BioNTech Expands Late-Stage Clinical Oncology Portfolio with Initiation of further Phase 2 Trial with mRNA-based Individualized Neoantigen Specific Immunotherapy in New Cancer Indication
Neoantigens are proteins that are produced by cancer cells that differ from the proteins produced by healthy cells.
- Neoantigens are proteins that are produced by cancer cells that differ from the proteins produced by healthy cells.
- The trial will be conducted at various sites in the United States, followed by Europe and Asia Pacific region.
- The recent Phase 1 study has shown that individualized neoantigen vaccination is feasible for this tumor type with low mutational burden and an immunosuppressive microenvironment3.
- The Phase 2 trial of autogene cevumeran in patients with PDAC is the third later-stage trial based on BioNTech’s individualized cancer vaccine platform iNeST.