Severe acute respiratory syndrome coronavirus

Bio-Techne's RNAscope™ Technology Aids in the Retrospective Tissue Diagnosis of COVID-19 in cases with no previous testing for SARS-CoV-2

Retrieved on: 
Wednesday, August 4, 2021
Sarbecovirus, Zoonoses, Respiratory diseases, Viruses, Bat virome, Severe acute respiratory syndrome, Severe acute respiratory syndrome coronavirus, COVID-19

RNAscope enables detection of RNA transcripts while retaining cellular morphology, allowing researchers to localize SARS-CoV-2 RNA directly in the tissues, including in the hyaline membranes, pneumocytes and macrophages of lung, and epithelial cells of airways.

Key Points: 
  • RNAscope enables detection of RNA transcripts while retaining cellular morphology, allowing researchers to localize SARS-CoV-2 RNA directly in the tissues, including in the hyaline membranes, pneumocytes and macrophages of lung, and epithelial cells of airways.
  • The SARS-CoV-2 ASR will provide researchers and pathologists with a powerful technology for the detection of SARS-CoV-2 in fixed tissues.
  • During the pandemic, RNAscope probes have been an essential tool in elucidating the pathology of this devastating virus in over one hundred COVID-19 publications to date."
  • Bhatnagar J, Gary J, Reagan-Steiner S, Estetter LB, Tong S, et al.

Innovation Pharmaceuticals Provides Update on Brilacidin Antiviral Research

Retrieved on: 
Monday, August 2, 2021
Coronaviridae, Sarbecovirus, Zoonoses, Severe acute respiratory syndrome coronavirus 2, Brilacidin, Variants of SARS-CoV-2, Severe acute respiratory syndrome coronavirus, COVID-19, Antiviral drug, Severe acute respiratory syndrome

WAKEFIELD, Mass., Aug. 02, 2021 (GLOBE NEWSWIRE) -- Innovation Pharmaceuticals (OTCQB:IPIX) (the Company), a clinical stage biopharmaceutical company, today provided an update on ongoing antiviral research of Brilacidin, the Companys defensin-mimetic drug candidate being developed for treatment of COVID-19 under FDA Fast Track designation, by different groups of scientists.

Key Points: 
  • WAKEFIELD, Mass., Aug. 02, 2021 (GLOBE NEWSWIRE) -- Innovation Pharmaceuticals (OTCQB:IPIX) (the Company), a clinical stage biopharmaceutical company, today provided an update on ongoing antiviral research of Brilacidin, the Companys defensin-mimetic drug candidate being developed for treatment of COVID-19 under FDA Fast Track designation, by different groups of scientists.
  • Brilacidin SARS-CoV-2 Manuscript: Scientists conducting laboratory testing of Brilacidin, in particular its ability to block entry of SARS-CoV-2 into human cells, have submitted their research findings for peer-review publication.
  • These data include insights into Brilacidins antiviral mechanisms of action and Brilacidin activity against the Alpha (B.1.1.7) and Gamma (P.1) SARS-CoV-2 variants.
  • Taken together, the results from ongoing lab research into Brilacidins antiviral properties by different groups of scientists only strengthens our belief in Brilacidin, said Leo Ehrlich, Chief Executive Officer at Innovation Pharmaceuticals.

Augmenta Bioworks and TFF Pharmaceuticals Announce Positive In Vitro Data Demonstrating Binding and Neutralization of the SARS-CoV-2 Delta Variant by Lead Anti-COVID-19 Antibody, AUG-3387

Retrieved on: 
Thursday, July 29, 2021
Coronaviridae, Sarbecovirus, Zoonoses, Variants of SARS-CoV-2, COVID-19 pandemic in India, SARS-CoV-2 Delta variant, COVID-19, Variant, Delta, Severe acute respiratory syndrome coronavirus 2, Severe acute respiratory syndrome coronavirus, Severe acute respiratory syndrome

MENLO PARK, Calif. and AUSTIN, Texas, July 29, 2021 (GLOBE NEWSWIRE) -- Augmenta Bioworks, a biotechnology company enabling breakthroughs in medicine through immune profiling, and TFF Pharmaceuticals, Inc. (NASDAQ: TFFP), a clinical-stage biopharmaceutical company focused on developing and commercializing innovative drug products based on its patented Thin Film Freezing (TFF) technology platform, today announced positive in vitro data indicating that their lead anti-COVID-19 monoclonal antibody (“mAb”) therapy, AUG-3387, binds to and neutralizes the SARS-CoV-2 Delta variant (B.1.617.2). The Delta variant is the current dominant strain of SARS-CoV-2 in the U.S., Europe and other geographic regions around the world.

Key Points: 
  • The Delta variant is the current dominant strain of SARS-CoV-2 in the U.S., Europe and other geographic regions around the world.
  • The Delta variant now accounts for 83% of new cases in the U.S., according to recent CDC data.
  • Demonstration that AUG-3387 effectively neutralizes the Delta variant in vitro is an encouraging step towards developing the therapy to slow and prevent ongoing spread of COVID-19.
  • Those forward-looking statements involve known and unknown risks, uncertainties and other factors that could cause actual results to differ materially.

COVID-19 Associated With Long-Term Cognitive Dysfunction, Acceleration Of Alzheimer's Symptoms

Retrieved on: 
Thursday, July 29, 2021
Coronaviridae, Sarbecovirus, Cognitive disorders, Learning disabilities, Psychiatric diagnosis, Dementia, Alzheimer's disease, COVID-19, Severe acute respiratory syndrome coronavirus, Severe acute respiratory syndrome, Long Covid, Impact of COVID-19 on neurological, psychological and other mental health outcomes

New research reported at the Alzheimer's Association International Conference (AAIC) 2021 , held virtually and in Denver found associations between COVID-19 and persistent cognitive deficits, including the acceleration of Alzheimer's disease pathology and symptoms.

Key Points: 
  • New research reported at the Alzheimer's Association International Conference (AAIC) 2021 , held virtually and in Denver found associations between COVID-19 and persistent cognitive deficits, including the acceleration of Alzheimer's disease pathology and symptoms.
  • Of the patients, 158 were positive for SARS-CoV-2 with neurological symptoms and 152 were positive for SARS-CoV-2 without neurologic symptoms.
  • "These findings suggest that patients who had COVID-19 may have an acceleration of Alzheimer's-related symptoms and pathology," said Wisniewski.
  • Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina.

COVID-19 Associated With Long-Term Cognitive Dysfunction, Acceleration Of Alzheimer's Symptoms

Retrieved on: 
Thursday, July 29, 2021
Coronaviridae, Sarbecovirus, Cognitive disorders, Learning disabilities, Psychiatric diagnosis, Dementia, Alzheimer's disease, COVID-19, Severe acute respiratory syndrome coronavirus, Severe acute respiratory syndrome, Long Covid, Impact of COVID-19 on neurological, psychological and other mental health outcomes

New research reported at the Alzheimer's Association International Conference (AAIC) 2021 , held virtually and in Denver found associations between COVID-19 and persistent cognitive deficits, including the acceleration of Alzheimer's disease pathology and symptoms.

Key Points: 
  • New research reported at the Alzheimer's Association International Conference (AAIC) 2021 , held virtually and in Denver found associations between COVID-19 and persistent cognitive deficits, including the acceleration of Alzheimer's disease pathology and symptoms.
  • Of the patients, 158 were positive for SARS-CoV-2 with neurological symptoms and 152 were positive for SARS-CoV-2 without neurologic symptoms.
  • "These findings suggest that patients who had COVID-19 may have an acceleration of Alzheimer's-related symptoms and pathology," said Wisniewski.
  • Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina.

New Publications Confirm Paragon Genomics CleanPlex® SARS-CoV-2 Panel Enables Accurate Identification of Variants of Concern

Retrieved on: 
Wednesday, July 28, 2021
Coronaviridae, Variants of SARS-CoV-2, Sarbecovirus, COVID-19 pandemic in India, COVID-19, SARS-CoV-2 lineage B.1.617, Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2 Alpha variant, SARS-CoV-2 Delta variant, Severe acute respiratory syndrome coronavirus, COVID-20

The analyses enabled the researchers to assign the viral genomes to SARS-CoV-2 lineages and confirm the presence of the B.1.1.7 variant.

Key Points: 
  • The analyses enabled the researchers to assign the viral genomes to SARS-CoV-2 lineages and confirm the presence of the B.1.1.7 variant.
  • A third study, from a Paragon Genomics public health laboratory customer, describes how the CleanPlex SARS-CoV-2 Panel enabled the early identification of one of the first confirmed cases of the B.1.617.2 Delta variant in Brazil.
  • Paragon Genomics' CleanPlex SARS-CoV-2 technology has powered variant detection and tracking since the virus first appeared.
  • In March 2020, the company launched the CleanPlex SARS-CoV-2 Panel whole genome SARS-CoV-2 sequencing on Illumina and MGI Tech sequencing platforms.

DiosCURE Announces Exclusive Worldwide License Agreement for Best-in-Class Nanobodies Against COVID-19

Retrieved on: 
Wednesday, July 28, 2021
Health, Infectious diseases, Clinical trials, Research, Science, Pharmaceutical, Biotechnology, Immunology, Single-domain antibody, Dios, Antibody, Severe acute respiratory syndrome coronavirus, Branches of biology, Biology, Health

Under the terms of the agreement, DiosCURE is the exclusive, worldwide licensor for the lead drug candidates DIOS-202, DIOS-203 and DIOS-301 and has prioritized access to all future candidates resulting from the research collaboration.

Key Points: 
  • Under the terms of the agreement, DiosCURE is the exclusive, worldwide licensor for the lead drug candidates DIOS-202, DIOS-203 and DIOS-301 and has prioritized access to all future candidates resulting from the research collaboration.
  • DIOS-202, DIOS-203 and DIOS-301 are multivalent single-chain antibodies with unique molecular modes-of-action to inactivate SARS-CoV-2 virions.
  • The Companys lead candidates, DIOS-202, DIOS-203 and DIOS-301, are synergistic combinations of single-domain antibodies derived from camelid heavy chain-only antibodies.
  • As the IP Service Provider of the University of Bonn, PROvendis GmbH negotiated the commercialization contract with DiosCURE.

iXensor Levels Up PixoTest Covid-19 Ag Test With The Launch Of PixoHealth Data Management Platform As The Security Solution For The New Normalcy

Retrieved on: 
Tuesday, July 27, 2021
Medicine, Branches of biology, Medical terminology, Medical tests, Health sciences, Point-of-care testing, COVID-19, Glucose meter, Web portal, Severe acute respiratory syndrome coronavirus

In addition, the PixoHealth Pass Admin Web Portal synchronizes multi-source COVID-19 related health data and rapid test results from PixoHealth Pass App users and PixoTest POCT Analyzer simultaneously.

Key Points: 
  • In addition, the PixoHealth Pass Admin Web Portal synchronizes multi-source COVID-19 related health data and rapid test results from PixoHealth Pass App users and PixoTest POCT Analyzer simultaneously.
  • The utilization of PixoHealth Pass Admin Web Portal, PixoTest POCT Analyzer and PixoHealth Pass App fully digitizes the data management processes with a one-time setup.
  • In addition, PixoHealth Pass Admin App allows organizations to configure health-data based access management rules for keeping SARS-CoV-2 from causing cluster infections.
  • In 2017, iXensor introduced the PixoTest Blood Glucose Monitoring System as the world's first US FDA-approved smartphone camera-based blood test.

SpeeDx Launch Solution for SARS-CoV-2 Variant Analysis

Retrieved on: 
Monday, July 26, 2021
Health, Infectious diseases, Clinical trials, Research, Science, Biotechnology, Coronaviridae, Sarbecovirus, Zoonoses, Variants of SARS-CoV-2, Variant of concern, Molecular diagnostics, Severe acute respiratory syndrome coronavirus 2, Severe acute respiratory syndrome coronavirus, DiaSorin

Ltd., a developer of innovative molecular diagnostic solutions, have launched a new product line of research reagents to support reflex variant analysis for circulating SARS-CoV-2 variants of concern (VOC).

Key Points: 
  • Ltd., a developer of innovative molecular diagnostic solutions, have launched a new product line of research reagents to support reflex variant analysis for circulating SARS-CoV-2 variants of concern (VOC).
  • Founded in 2009, SpeeDx is an Australian-based private company with subsidiary offices in Austin and London, and distributors across Europe.
  • SpeeDx specializes in molecular diagnostic solutions that go beyond simple detection to offer comprehensive information for improved patient management.
  • For more information on SpeeDx please see: https://plexpcr.com
    SARS-CoV-2 Variant Classifications and Definitions.

Twist Bioscience Now Shipping Synthetic RNA Positive Controls for Delta (B.1.617.2) SARS-CoV-2 Variant for Development of Accurate Diagnostic Tests

Retrieved on: 
Thursday, July 22, 2021
Research, Medical Supplies, Infectious diseases, FDA, Clinical trials, Biotechnology, Health, Pharmaceutical, Science, Branches of biology, Biology, Natural sciences, Molecular biology, Biotechnology, Laboratory techniques, Sarbecovirus, Zoonoses, Reverse transcription polymerase chain reaction, Severe acute respiratory syndrome coronavirus 2, Severe acute respiratory syndrome coronavirus, COVID-19

Rates of vaccinations in many countries have slowed, with COVID cases specific to the Delta variant spiking.

Key Points: 
  • Rates of vaccinations in many countries have slowed, with COVID cases specific to the Delta variant spiking.
  • In March 2020, Twist launched its first synthetic SARS-CoV-2 RNA distinct reference sequences as positive controls for the development of both next-generation sequencing (NGS) and reverse transcription-polymerase chain reaction (RT-PCR) assays to test for SARS-CoV-2.
  • The Twist synthetic controls are designed based on specific SARS-CoV-2 variants, cover the full viral genome and are sequence-verified.
  • For customers interested in alternative variants of SARS-CoV-2, or synthetic RNA or DNA controls for other sequences, Twist can provide custom controls in multiple formats.