with many others who work in health, as a child psychiatrist I am deeply concerned about this.

Importance of playful learning


Learning to read does not come naturally. Reading requires developing new neural pathways.
This requires some direct instructions for the development of specific skills, and this can be done through playful learning that need not mean a loss of play. This will depend on:
the kindergarten team (comprised of a teacher and early childhood educator) fully understanding their roles and the new curricula priorities;
the team knowing how to support play-based learning in the classroom, and mapping out how they will combine some direct instruction with rich play- and inquiry-based activities;
the team being sufficiently equipped and resourced. Ideally, this would mean being supported by a literacy coach well-versed in evidence-based learning strategies for supporting children’s emerging literacy and for supporting play.

Read more:
To help children learn how to read in the pandemic, encourage writing messages as part of play

Play is not the opposite of learning

  • Until fairly recently, many people considered play to be the opposite of work and learning, believing play is done when the real work of learning has been finished.
  • But once people know that experiences accompanied by emotional connections are much more memorable, you can organize play in ways that increase the amount of learning.
  • From a health perspective, the absence of play, especially outdoor play, leads to rising obesity rates.

The science of learning


There has been an explosion in the study of the science of learning which asks: how does the brain learn? Kathy Hirsh Pasek, a professor of psychology at Temple University, with her team, is leading scholars in this science of learning. According to their research, learning happens best when:
children are active with “minds on” rather than passively sitting for long periods of time with teacher talking or instructing;
they are engaged;
the information is meaningful;
they are socially interacting;
the learning is “iterative,” meaning information or concepts are repeated in varied contexts, and across subject areas, to help children see new ways to combine smaller parts;
they are having fun.
Crucial to success is this: teachers must see that a shift towards playful learning is essential for achieving both engagement and academic success. Principals need to be on board and supportive of this approach.

Teacher-guided play

  • Teachers need to understand the different types of play as described and researched by child development professor Angela Pyle.
  • As her work outlines, play is considered to be on a continuum from free play to guided play to formal games.

Protecting the loss of childhood

  • British education advocate Sir Ken Robinson famously said that felons in jail have more outdoor play time daily than children on average across the globe spend outside playing.
  • Research from other countries has also documented how an increasing sense of business in children’s lives has also crowded out play.
  • There is nothing more basic than the right to belong and the right to play.


Jean Clinton does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Bioelectronic medicine Feinstein Institutes researchers elected to AIMBE College of Fellows

Retrieved on: 
Monday, March 25, 2024

The American Institute for Medical and Biological Engineering (AIMBE) has announced the election of two researchers from The Feinstein Institutes for Medical Research to the AIMBE College of Fellows Class of 2024 for their contributions to the fields of medical and biological engineering, and particularly the field of bioelectronic medicine.

Key Points: 
  • The American Institute for Medical and Biological Engineering (AIMBE) has announced the election of two researchers from The Feinstein Institutes for Medical Research to the AIMBE College of Fellows Class of 2024 for their contributions to the fields of medical and biological engineering, and particularly the field of bioelectronic medicine.
  • Valentin Pavlov, PhD , and Sangeeta Chavan, PhD , both professors in the Institute of Bioelectronic Medicine , were recognized in-person during the AIMBE Annual Event in Washington D.C..
  • Sangeeta Chavan (left) and Valentin Pavlov (right) have been elected to the AIMBE College of Fellows for advancing the fields of medical and biological engineering.
  • On behalf of the Feinstein Institutes and Northwell Health, we congratulate them.”
    The Feinstein Institutes for Medical Research is the global scientific home of bioelectronic medicine where medical researchers use modern technology to develop new device-based therapies to treat disease and injury.

Health Direct Introduces AminoMind, The First-Of-Its-Kind Nootropic Collagen

Retrieved on: 
Thursday, March 14, 2024

IRVINE, Calif., March 14, 2024 /PRNewswire/ -- Health Direct, makers of AminoSculpt Liquid Collagen, has released the first-ever nootropic collagen, AminoMind. This new form of liquid collagen contains the clinically documented dosage of Brain-derived Neurotropic Factor (BDNF) building nutrients. BDNF creates new brain cells (neurogenesis) and supports new neural pathways and adaptation (neuroplasticity.)

Key Points: 
  • IRVINE, Calif., March 14, 2024 /PRNewswire/ -- Health Direct, makers of AminoSculpt Liquid Collagen, has released the first-ever nootropic collagen, AminoMind.
  • This new form of liquid collagen contains the clinically documented dosage of Brain-derived Neurotropic Factor (BDNF) building nutrients.
  • CollaBrain's dipeptides are the only collagen clinically shown to improve brain health and support BDNF production.
  • It's about supporting your brain's structure," says Jim Caras, founder of Health Direct, "Imagine pouring very expensive water into a bucket with holes.

As the Popularity of Children-Focused Companies Rise, Kids 'R' Kids Celebrates 39 Years and 170 Franchise Locations

Retrieved on: 
Thursday, February 22, 2024

Kids 'R' Kids Acknowledged as a Top Franchise Opportunity in Billion-Dollar Childcare and Early Education Industry

Key Points: 
  • "Kids 'R' Kids is our opportunity to support our industry's needs with a strong and structured educational program," he says.
  • The Kids 'R' Kids STEAM AHEAD program incorporates Science, Technology, Engineering, Art, and Math into children's daily learning, through play.
  • The Learning Academies provide BRAIN WAVES activities every day, with an emphasis on one of the brain's four lobes on their own.
  • As the nation's priority on early education rises, Kids 'R' Kids looks forward to continued development and expansion of its 170 locations in 2024 and beyond.

Alamar Biosciences Announces the Commercial Launch of Ultra-high Sensitivity NULISAseq™ CNS Disease Panel 120 and NULISAqpcr™ pTau-217 Assays

Retrieved on: 
Tuesday, March 5, 2024

FREMONT, Calif., March 5, 2024 /PRNewswire/ -- Alamar Biosciences, a company powering precision proteomics to enable the earliest detection of disease, announced today the commercial launch of the NULISAseq CNS Disease Panel 120 for highly multiplexed protein analysis of all the critical pathways implicated in major neurological disorders, and the NULISAqpcr pTau-217 Assay (ALZpath antibody) for focused studies of this important biomarker in dementia research. Both assays benefit from the unparalleled sensitivity of the NULISA™ chemistry and are run on the fully automated ARGO™ HT System that streamlines the time to complete large cohort studies. The launch of these two products represents another important milestone in the company's goal to deliver high-sensitivity protein analysis from biofluids to enable earlier diagnosis of disease and better prediction of therapeutic outcomes. The products are expected to ship in Q2 2024. 

Key Points: 
  • Data demonstrating the superior performance over existing assays highlighted at the Alzheimer's Disease and Parkinson's Disease (AD/PD™ 2024) international conference in Lisbon, Portugal.
  • Both assays benefit from the unparalleled sensitivity of the NULISA™ chemistry and are run on the fully automated ARGO™ HT System that streamlines the time to complete large cohort studies.
  • The Alamar products represent a significant advancement in Alzheimer's Disease research, says Dr. Henrik Zetterberg.
  • This research depends on the availability of biomarkers to detect disease earlier and distinguish between highly related dementia disorders.

Alamar Biosciences Announces the Commercial Launch of Ultra-high Sensitivity NULISAseq™ CNS Disease Panel 120 and NULISAqpcr™ pTau-217 Assays

Retrieved on: 
Tuesday, March 5, 2024

FREMONT, Calif., March 5, 2024 /PRNewswire/ -- Alamar Biosciences, a company powering precision proteomics to enable the earliest detection of disease, announced today the commercial launch of the NULISAseq CNS Disease Panel 120 for highly multiplexed protein analysis of all the critical pathways implicated in major neurological disorders, and the NULISAqpcr pTau-217 Assay (ALZpath antibody) for focused studies of this important biomarker in dementia research. Both assays benefit from the unparalleled sensitivity of the NULISA™ chemistry and are run on the fully automated ARGO™ HT System that streamlines the time to complete large cohort studies. The launch of these two products represents another important milestone in the company's goal to deliver high-sensitivity protein analysis from biofluids to enable earlier diagnosis of disease and better prediction of therapeutic outcomes. The products are expected to ship in Q2 2024. 

Key Points: 
  • Data demonstrating the superior performance over existing assays highlighted at the Alzheimer's Disease and Parkinson's Disease (AD/PD™ 2024) international conference in Lisbon, Portugal.
  • Both assays benefit from the unparalleled sensitivity of the NULISA™ chemistry and are run on the fully automated ARGO™ HT System that streamlines the time to complete large cohort studies.
  • We have also partnered with ALZpath, Inc. to bring the performance of their industry standard pTau217 antibody to a new level of sensitivity."
  • This research depends on the availability of biomarkers to detect disease earlier and distinguish between highly related dementia disorders.

'An Urgent Public Health Necessity' - National Institute for Play Releases New Report Underlining Science and Power of Play

Retrieved on: 
Thursday, February 29, 2024

The free report, entitled The Power of Play: Losing and Finding Ourselves through Everyday Play, advances the understanding that play is proven to lead to healthier, happier lives.

Key Points: 
  • The free report, entitled The Power of Play: Losing and Finding Ourselves through Everyday Play, advances the understanding that play is proven to lead to healthier, happier lives.
  • Its authors, Scott G. Eberle, Ph.D., and Stuart Brown, M.D., have spent decades studying the impact of play on the human condition.
  • It collectively asserts that the diminishing presence of play in our daily lives is an urgent public health matter.
  • Ancient in its origins, play is core to the human experience and is engrained in all of us.

'An Urgent Public Health Necessity' - National Institute for Play Releases New Report Underlining Science and Power of Play

Retrieved on: 
Thursday, February 29, 2024

The free report, entitled The Power of Play: Losing and Finding Ourselves through Everyday Play, advances the understanding that play is proven to lead to healthier, happier lives.

Key Points: 
  • The free report, entitled The Power of Play: Losing and Finding Ourselves through Everyday Play, advances the understanding that play is proven to lead to healthier, happier lives.
  • Its authors, Scott G. Eberle, Ph.D., and Stuart Brown, M.D., have spent decades studying the impact of play on the human condition.
  • It collectively asserts that the diminishing presence of play in our daily lives is an urgent public health matter.
  • The report was produced by NIFP with support by Visit California and contributors Anthony Christopher, Lauren Sundstrom, Bowen F. White, and Tom Norquist.

Bacteria in your gut can improve your mood − new research in mice tries to zero in on the crucial strains

Retrieved on: 
Thursday, February 15, 2024

But can they improve your mood, too?

Key Points: 
  • But can they improve your mood, too?
  • But the short answer, according to my team’s recently published research, is likely yes.
  • The beneficial bacteria in probiotics become part of a community of other microscopic organisms living in your digestive system called the gut microbiome.

Studying mood in mice

  • So how do you measure the mood of mice?
  • We exposed them to poop from either stressed mice or normal mice by sprinkling soiled bedding in their enclosures.
  • Microbes from the donor mice started to populate the gut microbiomes of the clean mice.
  • Within a few weeks, the clean mice exposed to poop from stressed mice started to develop stress- and anxiety-like behavior, even though nothing else had changed.

Which bacteria affect mood?

  • The results of our experiments led us back to our original question: Which bacteria can change your mood?
  • In our analysis, we found that a group of bacteria called Lactobacillus was greatly reduced in the stressed mice.
  • So we had to come up with a way to test how different strains affect anxious behavior.
  • Instead of tackling this colossal task alone, we created a method that other microbiome scientists can also use to look at this group of bacteria as systematically as possible.
  • To recreate the same experimental conditions for each species of microbe, we created a group of mice with only six species of bacteria in their microbiome, the bare minimum needed for normal and healthy development, which did not include Lactobacillus.

What’s next?

  • We hope that our research will open avenues for other scientists to test different probiotics.
  • In the meantime, give the Lactobacillus in your gut some love through a healthy, probiotics-rich diet.


Andrea Merchak has received funding from the National Institutes of Health (T32 NS115657, F31 AI174782).