Murine respirovirus

Mersana Therapeutics to Present Three Posters at Upcoming Virtual 2021 American Association for Cancer Research Annual Meeting

Retrieved on: 
Wednesday, March 10, 2021
Medical specialties, Branches of biology, Antiviral drugs, Cytokines, Immune system, Immunology, Clinical medicine, Interferon, Cytokine, Stimulator of interferon genes, Murine respirovirus, Cancer immunotherapy

These results demonstrate the importance of DAR-ranging studies to identify the optimal ADC for a given target.

Key Points: 
  • These results demonstrate the importance of DAR-ranging studies to identify the optimal ADC for a given target.
  • XMT-2056 was well-tolerated in non-human primates at significantly higher exposure levels than those required for anti-tumor activity in mice and exhibited favorable pharmacokinetics after repeat doses.
  • Data presented in this study demonstrate that cancer cells activate a Type III interferon response downstream of STING pathway activation.
  • Blocking Type III IFNs with neutralizing antibodies in cancer cell:immune cell co-cultures inhibits the production of key cytokines and cancer cell killing induced by STING-agonist ADC treatment.

Therapeutic Solutions International Reports Regression of Glioma, Lung Cancer and Colorectal Cancer using StemVacs in Animal Models

Retrieved on: 
Monday, January 25, 2021
Branches of biology, Virotherapy, Clinical medicine, Medicine, Brachyury, Embryology, Immunotherapy, Lewis lung carcinoma, Cancer immunotherapy, Murine respirovirus

In a series of laboratory experiments, StemVacs administration was demonstrated to induce regression of GL261 glioma, CT-26 colorectal cancer, and Lewis Lung Carcinoma tumors grown in mice.

Key Points: 
  • In a series of laboratory experiments, StemVacs administration was demonstrated to induce regression of GL261 glioma, CT-26 colorectal cancer, and Lewis Lung Carcinoma tumors grown in mice.
  • Last week the Company reported that StemVacs administration effectively reduces breast cancer through immune stimulation in a natural killer cell dependent manner1.
  • Mechanistically, regression in glioma, colorectal and lung cancer was also dependent on mice possessing a functional natural killer cells repertoire.
  • Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases.

What do the Pfizer Vaccine and BetterLife Pharma have in common?

Retrieved on: 
Wednesday, November 18, 2020
Medical specialties, Medicine, Branches of biology, Antivirals, Cytokines, Infectious diseases, Interferon, Virus, Vaccine, Murine respirovirus, Interferon type II

This IFN response ishighly important as some intelligent viruses have evolved to have specific genes that block this IFN response.

Key Points: 
  • This IFN response ishighly important as some intelligent viruses have evolved to have specific genes that block this IFN response.
  • The importance of IFN response has also been reflected in the development of the Pfizer vaccine.
  • The vaccine stimulates the production of IFN gamma in T Cells (responsible for fighting infections).
  • For every vaccine or drug that targets a specific aspect of a virus, viruses mutate and become drug resistant.

BetterLife Pharma (OTCQB:BETRF) Looks to Immune Response Drug Interferon a2b as Potential Therapeutic for COVID-19

Retrieved on: 
Friday, June 19, 2020
Antivirals, Cytokines, Branches of biology, Interferon, Medical specialties, Virus, Biology, IRF3, Murine respirovirus

Not only did IFN a2b help patients' immune systems clear thecoronavirusfaster, it also seemed to reduce certain inflammatory proteins linked to severe COVID-19 complications.

Key Points: 
  • Not only did IFN a2b help patients' immune systems clear thecoronavirusfaster, it also seemed to reduce certain inflammatory proteins linked to severe COVID-19 complications.
  • Scientists have discovered the pandemic-causingcoronavirus is unique in short-circuiting the safest way our immune system kills off a virus, which could have implications for treating COVID-19 with interferon.
  • Interferon describes a family of proteins produced by the body's immune system in response to an invading viral infection.
  • The potential therapeutic approach of interferon gained scientific backing last month when a study published in the journal Cell showed a "striking" feature of coronavirus infection.

5 Questions with a Virus Expert on COVID-19

Retrieved on: 
Friday, March 27, 2020
Medical specialties, Viruses, Medicine, Vaccines, Vaccine, Interferon, Severe acute respiratory syndrome-related coronavirus, Antiviral drug, Hepatitis C vaccine, Murine respirovirus

Being a new virus that has never circulated in humans before means that vaccine research essentially started when the virus was identified in December 2019.

Key Points: 
  • Being a new virus that has never circulated in humans before means that vaccine research essentially started when the virus was identified in December 2019.
  • Simply put, until it was identified, there was no virus to design a vaccine against.
  • Also, the original SARS-CoV emerged in 2003, and generating a vaccine to that virus has proven to be challenging.
  • These responses include inflammation, inducing cell death to destroy both the cell and the virus, and activating antiviral proteins such as interferon.