LV

Attralus Announces Publication of Two Studies Evaluating Iodine (124I) Evuzamitide (AT-01) using PET/CT in the Journal of American College of Cardiology (JACC CV Imaging)

Retrieved on: 
Tuesday, November 7, 2023

124I-evuzamitide may be more sensitive than standard diagnostics, with cardiac uptake shown in ATTR patients who had negative 99mTc-PYP scans.

Key Points: 
  • 124I-evuzamitide may be more sensitive than standard diagnostics, with cardiac uptake shown in ATTR patients who had negative 99mTc-PYP scans.
  • The manuscripts from Brigham and Women’s Hospital (BWH) and from the University of Tennessee Graduate School of Medicine were published in the Journal of American College of Cardiology – Cardiovascular Imaging (JACC CV Imaging).
  • The manuscripts, entitled “Cardiac Amyloid Quantification Using 124I-Evuzamitide (124I-P5+14) Versus 18F-Florbetapir” and “Cardiac Amyloid Detection by PET/CT Imaging of Iodine (124I) Evuzamitide (124I-p5+14): A Phase 1/2 Study,” have been published online.
  • These studies suggest that 124I-evuzamitide is a promising novel radiotracer to detect and quantify cardiac amyloid in multiple types of amyloidosis.

Rocket Pharmaceuticals Reports Third Quarter 2023 Financial Results and Highlights Recent Progress

Retrieved on: 
Monday, November 6, 2023

Supported peer-reviewed expert consensus paper to increase awareness of diagnosis and clinical management of patients with Danon Disease.

Key Points: 
  • Supported peer-reviewed expert consensus paper to increase awareness of diagnosis and clinical management of patients with Danon Disease.
  • Highlights of the publication include a review of diagnosing Danon Disease emphasizing the importance of genetic testing upon clinical suspicion, natural history, management recommendations and recent advances in potential gene therapy treatment.
  • Rocket is working towards initiation of Phase 2 pivotal trial activities in Europe and the UK.
  • As of September 30, 2023, Rocket had cash, cash equivalents and investments of $437.2 million.

Latest news - Next CULT Committee meetings on 27-28 November - Committee on Culture and Education

Retrieved on: 
Thursday, October 26, 2023

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    Next CULT Committee meetings on 27-28 November
    Next CULT Committee meetings on 27-28 November
    25-10-2023 - 09:47
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GoodWe Expands Utility Portfolio Capacity with Launch of 320/350kW String Inverter, Lowering LCOE

Retrieved on: 
Tuesday, October 10, 2023

With this addition, GoodWe strengthens its utility portfolio by providing increased capacity and significantly reducing Levelized Cost of Energy (LCOE).

Key Points: 
  • With this addition, GoodWe strengthens its utility portfolio by providing increased capacity and significantly reducing Levelized Cost of Energy (LCOE).
  • The series offers options of 12 MPPTs and 15 MPPTs and boasts a maximum efficiency of 99.01%.
  • With a maximum string input current of 15/20A, it is compatible with bifacial modules, optimizing energy yields for power plants.
  • Looking forward, GoodWe remains committed to advancing technological innovation, bringing a more bankable product portfolio and turnkey solutions for large-scale solar projects."

GoodWe Expands Utility Portfolio Capacity with Launch of 320/350kW String Inverter, Lowering LCOE

Retrieved on: 
Tuesday, October 10, 2023

With this addition, GoodWe strengthens its utility portfolio by providing increased capacity and significantly reducing Levelized Cost of Energy (LCOE).

Key Points: 
  • With this addition, GoodWe strengthens its utility portfolio by providing increased capacity and significantly reducing Levelized Cost of Energy (LCOE).
  • The series offers options of 12 MPPTs and 15 MPPTs and boasts a maximum efficiency of 99.01%.
  • With a maximum string input current of 15/20A, it is compatible with bifacial modules, optimizing energy yields for power plants.
  • Looking forward, GoodWe remains committed to advancing technological innovation, bringing a more bankable product portfolio and turnkey solutions for large-scale solar projects."

Attralus Announces Presentation of Clinical Data for 124I-Evuzamitide (AT-01), a Novel Amyloid-Specific PET Imaging Agent, at the 28th Annual Scientific Session of the American Society of Nuclear Cardiology

Retrieved on: 
Monday, October 2, 2023

Attralus-Sponsored Test-Retest repeatability study demonstrates excellent repeatability and supports the potential use of AT-01 imaging to monitor disease progression in patients with cardiac amyloidosis.

Key Points: 
  • Attralus-Sponsored Test-Retest repeatability study demonstrates excellent repeatability and supports the potential use of AT-01 imaging to monitor disease progression in patients with cardiac amyloidosis.
  • AT-01 uptake in cardiac amyloidosis shows moderate and statistically significant correlations with traditional measures of cardiac structure and function.
  • These data were included in oral and poster presentations at the 28th Annual Scientific Session of the American Society of Nuclear Cardiology (ASNC) taking place September 29-October 1, 2023, in Toronto, Canada.
  • These findings support the potential use of this novel imaging agent to monitor disease progression in patients with cardiac amyloidosis.

NecstGen and ProteoNic report development of improved viral vectors through the application of premium 2G UNic™ technology

Retrieved on: 
Tuesday, September 19, 2023

LEIDEN, the Netherlands, Sept. 19, 2023 /PRNewswire/ -- Necstgen, a non-profit CDMO and ProteoNic, a leading provider of premium vector technology and services for efficient production of biologics, announce the successful development of improved lentiviral (LV) vectors, driving higher titers of functional viral particles based on the application of ProteoNic's 2G UNic™ premium vector technology.

Key Points: 
  • LEIDEN, the Netherlands, Sept. 19, 2023 /PRNewswire/ -- Necstgen, a non-profit CDMO and ProteoNic, a leading provider of premium vector technology and services for efficient production of biologics, announce the successful development of improved lentiviral (LV) vectors, driving higher titers of functional viral particles based on the application of ProteoNic's 2G UNic™ premium vector technology.
  • Both companies, located on the Leiden Bio Science Park, recognise the need to increase viral titres and optimise production processes.
  • We will continue our efforts aimed at improving AAV and LV vectors, catering to both transient production systems and stable viral producer cell lines".
  • ProteoNic will offer licensing and co-development opportunities, while NecstGen plans to apply the technology in its CDMO business.

NecstGen and ProteoNic report development of improved viral vectors through the application of premium 2G UNic™ technology

Retrieved on: 
Tuesday, September 19, 2023

LEIDEN, the Netherlands, Sept. 19, 2023 /PRNewswire/ -- Necstgen, a non-profit CDMO and ProteoNic, a leading provider of premium vector technology and services for efficient production of biologics, announce the successful development of improved lentiviral (LV) vectors, driving higher titers of functional viral particles based on the application of ProteoNic's 2G UNic™ premium vector technology.

Key Points: 
  • LEIDEN, the Netherlands, Sept. 19, 2023 /PRNewswire/ -- Necstgen, a non-profit CDMO and ProteoNic, a leading provider of premium vector technology and services for efficient production of biologics, announce the successful development of improved lentiviral (LV) vectors, driving higher titers of functional viral particles based on the application of ProteoNic's 2G UNic™ premium vector technology.
  • Both companies, located on the Leiden Bio Science Park, recognise the need to increase viral titres and optimise production processes.
  • We will continue our efforts aimed at improving AAV and LV vectors, catering to both transient production systems and stable viral producer cell lines".
  • ProteoNic will offer licensing and co-development opportunities, while NecstGen plans to apply the technology in its CDMO business.

Rocket Pharmaceuticals Reaches FDA Alignment on Pivotal Phase 2 Trial Design for RP-A501 in Danon Disease

Retrieved on: 
Tuesday, September 12, 2023

The disease affects an estimated 15,000 to 30,000 patients in the U.S. and Europe.

Key Points: 
  • The disease affects an estimated 15,000 to 30,000 patients in the U.S. and Europe.
  • A global natural history study will serve as an external comparator and run concurrently to the Phase 2 pivotal trial.
  • In-house manufacturing has been completed with sufficient high-quality drug product produced to fully supply the Phase 2 pivotal study.
  • Additionally, Rocket has secured an ICD-10 code from CMS for LAMP2 deficiency in Danon Disease

4th Generation Lentiviral Vectors: An Improved Gene Delivery System, Upcoming Webinar Hosted by Xtalks

Retrieved on: 
Wednesday, September 13, 2023

TORONTO, Sept. 13, 2023 /PRNewswire-PRWeb/ -- Lentiviral vectors remain the go-to choice for the efficient delivery of large therapeutic genes to patient cells. In addition to ex vivo indications, the development of lentiviral vectors for in vivo applications is being re-invigorated through more specific targeting. Yet, improvements in both production scale and product quality are needed to realize this. Moreover, the architecture and features of lentiviral vectors used in the clinic have not changed significantly over the last two decades, and so their limitations, such as packaging size limit, or transgene-specific impacts on titer, may impede the success of therapeutic development, therefore increasing the need for 4th generation lentiviral vectors.

Key Points: 
  • Attendees will also learn about solutions for developing high-titer stable producer cell lines and considerations when embarking on LV gene therapy to maximize success.
  • TORONTO, Sept. 13, 2023 /PRNewswire-PRWeb/ -- Lentiviral vectors remain the go-to choice for the efficient delivery of large therapeutic genes to patient cells.
  • In addition to ex vivo indications, the development of lentiviral vectors for in vivo applications is being re-invigorated through more specific targeting.
  • These 4th generation lentiviral vectors have the potential to streamline complex manufacturing processes, enhance productivity and open possibilities for developing new treatments.