Fragrance ingredient exposure is orders of magnitude below thresholds of concern, study shows
MAHWAH, N.J., Feb. 6, 2024 /PRNewswire/ -- The Research Institute for Fragrance Materials, Inc. (RIFM), in collaboration with scientific modeling, data analytics, and computing company Creme Global, compared the fragrance exposure of the highest-end product users to the Threshold of Toxicological Concern (TTC) and Dermal Sensitization Threshold (DST) to determine a realistic understanding of consumer exposure to fragrance. The TTC is based on the U.S. Food and Drug Administration's Threshold of Regulation, which it expands upon to include consideration of an ingredient's molecular structure in conjunction with its toxicity data. The TTC approach is internationally recognized by regulators including the European Food Safety Authority (EFSA).
- The TTC approach is internationally recognized by regulators including the European Food Safety Authority (EFSA) .
- The study authors compared exposure to the approximately 3,000 in-use fragrance-producing ingredients to their respective TTCs and DSTs.
- Representative fragrance ingredients were randomly selected and analyzed for exposure distribution by product type (i.e., personal, household, oral, and air care) and route of exposure.
- Exposure calculations were performed by the Creme-RIFM Aggregate Exposure model, which provides realistic exposure estimates that consider all fragrances the population is exposed to across all products used.