Apeiron | Jotup

GT Apeiron Announces Development Candidate Nomination of Brain Penetrant PRMT5 Inhibitor, GTA182, for the Potential Treatment of MTAP-Deleted Solid Cancers

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Tuesday, October 17, 2023

SAN FRANCISCO and SHANGHAI, China, Oct. 17, 2023 (GLOBE NEWSWIRE) -- GT Apeiron Therapeutics (‘Apeiron’), a biopharmaceutical company harnessing the power of artificial intelligence to develop targeted precision therapies for unmet medical needs, today announced the development candidate nomination of GTA182, a brain penetrant protein arginine methyltransferase 5 (PRMT5) inhibitor that exhibits methylthioadenosine (MTA) cooperativity resulting in high selectivity for MTAP-deleted cancer cells while sparing MTAP-expressing non-cancer cells. This selectivity is expected to provide a more effective and safer treatment option for patients with MTAP-deleted cancers.

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This selectivity is expected to provide a more effective and safer treatment option for patients with MTAP-deleted cancers.
GTA182 is brain penetrant and has demonstrated tumor growth inhibition and tumor regression in in vivo pre-clinical models of glioblastoma (GBM) as well as non-CNS murine cancer models with MTAP deletions.
Apeiron plans to file an Investigational New Drug (IND) application in mid-2024.
"The nomination of our wholly–owned GTA182 program as a candidate for clinical development represents another significant milestone for Apeiron and our commitment to developing innovative therapies for cancer patients with unmet medical needs," said Mingxi Li, Ph.D., Chief Executive Officer of Apeiron.

Apeiron Bioenergy Raises S$50 million through an Investment Grade Green Bond, the First Bioenergy-Focused SGD Bond Issuance in Asia

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Monday, June 26, 2023

HSBC, Capital market, Asian Development Bank, SAF, UCO, Aviation, Export Credit Guarantee Corporation of India, Sustainalytics, Collection, Growth, SGD, Apeiron, AA, S&P Global Ratings, Security (finance), Renewable energy, CGIF

Rated AA by S&P Global Ratings, the privately placed bond was well-received by investors and was oversubscribed despite a challenging macro environment.

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Rated AA by S&P Global Ratings, the privately placed bond was well-received by investors and was oversubscribed despite a challenging macro environment.
The green bond was issued at par and bears a coupon rate of 4.487% with HSBC as the sole lead manager.
This will allow Apeiron to expand our operations and maintain our position as a leader in the bioenergy sector.
Sean Henderson, Co-Head of Debt Capital Markets, Asia-Pacific at HSBC said, "We are pleased to have supported this landmark transaction for Apeiron, the first ever SGD bond issuance from the bioenergy industry in Asia.

New Web3 Roguelite Apeiron Arrives on Epic Games Store

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Wednesday, June 28, 2023

Cosmos, Black and White, Avatar, NFT, Epic Games Store, USDC, Interest, MOBA, Mad God, White, Apeiron, Female, Video game, Spore

SINGAPORE , June 27, 2023 (GLOBE NEWSWIRE) -- Apeiron, a new type of roguelite x god game developed using cutting edge Web3 technology, has just launched its season 2 battle demo on the Epic Games Store.

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SINGAPORE , June 27, 2023 (GLOBE NEWSWIRE) -- Apeiron, a new type of roguelite x god game developed using cutting edge Web3 technology, has just launched its season 2 battle demo on the Epic Games Store.
Compared with classic god games such as Black and White, Populous, and Spore, Apeiron’s gameplay is an addictive mashup of genres like MOBA, card game, and autobattler.
The new roguelite’s action-adventure gameplay allows players to become a god and take control of a divine elemental construct known as an Avatar.
Following its launch on the Epic Games Store, Foonie Magus, Apeiron’s developers, will be committed to bringing the game to other platforms, so that more players may pick up the game on their preferred device.

Apollo-Managed Funds Announce Upsize and Extension of Delos Platform, an Investment Partnership with Apeiron Management

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Wednesday, March 29, 2023

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MILAN, Italy and NEW YORK, March 29, 2023 (GLOBE NEWSWIRE) -- Apollo (NYSE: APO) today announced the upsize and extension of the Apollo Delos platform, an investment partnership between funds managed by its affiliates (the “Apollo Funds”) and Apeiron Management SpA (“Apeiron”) that focuses on special situations and corporate credit investment opportunities in Italy.

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MILAN, Italy and NEW YORK, March 29, 2023 (GLOBE NEWSWIRE) -- Apollo (NYSE: APO) today announced the upsize and extension of the Apollo Delos platform, an investment partnership between funds managed by its affiliates (the “Apollo Funds”) and Apeiron Management SpA (“Apeiron”) that focuses on special situations and corporate credit investment opportunities in Italy.
Apeiron will continue to work with Apollo, providing support in the origination, due diligence, structuring, execution and management of transactions under the Apollo Delos platform.
The platform will be upsized by EUR 150 million with immediate effect and Apollo Funds can also invest in larger Apeiron transactions on an opportunistic basis.
Alessandro Fracanzani, Founding Partner and CEO of Apeiron Management said, “Apeiron is delighted by this upsized and extended commitment.

Three Sixty Solar Towers to be Used to Develop Broadband Network

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Thursday, March 23, 2023

Osoyoos, Internet, Telecommunications, Wireless, Three Sixty, Archery, OTC, Apeiron, NEO, Renewable energy, Mobile phone

Three Sixty Solar’s CEO, Brian Roth states, “I am pleased to see our Distribution Agreement with Archer bearing fruit.

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Three Sixty Solar’s CEO, Brian Roth states, “I am pleased to see our Distribution Agreement with Archer bearing fruit.
Hook’d can combine multiple signal sources or a single fiber connection to build a network utilizing Three Sixty Solar Towers as a telecommunications platform.
Hook’d has indicated their intention to deploy their “Last Mile” technology on solar towers to create a Broadband Wireless Internet network in the Okanagan region of British Columbia.
The network is expected to be expanded with multiple new solar towers to be deployed in the areas around Kelowna, Vernon, and Osoyoos over the coming months.

Significant Investor in Sensei Biotherapeutics, Inc. Urges Board to Seek Shareholder Mandate

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Monday, November 21, 2022

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Unfortunately, the Board has made it clear that it has no intention to act.

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Unfortunately, the Board has made it clear that it has no intention to act.
In the meantime, not a single stockholder has come forward in defense of the Board and the management team.
In addition, the Board and management are shielded from any accountability to stockholders due to the Companys very shareholder-unfriendly corporate governance profile, including its staggered Board.
We encourage all other Sensei stockholders to express their views and let their voices be heard by reaching out directly to the Board.

Temasek's Vertex Leads $4M Investment in CARV to Build Gaming Credential and Data Infrastructure

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Tuesday, November 22, 2022

Many investors bring infrastructure and gaming ecosystem synergies to CARV, especially across the US, Europe, LATAM, and Southeast Asia markets.

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Many investors bring infrastructure and gaming ecosystem synergies to CARV, especially across the US, Europe, LATAM, and Southeast Asia markets.
"By creating the infrastructure to piece these breadcrumbs together, we are unlocking tremendous opportunities in how gamers interact in the gaming universe."
With the new funding, CARV will onboard additional talents and continue to build the interoperable credential infrastructure alongside ecosystem partners.
CARV is building an interoperable credential infrastructure focused on gaming, enabling gamers with an all-in-one achievement display, semantic friend and game recommendations, and access to credential-gated gaming premiums.

KonaTel Reports Third Quarter 2022 Results

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Monday, November 14, 2022

DALLAS, Nov. 14, 2022 /PRNewswire/ -- KonaTel, Inc. (OTCQB: KTEL) (www.konatel.com), a voice/data communications holding company, today announced financial results for the third quarter and nine-month period ended September 30, 2022.

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DALLAS, Nov. 14, 2022 /PRNewswire/ -- KonaTel, Inc. (OTCQB: KTEL) ( www.konatel.com ), a voice/data communications holding company, today announced financial results for the third quarter and nine-month period ended September 30, 2022.
Revenues of $5.9 million, up 62.8% compared to the third quarter last year and up 14.8% compared to the second quarter of this year.
D. Sean McEwen, Chairman and CEO of KonaTel stated, "Third quarter revenue grew 63% year-over-year and 15% sequentially to nearly $6.0 million.
Mobile customer acquisition costs for the third quarter 2022 were $2.9 million compared to $283,000 for the third quarter of 2021.

Apeiron Bioenergy secures equity investment from Proterra Investment Partners Asia to solidify upstream capabilities

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Thursday, October 6, 2022

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- Apeiron will leverage Proterra's strength in food-agriculture, natural resource sectors and renewable feedstock

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- Apeiron will leverage Proterra's strength in food-agriculture, natural resource sectors and renewable feedstock
Singapore, Oct 6, 2022 - (ACN Newswire) - Apeiron Bioenergy has entered into an equity investment agreement with Proterra Investment Partners Asia.
"Considering the extremely tough macro environment now, it is a testament for Apeiron Bioenergy to weather such conditions and successfully fundraise," said Chris Chen, Co-founder at Apeiron Bioenergy.
"Together with Apeiron, we can help organize and upcycle food waste streams across Asia and in the process support advanced biofuel development globally," said Tai Lin, Managing Partner of Proterra Investment Partners Asia.
In addition, further avenues for strategic collaboration will be made possible with Proterra Investment Partners Asia, whose food and agricultural investment management expertise and upstream connections will fast-track growth.

Basilea announces sale of preclinical oncology program to Nodus Oncology

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Thursday, September 8, 2022

The structure of the transaction ensures that Basilea continues to participate in the long-term value creation potential of this exciting program.

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The structure of the transaction ensures that Basilea continues to participate in the long-term value creation potential of this exciting program.
We also continue our ongoing partnering discussions for BAL0891 and our second pre-clinical program, for which we aim to complete transactions before the end of 2022.
Ian Waddell, Chief Executive Officer of Nodus Oncology, said: Nodus acquisition of Basileas PARG inhibitor program demonstrates our ongoing commitment to developing, and bringing to patients, drugs addressing next generation DDR targets.
Founded by Cumulus Oncology, which contributes capital and oncology discovery and development expertise to the creation of new biotech companies, Nodus has received seed investment from both Cumulus Oncology and additional investors.