Collagen receptor

NGM Discloses Third Oncology Development Candidate, NGM438, a Novel Antagonist Antibody Inhibiting LAIR1 for the Treatment of Advanced Solid Tumors

Retrieved on: 
Wednesday, December 9, 2020
Immunoglobulin superfamily, Clusters of differentiation, Branches of biology, LAIR1, Cell biology, LILRB1, LILRB2, Stromal cell, LAIR2, Collagen receptor

LAIR1 is a collagen-binding inhibitory receptor expressed on immune cells1-2 that is implicated in immune suppression.

Key Points: 
  • LAIR1 is a collagen-binding inhibitory receptor expressed on immune cells1-2 that is implicated in immune suppression.
  • LAIR1 and collagens are upregulated in multiple cancer types3-7 where collagens are produced by activated stromal cells.
  • Designed to inhibit LAIR1 interactions with stromal-derived collagens, NGM438 has the potential to block this stromal checkpoint and restore anti-tumor immune responses.
  • NGM707 is a novel dual antagonist antibody that inhibits Immunoglobulin-like transcript 2 (ILT2) and Immunoglobulin-like transcript 4 (ILT4).