Brainstem

• In a groundbreaking development for brain tumor care in Poland, the Neurosurgery Centre at N. Copernicus Hospital in Gdansk is thrilled to announce the imminent installation of the ZAP-X® Gyroscopic Radiosurgery® platform.
• Completed in five or less brief outpatient visits, patients often resume their normal activities on the same day as treatment.
• Historically, N. Copernicus Hospital lacked stereotactic radiosurgery capabilities, forcing patients to travel to other centers, often requiring substantial travel distances.
• The Neurosurgery Centre at N. Copernicus Hospital looks forward to the positive impact the ZAP-X Gyroscopic Radiosurgery platform will have on advancing neurosurgical care and providing cutting-edge treatment options for patients in the region.

• Connective tissue is found throughout the human body, within and between structures as varied as muscles, nerves and internal organs.
• Many people, especially young women, have very flexible connective tissue.
• Hypermobile connective tissue can also cause serious health problems throughout the body, including the gut, nerves, skin, urinary tract and even immune system.

Wide range of symptoms

• While some forms have genetic markers, more than 90% of hypermobility conditions – including hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder – do not.
• Symptoms and severity can differ greatly from person to person and vary over time.
• Symptoms can include widespread pain and frequent injury, irritable bowel syndrome, indigestion, hernias, frequent bruising and poor skin healing, trouble breathing, migraines and headaches, dizziness, fatigue, insomnia, anxiety and trouble concentrating.
• Hypermobility experts now believe Ehlers-Danlos syndrome is not as rare as previously thought – and many people are misdiagnosed or undiagnosed.

Difficulties with diagnosis

• Lack of a diagnosis can be frightening and discouraging for people with hypermobility spectrum disorder.
• Patients are often told nothing is wrong with them and they are just complaining too much or have low pain tolerance.
• A delayed diagnosis leads to worse function, increased pain and disability.

How physical therapy can help hypermobility

• Although research is limited, existing research suggests that physical therapy can improve sensory awareness and motor control – and help patients identify, activate and strengthen stabilizing muscles.
• Occupational therapy can also benefit hypermobile patients through environmental modifications, activity pacing and assistive and mobility devices like splints, braces and wheelchairs.
• Once it has been identified, though, many strategies can help decrease pain and injuries – and improve function and quality of life.

• NMOSD is most notably associated with acute attacks, which can cause irreversible damage to the optic nerve, spinal cord, brain and brain stem.
• Disease management goals are focused on prevention of attacks, as well as understanding and tracking biomarkers that could signal these attacks.
• The strong link suggests that higher sNfL levels may be associated with more severe attacks and increased risk of residual disability.
• Compared with placebo, UPLIZNA was shown to hinder biomarker elevation during attacks while reducing biomarker levels over time in the absence of attacks.

• LYNNWOOD, Wash., March 15, 2023 /PRNewswire/ -- Today, Kurve Therapeutics (Kurve Tx) announced it has filed for new intellectual property on its nose-to-brain technology platform.
• Kurve's technology uses the neuronal pathway rather than the circulatory system, which means the drug is delivered to the extracellular space in the brain.
• This means there is the opportunity to move the drug once it reaches the brain.
• In contrast, the circulatory system traps the drug in the blood vessels blocking the opportunity to move the drug to a desired target.