Acute tubular necrosis

ILIAS Biologics Inc. demonstrated the therapeutic effect of anti-inflammatory exosomes for ischemia-reperfusion-induced acute kidney injury

Retrieved on: 
Monday, June 28, 2021
Medical specialties, Kidney diseases, Anatomy, Organs anatomy), Organ failure, Nephrology, Medical emergencies, Acute kidney injury, Acute tubular necrosis, Glomerulonephritis, Ischemia, Kidney disease

It is characterized as a rapid decline in kidney function,and multiple conditions such as acute tubular necrosis and interstitial nephritiscan cause AKI.

Key Points: 
  • It is characterized as a rapid decline in kidney function,and multiple conditions such as acute tubular necrosis and interstitial nephritiscan cause AKI.
  • "Therapeutic exosomes with EXPLOR technology have successfully demonstrated itstherapeutic potential in preclinical models representing multipledisease settings, including sepsis, preterm birth, and AKI.
  • Acute Kidney Injury (AKI) is defined as a rapid dysfunction in kidney function and structure, which results from secondary injury caused by multiple conditions such as acute tubular necrosis, glomerulonephritis, vasculitis, ischemia, and drug-induced nephrotoxicity.
  • [i]Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group (2012) KDIGO clinical practice guideline for acute kidney injury.

COVID-19 Kidney Biopsy Research Shows Mostly Tubular Damage With No Presence of Virus in the Tissue

Retrieved on: 
Friday, July 17, 2020
Health, Infectious diseases, Hospitals, Other Science, General Health, Research, Science, Medical specialties, Medicine, Clinical medicine, Nephrology, Kidney diseases, Renal biopsy, Biopsy, Kidney, Acute tubular necrosis, Pathology, Acute kidney injury, Renal ultrasonography

The biopsies showed no presence of the virus within the kidney tissue.

Key Points: 
  • The biopsies showed no presence of the virus within the kidney tissue.
  • View the full release here: https://www.businesswire.com/news/home/20200717005523/en/
    Biopsy image showing acute tubular necrosis in a kidney.
  • The kidney biopsy samples revealed the presence of ATN, some with other pathological findings, but no evidence of the virus in the kidney tissue itself.
  • Since kidney injury has been observed in COVID-19 patients, the question of direct viral infection of the kidney has been debated by the medical research community.