Molecular evolution

For tomato genes, one plus one doesn't always make two

Retrieved on: 
Monday, April 12, 2021
Branches of biology, Biology, Evolutionary biology, Life sciences, Molecular evolution, Mutation, Epistasis, Genetic, DNA, Point mutation, Evolvability

That is because every individual has a unique set of genetic variations mutationsthat affect how genes act and function.

Key Points: 
  • That is because every individual has a unique set of genetic variations mutationsthat affect how genes act and function.
  • Added together, millions of small genetic variations make it hard to predict how a particular mutation will impact any individual.
  • They generated over 60 tomato mutants by removing little pieces of DNA in the promoter regions, areas near the genes that control their expression.
  • "\nThis range of interactions for any two mutations models the consequences of a single mutation occurring in different genetic backgrounds.

Cognition Therapeutics Elucidates Genetic Mutation that Protects Against Alzheimer’s Disease

Retrieved on: 
Monday, October 19, 2020
Branches of biology, Biology, Articles, Evolutionary biology, Molecular evolution, Mutation, Alzheimer's disease, Disease

It has been well documented that individuals with the A673T mutation (Icelandic mutation) in the protein A are four times less likely to develop Alzheimers disease than are noncarriers, making this the strongest protective mutation discovered to date for this disease.

Key Points: 
  • It has been well documented that individuals with the A673T mutation (Icelandic mutation) in the protein A are four times less likely to develop Alzheimers disease than are noncarriers, making this the strongest protective mutation discovered to date for this disease.
  • Cognition scientists conducted a series of studies to clarify the mechanism by which this genetic mutation confers protection against Alzheimers disease.
  • This suggests that the reduction in oligomer binding is the main reason Icelandic mutation carriers are four times less likely to develop Alzheimers disease.
  • This research will have a profound impact on Alzheimers disease-modifying therapeutic research, as it lays out a clear mechanism for effective Alzheimers therapeutics, concluded Lisa Ricciardi , president and CEO of Cognition Therapeutics.

Bionano Genomics' Saphyr System Shown to be Indispensable for the Analysis of Certain Genetic Disease Causing Variants

Retrieved on: 
Thursday, October 15, 2020
Branches of biology, Biology, Mutation, Molecular evolution, Chromosomes, Gene duplication, Structural variation, Optical mapping, Segmental duplication on the human Y chromosome

Only Bionanos optical mapping technology can image single molecules that are so long that they span the segmental duplications.

Key Points: 
  • Only Bionanos optical mapping technology can image single molecules that are so long that they span the segmental duplications.
  • These repetitive sequences can interact with each other when sperm or eggs are created and their rearrangement can cause severe genetic disease.
  • Several novel SVs were detected for each locus, and the exact disease causing rearrangement was determined with much higher accuracy than was formerly possible without Saphyr.
  • An increasing number of studies have relied on Bionanos Saphyr system to characterize disease-causing structural variants that could not be correctly analyzed with other molecular techniques.

Industrial-Scale Phenotyping of Cell-Cycle Control in Yeast

Retrieved on: 
Tuesday, May 26, 2020
Branches of biology, Biology, Evolutionary biology, Molecular evolution, Mutation, Genetics, Genomics, Molecular genetics, Synthetic genetic array, Synthetic lethality

By focusing their attention on the inner workings of yeast, scientists have made remarkable progress in learning how cells control cell division and growth.

Key Points: 
  • By focusing their attention on the inner workings of yeast, scientists have made remarkable progress in learning how cells control cell division and growth.
  • Synthetic lethal mutations arise when viable yeast cells carrying deletions of two different genes are crossed to produce double-mutant cells that are unable to grow and survive.
  • Genetic interactions derived from high-throughput phenotyping of 6589 yeast cell cycle mutants.
  • The GenoFAB Automation Platform accelerates biomedical research projects by connecting laboratory operations with data services and supply chain transactions.

Registration Now Open for Deep Mutational Scanning Symposium & Workshop Hosted by Brotman Baty Institute and Center for the Multiplex Assessment of Phenotype, Jan. 13 - 14

Retrieved on: 
Thursday, December 12, 2019
Evolutionary biology, Molecular evolution, Mutation

SEATTLE, Dec. 12, 2019 /PRNewswire/ -- Brotman Baty Institute for Precision Medicine (BBI) and Center for the Multiplex Assessment of Phenotype will co-sponsor a two-day Deep Mutational Scanning Symposium & Workshop in Seattle on Jan. 13 and 14, 2020.

Key Points: 
  • SEATTLE, Dec. 12, 2019 /PRNewswire/ -- Brotman Baty Institute for Precision Medicine (BBI) and Center for the Multiplex Assessment of Phenotype will co-sponsor a two-day Deep Mutational Scanning Symposium & Workshop in Seattle on Jan. 13 and 14, 2020.
  • The event will consist of a Deep Mutational Scanning Symposium on Monday, Jan. 13, followed by a workshop for participants on Tuesday, Jan. 14.
  • Deep mutational scanning is a cutting-edge method to study the effects of mutations on the function of proteins.
  • Deep mutational scanning has the exciting potential to unlock new treatment avenues for diseases as varied as influenza and Amyotrophic Lateral Sclerosis (ALS).