Gwas

Hackensack Meridian CDI Scientists Uncover Signposts in DNA that Pinpoint Risks for Cancers and other Diseases

Retrieved on: 
Monday, June 29, 2020
Medical specialties, Branches of biology, Genetic epidemiology, Medicine, Genome-wide association study, Gwas, Sjögren syndrome

"Cancer cells are gangsters, but in our approach we make them work for us in a useful way," said Benjamin Tycko, M.D., Ph.D., the CDI lab director who oversaw the study.

Key Points: 
  • "Cancer cells are gangsters, but in our approach we make them work for us in a useful way," said Benjamin Tycko, M.D., Ph.D., the CDI lab director who oversaw the study.
  • The current study generated one of the largest high-quality datasets used in this kind of approach.
  • The scientists identified a total of 15,112 allele-specific methylation sites including 1,838 sites located near statistical signals of disease susceptibility from genome-wide association studies (GWAS).
  • These data have been made publicly available so that other scientists can test new hypotheses in "post-GWAS" studies.

COVID-19: LifeDNA and University of Hawai'i Collaborate on Studying Why Certain Populations Are Hit Harder

Retrieved on: 
Tuesday, April 7, 2020
Branches of biology, Genetics, Genetic epidemiology, Genome-wide association study, Epidemiology, Genetic association, ABO, Biology, Gwas, Statistical genetics

"COVID-19 has upended daily life for citizens around the globe," said Cyril Moukarzel, CEO of LifeDNA, Inc. "Based on genetics, certain individuals and populations may be impacted more severely.

Key Points: 
  • "COVID-19 has upended daily life for citizens around the globe," said Cyril Moukarzel, CEO of LifeDNA, Inc. "Based on genetics, certain individuals and populations may be impacted more severely.
  • LifeDNA's scientists are working tirelessly to add to the body of knowledge regarding the effect of these genetic variations."
  • Honolulu-based LifeDNA is collaborating with molecular epidemiologist Maarit Tiirikainen, Ph.D., Associate Professor at the University of Hawai'i at Mnoa.
  • "Epidemiological studiesso-called Genome Wide Association Studies (GWAS)indicate that populations carry different variants of the ACE2 gene.