Cytopathic effect

Polyphor's Balixafortide Demonstrates Consistent Dual Action Anti-Viral and Anti-Inflammatory Activity in COVID-19 Preclinical Trials

Retrieved on: 
Tuesday, June 1, 2021
Sarbecovirus, Zoonoses, Medical specialties, Animal diseases, Bat virome, COVID-19, Occupational safety and health, Public health, Severe acute respiratory syndrome coronavirus 2, Cytopathic effect, Severe acute respiratory syndrome coronavirus, Viral disease

Results from this Phase III trial are expected for objective response rate (ORR) end of Q2 and for progression free survival (PFS) in Q4 2021.

Key Points: 
  • Results from this Phase III trial are expected for objective response rate (ORR) end of Q2 and for progression free survival (PFS) in Q4 2021.
  • In a preclinical experiment using a CPE (cytopathic effect assay), balixafortide demonstrated strong and robust activity against SARS-CoV-2 (COVID-19) infection at clinically relevant concentrations with no adverse cytotoxic effects.
  • In an in vivo hamster animal model, balixafortide showed positive and statistically significant reduction of viral load of SARS COV-2.
  • Balixafortide also reduced COVID19-relevant inflammation markers in the lung including ISG15 gene expression, a key player of respiratory failure in viral infections.

LI-COR Near-Infrared Assays and Technology Offer Insight to Coronavirus Researchers

Retrieved on: 
Tuesday, July 7, 2020
Viruses, Zoonoses, Natural sciences, Laboratory techniques, Microbiology, Virology, Cytopathic effect, Severe acute respiratory syndrome-related coronavirus, Assay, LI-COR Biosciences, Severe acute respiratory syndrome

Key to this process are quantifiable assays that provide robust data for all aspects of research.

Key Points: 
  • Key to this process are quantifiable assays that provide robust data for all aspects of research.
  • LI-CORBiosciences continues to support virology researchers with products, tools, and services to better understand SARS-CoV-2 and other viruses.
  • Traditionally, infectivity of viruses that exhibit cytopathic effect (CPE) has been characterized using plaque assays.
  • From academic discovery through preclinical validation, whether characterizing a pathway or validating a therapeutic candidate, LI-COR technology helps move research through the development process.

CytoSMART to Donate 100 Live-cell Imaging Systems to Assist COVID-19 Researchers

Retrieved on: 
Wednesday, April 22, 2020
Health, Articles, Cytopathic effect, Virology, Isolation, Laboratory

Labs working to combatCOVID-19will benefit from this initiative,as CytoSMARTaims to reduce the huge workload currently facing researchers on projects vital to controlling the disease.

Key Points: 
  • Labs working to combatCOVID-19will benefit from this initiative,as CytoSMARTaims to reduce the huge workload currently facing researchers on projects vital to controlling the disease.
  • "We aim to do our part to assist researchers in minimizing the time they have to spend in high-contamination labs, by providing them with remote video access to evaluate the status of their cell cultures.
  • The video data is used to remotely monitor the cytopathic effect, this way researchers know when it's the right time to harvest the virus."
  • According to guidelines by the CDC and the WHO, isolation and characterization of COVID-19 should be performed in BSL-3 laboratories.

CytoSMART to Donate 100 Live-cell Imaging Systems to Assist COVID-19 Researchers

Retrieved on: 
Wednesday, April 22, 2020
Health, Articles, Cytopathic effect, Virology, Isolation, Laboratory

Labs working to combatCOVID-19will benefit from this initiative,as CytoSMARTaims to reduce the huge workload currently facing researchers on projects vital to controlling the disease.

Key Points: 
  • Labs working to combatCOVID-19will benefit from this initiative,as CytoSMARTaims to reduce the huge workload currently facing researchers on projects vital to controlling the disease.
  • "We aim to do our part to assist researchers in minimizing the time they have to spend in high-contamination labs, by providing them with remote video access to evaluate the status of their cell cultures.
  • The video data is used to remotely monitor the cytopathic effect, this way researchers know when it's the right time to harvest the virus."
  • According to guidelines by the CDC and the WHO, isolation and characterization of COVID-19 should be performed in BSL-3 laboratories.

Measuring Cytopathic Effects of Viral Infections by Applied BioPhysics Inc.

Retrieved on: 
Wednesday, March 25, 2020
Virology, Cytopathic effect, Virus, Electrical impedance

TROY, N.Y., March 25, 2020 /PRNewswire-PRWeb/ -- Measuring Cytopathic Effects of Viral Infections by Applied BioPhysics Inc.

Key Points: 
  • TROY, N.Y., March 25, 2020 /PRNewswire-PRWeb/ -- Measuring Cytopathic Effects of Viral Infections by Applied BioPhysics Inc.
    Cytopathic effects of viral infections upon cultured cells are difficult to quantify due to the subjective nature of monitoring cell morphology.
  • Applied Biophysics provides instruments and specialized 96 well microplates to detect virus-induced morphological changes quantitatively and in real-time using an impedance-based electrical measurement.
  • Cells are seeded and grown to confluence upon gold electrodes located on the base of each well of the microplate.
  • Following the latent period associated with the infection, one begins to see changes in the impedance associated with viral-induced cytopathic activities.