Recurrence

• Much of Australia is drought-prone, and the risk is expected to increase as global warming continues.
• That’s why it’s important for Australia to be prepared for droughts, particularly those lasting multiple years.
• If we add in human-caused climate change, it suggests future droughts will be far worse than we imagined.

Rainfall records aren’t enough

• But in Australia these records only go back to around the year 1900.
• This doesn’t fully record the huge range of natural rainfall variability over many hundreds of years.
• To a degree, we can get these long records from features of the environment such as trees, which record information about rainfall changes in their annual growth rings.
• First, we looked at the characteristics of Australian droughts due to natural fluctuations in rainfall.

Our results

• This change is consistent with the rainfall trends expected in these regions in future due to human-caused climate change.
• It suggests that an emerging human influence on our climate has already made southern parts of Australia more drought-prone.
• In other words, human-caused climate change had probably not yet caused Australian droughts to be any drier, or changed how often we are in drought.

How bad could Australian droughts be?

• That is far longer than any drought that has been experienced in Australia since instrumental records began.
• This includes the Murray-Darling Basin where typical droughts last century lasted four to five years.

Mega-droughts are possible in Australia

• This new research shows mega-droughts in Australia are possible – even without the influence of climate change.
• This finding is supported by evidence drawn from ice cores, which suggests a 39-year drought gripped eastern Australia around 800 years ago.
• This is concerning, because climate change is also increasing the chance of reduced rainfall across much of southern Australia.

Georgina Falster receives funding from the Australian Research Council, through the Centre of Excellence for Climate Extremes. Nerilie Abram receives funding from the Australian Research Council through the Centre of Excellence for Climate Extremes, the Centre of Excellence for 21st Century Weather, the Australian Centre for Excellence in Antarctic Science, and a Discovery Project Nicky Wright receives funding from the Australian Research Council and industry sources.

• Additionally, the Company has appointed Renovi!’s CEO, David Burns, Ph.D., to its Advisory Board to guide its entry into this multi-billion dollar market, assist on mergers and acquisitions including a potential combination of Renovi!
• The availability of the newest medical technologies and the cheaper cost of treatment in emerging nations are key market drivers enhancing market growth.
• reinvents traditional outpatient rehabilitation by offering patients a “recovery vacation” at an upscale, beachfront medical resort with healthy diet, exercise, community and exceptional medical care.
• The Dominican Republic is uniquely positioned as a medical tourism destination because of its low costs, proximity to the U.S., a well-established tourism infrastructure, and tax incentives for tourism investments.

• The twelve patients treated for locoregionally recurrent head and neck squamous cell carcinoma previously received chemoradiation alone (42%), surgery (58%) or surgery combined with radiation or chemoradiation (92%).
• The data were presented in a poster at the 2024 Multidisciplinary Head and Neck Cancers Symposium held February 29-March 2, 2024, in Phoenix, AZ.
• Complete remission was achieved in 64% of patients, with an ORR of 73% (n=11).
• Observed adverse events were consistent with the known toxicity profile of iopofosine I 131, with cytopenias being the most common with all patients recovering.

• Total revenue for the fourth quarter of 2023 was $83.4 million, compared to $61.9 million for the fourth quarter of 2022.
• Total operating expenses for the fourth quarter of 2023 were $83.3 million, compared to $55.8 million for the fourth quarter of 2022.
• Net income for the fourth quarter of 2023 was $25.2 million, compared to net income of $4.5 million for the fourth quarter of 2022.
• Kiniksa will host a conference call and webcast at 8:30 a.m. Eastern Time on Wednesday, February 28, 2024, to discuss fourth quarter and full-year 2023 financial results and recent portfolio execution.